dehydroxymethylepoxyquinomicin

nuclear factor kappa B subunit 1 ; Homo sapiens







65 Article(s)
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1 34848454 Intravenous Administration of Dehydroxymethylepoxyquinomicin With Polymer Enhances the Inhibition of Pancreatic Carcinoma Growth in Mice. 2021 Dec 2
2 32377746 Anti‑inflammatory effects of the NF‑κB inhibitor dehydroxymethylepoxyquinomicin on ARPE‑19 cells. 2020 Jul 3
3 30724631 Dehydroxymethylepoxyquinomicin suppresses atopic dermatitis-like lesions in a stratum corneum-removed murine model through NF-κB inhibition. 2019 Feb 5
4 31446998 Targeting NF-κB-mediated inflammatory pathways in cisplatin-resistant NSCLC. 2019 Sep 2
5 31653220 Role of nuclear factor-kappa B in feline injection site sarcoma. 2019 Oct 25 1
6 29141555 Antineoplastic Effects of NF-κB Inhibition by DHMEQ (Dehydroxymethylepoxyquinomicin) Alone and in Co-treatment with Radio-and Chemotherapy in Medulloblastoma Cell Lines. 2018 5
7 28003138 Rational design, synthesis and in vitro evaluation of novel exo-methylene butyrolactone salicyloylamide as NF-κB inhibitor. 2017 Feb 1 2
8 28107418 NF-kappaB Is Involved in the Regulation of EMT Genes in Breast Cancer Cells. 2017 2
9 26802647 Inhibition of NF-κB Activity Enhances Sensitivity to Anticancer Drugs in Cholangiocarcinoma Cells. 2016 Jan 21 3
10 27831555 Activation and cleavage of SASH1 by caspase-3 mediates an apoptotic response. 2016 Nov 10 3
11 28078047 Inhibition of NF-kappaB with Dehydroxymethylepoxyquinomicin modifies the function of human peritoneal mesothelial cells. 2016 2
12 25519802 Dehydroxymethylepoxyquinomicin, a novel nuclear factor-κB inhibitor, reduces chemokines and adhesion molecule expression induced by IL-1β in human corneal fibroblasts. 2015 Apr 6
13 25706397 Inhibition of canonical NF-κB nuclear localization by (-)-DHMEQ via impairment of DNA binding. 2015 4
14 25926105 Down-regulation of NF kappa B activation is an effective therapeutic modality in acquired platinum-resistant bladder cancer. 2015 Apr 29 2
15 26502701 INHIBITOR OF THE TRANSCRIPTION FACTOR NF-κB, DHMEQ, ENHANCES THE EFFECT OF PACLITAXEL ON CELLS OF ANAPLASTIC THYROID CARCINOMA IN VITRO AND IN VIVO. 2015 May-Jun 2
16 24724610 DSE-FRET: A new anticancer drug screening assay for DNA binding proteins. 2014 Jul 2
17 24867687 Immunosuppression through constitutively activated NF-κB signalling in human ovarian cancer and its reversal by an NF-κB inhibitor. 2014 Jun 10 2
18 25025901 Strategic targeting of the PI3K-NFκB axis in cisplatin-resistant NSCLC. 2014 Oct 1
19 25170898 Aberrant expression of NF-κB in liver fluke associated cholangiocarcinoma: implications for targeted therapy. 2014 5
20 23504230 Screening of new bioactive metabolites for diabetes therapy. 2013 Apr 1
21 23533755 Inhibition of NF- κ B by Dehydroxymethylepoxyquinomicin Suppresses Invasion and Synergistically Potentiates Temozolomide and γ -Radiation Cytotoxicity in Glioblastoma Cells. 2013 3
22 23633516 p53 dysfunction precedes the activation of nuclear factor-κB during disease progression in mice expressing Tax, a human T-cell leukemia virus type 1 oncoprotein. 2013 Sep 3
23 23690471 Pleiotropic potential of dehydroxymethylepoxyquinomicin for NF-κB suppression via reactive oxygen species and unfolded protein response. 2013 Jun 15 12
24 24762223 Combined inhibition of NF-κB and Bcl-2 triggers synergistic reduction of viability and induces apoptosis in melanoma cells. 2013 8
25 22343223 The novel NF-κB inhibitor DHMEQ synergizes with celecoxib to exert antitumor effects on human liver cancer cells by a ROS-dependent mechanism. 2012 Sep 1 4
