| 1 |
34995500 | DOT1L inhibition enhances pluripotency beyond acquisition of epithelial identity and without immediate suppression of the somatic transcriptome. | 2022 Feb 8 |
1 |
| 2 |
35172132 | DOT1L activity in leukemia cells requires interaction with ubiquitylated H2B that promotes productive nucleosome binding. | 2022 Feb 15 |
2 |
| 3 |
35331314 | Targeting the histone H3 lysine 79 methyltransferase DOT1L in MLL-rearranged leukemias. | 2022 Mar 24 |
2 |
| 4 |
35350907 | Histone methyltransferase Dot1L inhibits pancreatic cancer cell apoptosis by promoting NUPR1 expression. | 2022 Mar |
1 |
| 5 |
33315499 | Targeted disruption of the histone lysine 79 methyltransferase Dot1L in nephron progenitors causes congenital renal dysplasia. | 2021 Nov |
1 |
| 6 |
33636429 | Synthesis and biological activity of selenopsammaplin A and its analogues as antitumor agents with DOT1L inhibitory activity. | 2021 Apr 1 |
2 |
| 7 |
33795413 | DOT1L Regulates Thermogenic Adipocyte Differentiation and Function via Modulating H3K79 Methylation. | 2021 Jun |
1 |
| 8 |
34215314 | AF10 (MLLT10) prevents somatic cell reprogramming through regulation of DOT1L-mediated H3K79 methylation. | 2021 Jul 2 |
1 |
| 9 |
34500733 | Synthesis and Biological Activity of a Cytostatic Inhibitor of MLLr Leukemia Targeting the DOT1L Protein. | 2021 Aug 31 |
1 |
| 10 |
32215184 | DOT1L inhibition is lethal for multiple myeloma due to perturbation of the endoplasmic reticulum stress pathway. | 2020 Mar 17 |
1 |
| 11 |
32244385 | Antiproliferative and Antimigration Activities of Fluoro-Neplanocin A via Inhibition of Histone H3 Methylation in Triple-Negative Breast Cancer. | 2020 Mar 31 |
1 |
| 12 |
32450905 | Therapeutic strategies against hDOT1L as a potential drug target in MLL-rearranged leukemias. | 2020 May 25 |
1 |
| 13 |
32471461 | Differentiation and localization of interneurons in the developing spinal cord depends on DOT1L expression. | 2020 May 29 |
1 |
| 14 |
32552847 | The lncRNA LAMP5-AS1 drives leukemia cell stemness by directly modulating DOT1L methyltransferase activity in MLL leukemia. | 2020 Jun 17 |
1 |
| 15 |
32634241 | Specific patterns of H3K79 methylation influence genetic interaction of oncogenes in AML. | 2020 Jul 14 |
1 |
| 16 |
32814769 | Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer. | 2020 Aug 19 |
1 |
| 17 |
30359161 | Discovery of a Selective Inhibitor for the YEATS Domains of ENL/AF9. | 2019 Feb |
1 |
| 18 |
30616689 | The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness. | 2019 Jan 7 |
2 |
| 19 |
30759380 | Structural Basis for Recognition of Ubiquitylated Nucleosome by Dot1L Methyltransferase. | 2019 Feb 12 |
1 |
| 20 |
30899413 | Depletion of H3K79 methyltransferase Dot1L promotes cell invasion and cancer stem-like cell property in ovarian cancer. | 2019 |
2 |
| 21 |
30951287 | Computer-Aided Discovery of Massonianoside B as a Novel Selective DOT1L Inhibitor. | 2019 May 17 |
2 |
| 22 |
30981630 | Structural Basis of Dot1L Stimulation by Histone H2B Lysine 120Â Ubiquitination. | 2019 Jun 6 |
2 |
| 23 |
31173720 | Methylation of Histone H3K79 by Dot1L Requires Multiple Contacts with the Ubiquitinated Nucleosome. | 2019 Jun 6 |
2 |
| 24 |
31300558 | DOT1L complex suppresses transcription from enhancer elements and ectopic RNAi in Caenorhabditis elegans. | 2019 Oct |
1 |
| 25 |
