2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one

mitogen-activated protein kinase kinase 1 ; Mus musculus







131 Article(s)
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1 35431291 Oncostatin M reduces the synthesis of macrophage-colony stimulating factor stimulated by TGF-β via suppression of p44/p42 MAP kinase and JNK in osteoblasts. 2022 1
2 35504090 Enhancement of vitamin C-induced myogenesis by inhibition of extracellular signal-regulated kinase (ERK) 1/2 pathway. 2022 Jul 5 1
3 32567086 HSP90 inhibitors strengthen extracellular ATP-stimulated synthesis of interleukin-6 in osteoblasts: Amplification of p38 MAP kinase. 2021 Jan 1
4 34029590 The dipeptide prolyl-hydroxyproline promotes cellular homeostasis and lamellipodia-driven motility via active β1-integrin in adult tendon cells. 2021 Jul 1
5 34252520 Paclitaxel anticancer activity is enhanced by the MEK 1/2 inhibitor PD98059 in vitro and by PD98059-loaded nanoparticles in BRAFV600E melanoma-bearing mice. 2021 Sep 5 1
6 28034754 LXR agonists promote the proliferation of neural progenitor cells through MEK-ERK pathway. 2017 Jan 29 1
7 27045084 MEK1/2 inhibitors induce interleukin-5 expression in mouse macrophages and lymphocytes. 2016 May 13 2
8 25472814 Progesterone-induced activation of membrane-bound progesterone receptors in murine macrophage cells. 2015 Feb 2
9 25774517 H-Ras mediates the inhibitory effect of epidermal growth factor on the epithelial Na+ channel. 2015 1
10 25791227 Memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic ERK2 bidirectional modulation. 2015 May 21 1
11 26637332 NF-κB transcriptional activation by TNFα requires phospholipase C, extracellular signal-regulated kinase 2 and poly(ADP-ribose) polymerase-1. 2015 Dec 4 1
12 21945831 Liver fibrosis protects mice from acute hepatocellular injury. 2012 Jan 1
13 22033125 Function of MAPK and downstream transcription factors in monomer-induced apoptosis. 2012 Jan 1
14 22228051 Effects of mitogen-activated protein kinase signaling pathway inhibition on the development of cerulein-induced acute pancreatitis in mice. 2012 May 2
15 22762037 Activation of the ERK 1/2 and STAT3 signaling pathways is required for 661W cell survival following oxidant injury. 2012 1
16 22869729 ERK1/2 activation is a therapeutic target in age-related macular degeneration. 2012 Aug 21 1
17 22875961 Expression of LH receptor in nonpregnant mouse endometrium: LH induction of 3β-HSD and de novo synthesis of progesterone. 2012 Oct 1
18 21533992 MEK inhibition suppresses the development of lung fibrosis in the bleomycin model. 2011 Jul 2
19 21589925 MCP-1 upregulates amylin expression in murine pancreatic β cells through ERK/JNK-AP1 and NF-κB related signaling pathways independent of CCR2. 2011 May 11 1
20 21815197 The neuropeptide VIP regulates the expression of osteoclastogenic factors in osteoblasts. 2011 Dec 1
21 21897334 Valproic acid increases susceptibility to endotoxin shock through enhanced release of high-mobility group box 1. 2011 Nov 1
22 19819333 PD98059, a specific MAP kinase inhibitor, attenuates multiple organ dysfunction syndrome/failure (MODS) induced by zymosan in mice. 2010 Feb 2
23 19879324 p70 S6 kinase limits tumor necrosis factor-alpha-induced interleukin-6 synthesis in osteoblast-like cells. 2010 Feb 5 1
24 20035621 Nitric oxide stimulates interleukin-6 production in skeletal myotubes. 2010 May 1
25 20049896 EGF and its related growth factors mediate sodium transport in mpkCCDc14 cells via ErbB2 (neu/HER-2) receptor. 2010 Apr 1
