Sorafenib

ABL proto-oncogene 1, non-receptor tyrosine kinase ; Homo sapiens







7 Article(s)
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1 24691568 In silico identification of novel kinase inhibitors targeting wild-type and T315I mutant ABL1 from FDA-approved drugs. 2014 Jun 2
2 22846973 Comparison of the effects of two kinase inhibitors, sorafenib and dasatinib, on chronic lymphocytic leukemia cells. 2012 1
3 20337484 Analysis of imatinib and sorafenib binding to p38alpha compared with c-Abl and b-Raf provides structural insights for understanding the selectivity of inhibitors targeting the DFG-out form of protein kinases. 2010 May 4 2
4 20350535 BRAF as therapeutic target in melanoma. 2010 Sep 1 1
5 20621496 The design, synthesis, and evaluation of 8 hybrid DFG-out allosteric kinase inhibitors: a structural analysis of the binding interactions of Gleevec, Nexavar, and BIRB-796. 2010 Aug 1 1
6 19366808 Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway. 2009 May 1 9
7 17595328 The multikinase inhibitor sorafenib induces apoptosis in highly imatinib mesylate-resistant bcr/abl+ human leukemia cells in association with signal transducer and activator of transcription 5 inhibition and myeloid cell leukemia-1 down-regulation. 2007 Sep 5