Etoposide

DNA topoisomerase II beta ; Homo sapiens







27 Article(s)
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1 33941661 A Role for VCP/p97 in the Processing of Drug-Stabilized TOP2-DNA Covalent Complexes. 2021 Jul 1
2 31429692 Molecular Docking Based Analysis to Elucidate the DNA Topoisomerase IIβ as the Potential Target for the Ganoderic Acid; A Natural Therapeutic Agent in Cancer Therapy. 2020 1
3 31090963 NEK5 interacts with topoisomerase IIβ and is involved in the DNA damage response induced by etoposide. 2019 Oct 2
4 31399497 Intercalating TOP2 Poisons Attenuate Topoisomerase Action at Higher Concentrations. 2019 Oct 1
5 31449404 Smoothed Potential MD Simulations for Dissociation Kinetics of Etoposide To Unravel Isoform Specificity in Targeting Human Topoisomerase II. 2019 Sep 23 1
6 29447373 Coupling the core of the anticancer drug etoposide to an oligonucleotide induces topoisomerase II-mediated cleavage at specific DNA sequences. 2018 Mar 16 1
7 29765039 STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion. 2018 May 15 1
8 30297860 Increasing the distance between two monomers of topoisomerase IIβ under the action of antitumor agent 4β-sulfur-(benzimidazole) 4'-demethylepipodophyllotoxin. 2018 Oct 8 1
9 27974636 Myeloperoxidase Enhances Etoposide and Mitoxantrone-Mediated DNA Damage: A Target for Myeloprotection in Cancer Chemotherapy. 2017 Jan 2
10 28110185 Computational analysis of Amsacrine resistance in human topoisomerase II alpha mutants (R487K and E571K) using homology modeling, docking and all-atom molecular dynamics simulation in explicit solvent. 2017 Mar 1
11 27484510 Synthesis and biological evaluation of C1-O-substituted-3-(3-butylamino-2-hydroxy-propoxy)-xanthen-9-one as topoisomerase IIα catalytic inhibitors. 2016 Nov 10 1
12 25945730 Differential Targeting of Human Topoisomerase II Isoforms with Small Molecules. 2015 Jun 11 1
13 24327541 The role of topoisomerase II beta on breakage and proximity of RUNX1 to partner alleles RUNX1T1 and EVI1. 2014 Feb 7
14 24766193 Etoposide quinone is a covalent poison of human topoisomerase IIβ. 2014 May 20 1
15 24038465 On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs. 2013 Dec 1
16 22528119 The polyphenolic ellagitannin vescalagin acts as a preferential catalytic inhibitor of the α isoform of human DNA topoisomerase II. 2012 Jul 1
17 22615413 Model for MLL translocations in therapy-related leukemia involving topoisomerase IIβ-mediated DNA strand breaks and gene proximity. 2012 Jun 5 1
18 22841979 The structure of DNA-bound human topoisomerase II alpha: conformational mechanisms for coordinating inter-subunit interactions with DNA cleavage. 2012 Dec 7 2
19 21778401 Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide. 2011 Jul 22 1
20 20886683 Chromatin remodelling at the topoisomerase II-beta promoter is associated with enhanced sensitivity to etoposide in human neuroblastoma cell lines. 2010 Oct 2
21 19230382 Inhibition of DNA topoisomerase II with etoposide induces association of DNA topoisomerase II alpha, DNA topoisomerase II beta, and nucleolin with BCR 2 of the ETO gene. 2008 Nov-Dec 1
22 16914690 Topoisomerase IIB and an extracellular nuclease interact to digest sperm DNA in an apoptotic-like manner. 2006 Nov 1
23 15322234 Mutation E522K in human DNA topoisomerase IIbeta confers resistance to methyl N-(4'-(9-acridinylamino)-phenyl)carbamate hydrochloride and methyl N-(4'-(9-acridinylamino)-3-methoxy-phenyl) methane sulfonamide but hypersensitivity to etoposide. 2004 Sep 1
24 9331091 Role of topoisomerase II beta in the resistance of 9-OH-ellipticine-resistant Chinese hamster fibroblasts to topoisomerase II inhibitors. 1997 Oct 1 1
25 9422071 [Expression of DNA topoisomerases (I, II alpha, II beta) mRNA in etoposide- and mAMSA-resistant cell lines]. 1997 Dec 1
26 7805045 Relationship of DNA topoisomerase II alpha and beta expression to cytotoxicity of antineoplastic agents in human acute lymphoblastic leukemia cell lines. 1995 Jan 1 1
27 8519659 Relationship between expression of topoisomerase II isoforms and intrinsic sensitivity to topoisomerase II inhibitors in breast cancer cell lines. 1995 Dec 1