cabozantinib

ret proto-oncogene ; Homo sapiens







81 Article(s)
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1 33471819 Cabozantinib can block growth of neuroendocrine prostate cancer patient-derived xenografts by disrupting tumor vasculature. 2021 4
2 33525725 Molecular Modelling Studies on Pyrazole Derivatives for the Design of Potent Rearranged during Transfection Kinase Inhibitors. 2021 Jan 28 1
3 34058344 Discovery and optimization of selective RET inhibitors via scaffold hopping. 2021 Sep 1 2
4 34117374 Cabozantinib promotes erythroid differentiation in K562 erythroleukemia cells through global changes in gene expression and JNK activation. 2021 Jun 11 1
5 34445927 Antitumor effects of the multi-target tyrosine kinase inhibitor cabozantinib: a comprehensive review of the preclinical evidence. 2021 Sep 2
6 34497761 Targeted Therapy for RET Fusion Lung Cancer: Breakthrough and Unresolved Issue. 2021 1
7 34733735 Case report: identification of ERC1-RET fusion in a patient with pancreatic ductal adenocarcinoma. 2021 Sep 1
8 34826838 [Medullary thyroid carcinoma: current clinical progress]. 2021 Nov 1
9 34830178 Cabozantinib Is Effective in Melanoma Brain Metastasis Cell Lines and Affects Key Signaling Pathways. 2021 Nov 14 3
10 34834190 Discovery of a Potent Candidate for RET-Specific Non-Small-Cell Lung Cancer-A Combined In Silico and In Vitro Strategy. 2021 Oct 24 1
11 31900481 Objective Response and Prolonged Disease Control of Advanced Adrenocortical Carcinoma with Cabozantinib. 2020 May 1 2
12 32083304 Characteristics and outcomes of RET-rearranged Korean non-small cell lung cancer patients in real-world practice. 2020 May 5 1
13 32083997 State-of-the-Art Strategies for Targeting RET-Dependent Cancers. 2020 Apr 10 2
14 32100934 Efficacy of Cabozantinib and Nivolumab in Treating Hepatocellular Carcinoma with RET Amplification, High Tumor Mutational Burden, and PD-L1 Expression. 2020 Jun 3
15 32463152 A Phase II Trial of Cabozantinib in Hormone Receptor-Positive Breast Cancer with Bone Metastases. 2020 Aug 1
16 32532875 Case report for an adolescent with germline RET mutation and alveolar rhabdomyosarcoma. 2020 Jun 1
17 32645282 Cabozantinib in patients with platinum-refractory metastatic urothelial carcinoma: an open-label, single-centre, phase 2 trial. 2020 Aug 1
18 32671719 Cabozantinib for the Treatment of Advanced Hepatocellular Carcinoma: Current Data and Future Perspectives. 2020 Aug 2
19 32718536 Identification of a Novel KIF5B-RET, ABHD17C-RET Double-Fusion Variant in Lung Adenocarcinoma and Response to Cabozantinib. 2020 Aug 2
20 32835580 Enhanced antitumor effect of alectinib in combination with cyclin-dependent kinase 4/6 inhibitor against RET-fusion-positive non-small cell lung cancer cells. 2020 Sep 1 2
21 32846061 Efficacy of Selpercatinib in RET-Altered Thyroid Cancers. 2020 Aug 27 1
22 33318047 RET inhibition in novel patient-derived models of RET-fusion positive lung adenocarcinoma reveals a role for MYC upregulation. 2020 Dec 14 3
23 30131091 Clinical Characteristics and Molecular Patterns of RET-Rearranged Lung Cancer in Chinese Patients. 2019 May 7 1
24 30528315 Results of a Phase II Placebo-controlled Randomized Discontinuation Trial of Cabozantinib in Patients with Non-small-cell Lung Carcinoma. 2019 Mar 1
25 30587441 A randomized phase II study of cabozantinib versus weekly paclitaxel in the treatment of persistent or recurrent epithelial ovarian, fallopian tube or primary peritoneal cancer: An NRG Oncology/Gynecologic Oncology Group study. 2019 Mar 1
26 30653139 RET fusion in advanced non-small-cell lung cancer and response to cabozantinib: A case report. 2019 Jan 2
27 30718102 Phase 1 Study of Cabozantinib in Japanese Patients With Expansion Cohorts in Non-Small-Cell Lung Cancer. 2019 May 1
28 30929576 RET Kinase-Regulated MicroRNA-153-3p Improves Therapeutic Efficacy in Medullary Thyroid Carcinoma. 2019 Jun 1
29 30935646 Reversible Cabozantinib-Induced Cardiomyopathy. 2019 Apr 1
30 32914006 Use of Cabozantinib in a Patient With EGFR-Mutated Non-Small-Cell Lung Cancer Harboring Acquired CCDC6-RET Fusion. 2019 1
31 29284153 Role of RET protein-tyrosine kinase inhibitors in the treatment RET-driven thyroid and lung cancers. 2018 Feb 1
32 29571998 Identification of a novel KIF13A-RET fusion in lung adenocarcinoma by next-generation sequencing. 2018 Apr 1
33 29662541 Cabozantinib in the treatment of advanced renal cell carcinoma in adults following prior vascular endothelial growth factor targeted therapy: clinical trial evidence and experience. 2018 Mar 1
34 29908090 Drug resistance profiles of mutations in the RET kinase domain. 2018 Sep 1
35 30069760 Cabozantinib: Multi-kinase Inhibitor of MET, AXL, RET, and VEGFR2. 2018 2
36 30210625 NCOA4-RET fusion in colorectal cancer: Therapeutic challenge using patient-derived tumor cell lines. 2018 1
37 30257958 Landscape of Acquired Resistance to Osimertinib in EGFR-Mutant NSCLC and Clinical Validation of Combined EGFR and RET Inhibition with Osimertinib and BLU-667 for Acquired RET Fusion. 2018 Dec 2
38 30446652 RET rearrangements are actionable alterations in breast cancer. 2018 Nov 16 1
39 27842445 Cabozantinib in genitourinary malignancies. 2017 Apr 1
40 27922668 Dual inhibition using cabozantinib overcomes HGF/MET signaling mediated resistance to pan-VEGFR inhibition in orthotopic and metastatic neuroblastoma tumors. 2017 Jan 1
41 28477875 [Cabozantinib: Mechanism of action, efficacy and indications]. 2017 May 2
42 28650002 Cabozantinib use in renal cell carcinoma. 2017 May 1
43 28703624 Cabozantinib in the treatment of hepatocellular carcinoma. 2017 Sep 1
44 29045520 Overall survival analysis of EXAM, a phase III trial of cabozantinib in patients with radiographically progressive medullary thyroid carcinoma. 2017 Nov 1 4
45 29059635 Phase II randomised discontinuation trial of cabozantinib in patients with advanced solid tumours. 2017 Nov 1
46 29088743 In vitro and in vivo anti-tumor activity of alectinib in tumor cells with NCOA4-RET. 2017 Sep 26 2
47 26536165 Cabozantinib for the treatment of progressive metastatic medullary thyroid cancer. 2016 3
48 26652860 A Pyrazolo[3,4-d]pyrimidin-4-amine Derivative Containing an Isoxazole Moiety Is a Selective and Potent Inhibitor of RET Gatekeeper Mutants. 2016 Jan 14 2
49 26973202 ALK, ROS1 and RET rearrangements in lung squamous cell carcinoma are very rare. 2016 Apr 2
50 27429741 Identification of selective inhibitors of RET and comparison with current clinical candidates through development and validation of a robust screening cascade. 2016 1