26 22447108 Involvement of NF-κB-mediated expression of galectin-3-binding protein in TNF-α-induced breast cancer cell adhesion. 2012 Jun 2
27 22975513 Interferon gamma induces steroid sulfatase expression in human keratinocytes. 2012 2
28 22976334 A chemo-enzymatic expeditious route to racemic dihexanoyl (2R*,3R*,4R*)-dehydroxymethylepoxyquinomycin (DHMEQ), the precursor for lipase-catalyzed synthesis of the potent nuclear factor-κB inhibitor, (2S,3S,4S)-DHMEQ. 2012 1
29 21288284 Inhibition of nuclear factor-kappaB suppresses peritoneal dissemination of gastric cancer by blocking cancer cell adhesion. 2011 May 1
30 21459660 Anti-tumor activity of dehydroxymethylepoxyquinomicin against human oral squamous cell carcinoma cell lines in vitro and in vivo. 2011 May 2
31 21723080 Possible role of peritoneal NF-κB in peripheral inflammation and cancer: lessons from the inhibitor DHMEQ. 2011 Jul 3
32 21963506 Coffee induces breast cancer resistance protein expression in Caco-2 cells. 2011 1
33 22057485 Role of NF-κB/Snail/RKIP loop in the response of tumor cells to photodynamic therapy. 2011 Sep 1
34 19560263 A small molecule inhibitor of NF-kappaB, dehydroxymethylepoxyquinomicin (DHMEQ), suppresses growth and invasion of nasopharyngeal carcinoma (NPC) cells. 2010 Jan 1 4
35 19997106 Gene set enrichment analysis provides insight into novel signalling pathways in breast cancer stem cells. 2010 Jan 5 2
36 20156648 Potent cytotoxic effect of a novel nuclear factor-kappaB inhibitor dehydroxymethylepoxyquinomicin on human bladder cancer cells producing various cytokines. 2010 Apr 7
37 20638688 Donor pretreatment with DHMEQ improves islet transplantation. 2010 Sep 3
38 20801656 A new NF-κB inhibitor based on the amino-epoxyquinol core of DHMEQ. 2010 Oct 1 2
39 21059341 Involvement of autocrine CXCL12/CXCR4 system in the regulation of ovarian carcinoma cell invasion. 2010 Dec 3 2
40 19275643 Chemosensitization and immunosensitization of resistant cancer cells to apoptosis and inhibition of metastasis by the specific NF-kappaB inhibitor DHMEQ. 2009 7
41 19843864 Pivotal roles of snail inhibition and RKIP induction by the proteasome inhibitor NPI-0052 in tumor cell chemoimmunosensitization. 2009 Nov 1 2
42 18217958 DHMEQ, a novel nuclear factor-kappaB inhibitor, induces selective depletion of alloreactive or phytohaemagglutinin-stimulated peripheral blood mononuclear cells, decreases production of T helper type 1 cytokines, and blocks maturation of dendritic cells. 2008 Jun 3
43 18406579 DHMEQ, a novel NF-kappaB inhibitor, suppresses growth and type I collagen accumulation in keloid fibroblasts. 2008 Sep 4
44 18538617 Induction of apoptosis in Epstein-Barr virus-infected B-lymphocytes by the NF-kappaB inhibitor DHMEQ. 2008 Jun 5
45 18760530 Growth suppression and apoptosis induction in synovial sarcoma cell lines by a novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ). 2008 Dec 18 3
46 18782563 Identification of the RelA domain responsible for action of a new NF-kappaB inhibitor DHMEQ. 2008 Nov 14 9
47 17306602 Reversal of resistance to cytotoxic cancer therapies: DHMEQ as a chemo-sensitizing and immuno-sensitizing agent. 2007 Feb-Apr 6
48 17466373 Targeting NF-kappaB and induction of apoptosis by novel NF-kappaB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) in Burkitt lymphoma cells. 2007 Nov 6
49 16002138 In vitro and in vivo antitumor activity of the NF-kappaB inhibitor DHMEQ in the human T-cell leukemia virus type I-infected cell line, HUT-102. 2006 Jan 4
50 16355386 Effects of a novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), on growth, apoptosis, gene expression, and chemosensitivity in head and neck squamous cell carcinoma cell lines. 2006 Feb 5