Lysine

RELA proto-oncogene, NF-kB subunit ; Homo sapiens







56 Article(s)
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1 35136209 The KDM6A-SPARCL1 axis blocks metastasis and regulates the tumour microenvironment of gastrointestinal stromal tumours by inhibiting the nuclear translocation of p65. 2022 Jun 1
2 35265200 HDAC5 modulates PD-L1 expression and cancer immunity via p65 deacetylation in pancreatic cancer. 2022 2
3 34378541 An optimized BRD4 inhibitor effectively eliminates NF-κB-driven triple-negative breast cancer cells. 2021 Sep 1
4 32416562 Impact of novel N-aryl substituted piperamide on NF-kappa B translocation as a potent anti-neuroinflammatory agent. 2020 Jul 2
5 32816380 Fragment-Based Stabilizers of Protein-Protein Interactions through Imine-Based Tethering. 2020 Nov 23 1
6 29435148 Peptide inhibition of the SETD6 methyltransferase catalytic activity. 2018 Jan 12 1
7 29440272 Nitric oxide antagonism to glioblastoma photodynamic therapy and mitigation thereof by BET bromodomain inhibitor JQ1. 2018 Apr 6 2
8 28416608 Hyper-O-GlcNAcylation activates nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) signaling through interplay with phosphorylation and acetylation. 2017 Jun 2 2
9 28943877 β-Catenin Directs Nuclear Factor-κB p65 Output via CREB-Binding Protein/p300 in Human Airway Smooth Muscle. 2017 3
10 26915321 [AMP-activated protein kinase activation regulates adhesion of monocytes to vascular endothelial cells and the underlying mechanism]. 2016 Feb 25 1
11 25400040 p28(GANK) associates with p300 to attenuate the acetylation of RelA. 2015 Dec 2
12 25452565 Dysregulated miR-34a-SIRT1-acetyl p65 axis is a potential mediator of immune activation in the colon during chronic simian immunodeficiency virus infection of rhesus macaques. 2015 Jan 1 2
13 25472959 Adverse epigenetic signatures by histone methyltransferase Set7 contribute to vascular dysfunction in patients with type 2 diabetes mellitus. 2015 Feb 1
14 25736763 Methods to detect NF-κB acetylation and methylation. 2015 1
15 25791343 Epigenetic regulation of polyomavirus JC involves acetylation of specific lysine residues in NF-κB p65. 2015 Dec 2
16 23624912 Inhibitor of growth 4 induces NFκB/p65 ubiquitin-dependent degradation. 2014 Apr 10 7
17 24753255 Tumor necrosis factor (TNF)-α induction of CXCL10 in endothelial cells requires protein arginine methyltransferase 5 (PRMT5)-mediated nuclear factor (NF)-κB p65 methylation. 2014 May 30 1
18 23087373 The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB. 2013 Jan 7 1
19 23224434 The tumor suppressor protein menin inhibits NF-κB-mediated transactivation through recruitment of Sirt1 in hepatocellular carcinoma. 2013 Mar 2
20 23454124 Glucose-independent persistence of PAI-1 gene expression and H3K4 tri-methylation in type 1 diabetic mouse endothelium: implication in metabolic memory. 2013 Mar 29 1
21 23536830 The N terminus of orf virus-encoded protein 002 inhibits acetylation of NF-κB p65 by preventing Ser(276) phosphorylation. 2013 2
22 23597856 Poly(ADP-ribose) polymerase-1-induced NAD(+) depletion promotes nuclear factor-κB transcriptional activity by preventing p65 de-acetylation. 2013 Aug 1
23 23797602 PHF20 regulates NF-κB signalling by disrupting recruitment of PP2A to p65. 2013 3
24 23904479 Role of lysine methylation of NF-κB in differential gene regulation. 2013 Aug 13 1
25 24189064 Bromodomain and extraterminal (BET) protein inhibition suppresses human T cell leukemia virus 1 (HTLV-1) Tax protein-mediated tumorigenesis by inhibiting nuclear factor κB (NF-κB) signaling. 2013 Dec 13 2
26 21706061 Regulation of NF-κB activity by competition between RelA acetylation and ubiquitination. 2012 Feb 2 1
27 22044919 Resveratrol inhibits interleukin 1β-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-κB activity. 2012 Jan 15 1
28 22249179 New molecular bridge between RelA/p65 and NF-κB target genes via histone acetyltransferase TIP60 cofactor. 2012 Mar 2 2
29 22261743 Monoubiquitination of nuclear RelA negatively regulates NF-κB activity independent of proteasomal degradation. 2012 Jun 1
30 22715377 Phosphorylation of p65(RelA) on Ser(547) by ATM represses NF-κB-dependent transcription of specific genes after genotoxic stress. 2012 1
31 22860050 Regulation of nuclear factor κB (NF-κB) transcriptional activity via p65 acetylation by the chaperonin containing TCP1 (CCT). 2012 1
32 21131967 Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling. 2011 Jan 1
33 21245135 NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance. 2011 Mar 18 1
34 21515635 Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling. 2011 Aug 1
35 21795584 Bharangin, a diterpenoid quinonemethide, abolishes constitutive and inducible nuclear factor-κB (NF-κB) activation by modifying p65 on cysteine 38 residue and reducing inhibitor of nuclear factor-κB α kinase activation, leading to suppression of NF-κB-regulated gene expression and sensitization of tumor cells to chemotherapeutic agents. 2011 Nov 1
36 20064247 Acetylation of p65 at lysine 314 is important for late NF-kappaB-dependent gene expression. 2010 Jan 11 5
37 20080798 Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65. 2010 Jan 5 2
38 20160011 Functional interplay between acetylation and methylation of the RelA subunit of NF-kappaB. 2010 May 9
39 20855868 Beyond the enhanceosome: cluster of novel κB sites downstream of the human IFN-β gene is essential for lipopolysaccharide-induced gene activation. 2010 Dec 16 1
40 19103749 Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA. 2009 Mar 3
41 19262565 Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunit. 2009 Apr 22 2
42 19864627 Regulation of NF-kappaB activity through lysine monomethylation of p65. 2009 Nov 10 2
43 18263619 Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65. 2008 Mar 4
44 18329615 Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation. 2008 Mar 13 1
45 17371260 Impact of post-translational modifications of proteins on the inflammatory process. 2007 Apr 1
46 16424386 Tax ubiquitylation and sumoylation control critical cytoplasmic and nuclear steps of NF-kappaB activation. 2006 May 15 2
47 16926151 Suberoylanilide hydroxamic acid induces Akt-mediated phosphorylation of p300, which promotes acetylation and transcriptional activation of RelA/p65. 2006 Oct 20 4
48 17049505 Mechanistic aspects of apoptosis induction by l-lysine in both HTLV-1-positive and -negative cell lines. 2006 Dec 1 1
49 15972680 Endotoxin tolerance disrupts chromatin remodeling and NF-kappaB transactivation at the IL-1beta promoter. 2005 Jul 1 1
50 16111893 Assessing acetylation of NF-kappaB. 2005 Aug 1