26 20361273 Hmgb1 promotes wound healing of 3T3 mouse fibroblasts via RAGE-dependent ERK1/2 activation. 2010 May 1
27 20372827 Synergistic effect of vasoactive intestinal peptides on TNF-alpha-induced IL-6 synthesis in osteoblasts: amplification of p44/p42 MAP kinase activation. 2010 May 1
28 20420821 Plumbagin activates ERK1/2 and Akt via superoxide, Src and PI3-kinase in 3T3-L1 cells. 2010 Jul 25 1
29 20829510 Apolipoprotein CIII induces monocyte chemoattractant protein-1 and interleukin 6 expression via Toll-like receptor 2 pathway in mouse adipocytes. 2010 Nov 1
30 20837912 Adropin is a novel regulator of endothelial function. 2010 Sep 14 1
31 20926798 Substance P upregulates cyclooxygenase-2 and prostaglandin E metabolite by activating ERK1/2 and NF-kappaB in a mouse model of burn-induced remote acute lung injury. 2010 Nov 15 1
32 21311674 Magnolol Inhibits LPS-induced NF-κB/Rel Activation by Blocking p38 Kinase in Murine Macrophages. 2010 Dec 1
33 21364650 Histone deacetylase 1 and 2 differentially regulate apoptosis by opposing effects on extracellular signal-regulated kinase 1/2. 2010 May 20 1
34 18835438 BCR-ABL induces opposite phenotypes in murine ES cells according to STAT3 activation levels. 2009 Jan 1
35 19016906 Induction of copper/zinc-superoxide dismutase by CCL5/CCR5 activation causes tumour necrosis factor-alpha and reactive oxygen species production in macrophages. 2009 Sep 1
36 19115422 CD133+ liver cancer stem cells from methionine adenosyl transferase 1A-deficient mice demonstrate resistance to transforming growth factor (TGF)-beta-induced apoptosis. 2009 Apr 2
37 19508391 Tripterine prevents endothelial barrier dysfunction by inhibiting endogenous peroxynitrite formation. 2009 Jul 2
38 19524014 Sam68 and ERKs regulate leptin-induced expression of OB-Rb mRNA in C2C12 myotubes. 2009 Oct 15 1
39 19801662 Breast cancer-derived factors stimulate osteoclastogenesis through the Ca2+/protein kinase C and transforming growth factor-beta/MAPK signaling pathways. 2009 Nov 27 1
40 17962702 Gdnf upregulates c-Fos transcription via the Ras/Erk1/2 pathway to promote mouse spermatogonial stem cell proliferation. 2008 Jan 1
41 18196969 Compensatory activation of ERK1/2 in Atg5-deficient mouse embryo fibroblasts suppresses oxidative stress-induced cell death. 2008 Apr 1
42 18372159 Oncostatin M induction of eotaxin-1 expression requires the convergence of PI3'K and ERK1/2 MAPK signal transduction pathways. 2008 Jun 1
43 18555587 Induction of granulocyte colony-stimulating factor by globular adiponectin via the MEK-ERK pathway. 2008 Sep 24 1
44 16927271 Modeled microgravity stimulates osteoclastogenesis and bone resorption by increasing osteoblast RANKL/OPG ratio. 2007 Feb 1 1
45 17108331 Meiotic induction by heat stress in mouse oocytes: involvement of AMP-activated protein kinase and MAPK family members. 2007 Mar 1
46 17113751 Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1. 2007 Mar 1
47 17160024 Chemotherapy resistance of mouse WAP-SVT/t breast cancer cells is mediated by osteopontin, inhibiting apoptosis downstream of caspase-3. 2007 May 3 1
48 17653823 Protein kinase C delta inhibits the production of proteolytic enzymes in murine mammary cells. 2007 1
49 17980568 Platelet-derived growth factor-BB amplifies PGF2alpha-stimulated VEGF synthesis in osteoblasts: function of phosphatidylinositol 3-kinase. 2007 Oct-Nov 1
50 16374521 ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo. 2006 Jan 1