31524790 | A novel germline variant in the DOT1L gene co-segregating in a Dutch family with a history of melanoma. | 2019 Dec |
1 |
| 26 |
29339748 | Dot1 regulates nucleosome dynamics by its inherent histone chaperone activity in yeast. | 2018 Jan 16 |
1 |
| 27 |
29343685 | The protective role of DOT1L in UV-induced melanomagenesis. | 2018 Jan 17 |
1 |
| 28 |
29495487 | DOT1L and H3K79 Methylation in Transcription and Genomic Stability. | 2018 Feb 27 |
1 |
| 29 |
28209620 | The Histone Methyltransferase DOT1L Promotes Neuroblastoma by Regulating Gene Transcription. | 2017 May 1 |
1 |
| 30 |
28229434 | Preclinical Pharmacokinetics and Pharmacodynamics of Pinometostat (EPZ-5676), a First-in-Class, Small Molecule S-Adenosyl Methionine Competitive Inhibitor of DOT1L. | 2017 Dec |
1 |
| 31 |
26728620 | The upstreams and downstreams of H3K79 methylation by DOT1L. | 2016 Sep |
1 |
| 32 |
26783998 | DOT1L histone methyltransferase regulates the expression of BCAT1 and is involved in sphere formation and cell migration of breast cancer cell lines. | 2016 Apr |
1 |
| 33 |
26830124 | Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation. | 2016 Feb 2 |
1 |
| 34 |
26970896 | Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia. | 2016 Mar 12 |
1 |
| 35 |
27115831 | In Situ Proteome Profiling and Bioimaging Applications of Small-Molecule Affinity-Based Probes Derived From DOT1L Inhibitors. | 2016 Jun 1 |
1 |
| 36 |
27234562 | The many faces of histone H3K79 methylation. | 2016 Apr-Jun |
1 |
| 37 |
27713173 | Dot1l expression predicts adverse postoperative prognosis of patients with clear-cell renal cell carcinoma. | 2016 Dec 20 |
3 |
| 38 |
25361163 | Regulation of Wnt signaling target gene expression by the histone methyltransferase DOT1L. | 2015 Jan 16 |
1 |
| 39 |
25987043 | Novel DOT1L ReceptorNatural Inhibitors Involved in Mixed Lineage Leukemia: a Virtual Screening, Molecular Docking and Dynamics Simulation Study. | 2015 |
1 |
| 40 |
26199140 | DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression. | 2015 Jul 22 |
1 |
| 41 |
26385168 | Exploring drug delivery for the DOT1L inhibitor pinometostat (EPZ-5676): Subcutaneous administration as an alternative to continuous IV infusion, in the pursuit of an epigenetic target. | 2015 Dec 28 |
1 |
| 42 |
26609488 | The histone methyltransferase DOT1L: regulatory functions and a cancer therapy target. | 2015 |
1 |
| 43 |
24526115 | The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle. | 2014 |
2 |
| 44 |
24816405 | IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L. | 2014 May 15 |
1 |
| 45 |
24858818 | DOT1L inhibition sensitizes MLL-rearranged AML to chemotherapy. | 2014 |
1 |
| 46 |
25387577 | Structure-guided mutational analysis reveals the functional requirements for product specificity of DOT1 enzymes. | 2014 Nov 12 |
1 |
| 47 |
23382701 | Dot1-dependent histone H3K79 methylation promotes activation of the Mek1 meiotic checkpoint effector kinase by regulating the Hop1 adaptor. | 2013 |
1 |
| 48 |
23412334 | Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia. | 2013 Mar 5 |
1 |
| 49 |
23891621 | CBX8, a component of the Polycomb PRC1 complex, modulates DOT1L-mediated gene expression through AF9/MLLT3. | 2013 Sep 17 |
1 |
| 50 |
22190683 | Deficiency of H3K79 histone methyltransferase Dot1-like protein (DOT1L) inhibits cell proliferation. | 2012 Feb 17 |
2 |