| 1 |
33847389 | Pharmacogenomics and Morphine. | 2021 Sep |
2 |
| 2 |
33008919 | Arginine-259 of UGT2B7 Confers UDP-Sugar Selectivity. | 2020 Dec |
1 |
| 3 |
30300922 | Influence of OCT1 Ontogeny and Genetic Variation on Morphine Disposition in Critically Ill Neonates: Lessons From PBPK Modeling and Clinical Study. | 2019 Mar |
2 |
| 4 |
30421550 | Prolonged central apnoea after intravenous morphine administration in a 12-year-old male with a UGT1A1 loss-of-function polymorphism. | 2019 Jan |
1 |
| 5 |
30709768 | Morphine biotransformation genes and neonatal clinical factors predicted behaviour problems in very preterm children at 18 months. | 2019 Feb |
1 |
| 6 |
31607718 | Roles of UGT2B7 C802T gene polymorphism on the efficacy of morphine treatment on cancer pain among the Chinese han population. | 2019 Oct |
6 |
| 7 |
29164523 | Identification of Uridine 5'-Diphosphate-Glucuronosyltransferases Responsible for the Glucuronidation of Mirabegron, a Potent and Selective β3-Adrenoceptor Agonist, in Human Liver Microsomes. | 2018 Jun |
1 |
| 8 |
29172026 | Effect of non-prohibited drugs on the phase II metabolic profile of morphine. An in vitro investigation for doping control purposes. | 2018 Jun |
1 |
| 9 |
29241692 | In vitro inhibitory effects of major bioactive constituents of Andrographis paniculata, Curcuma longa and Silybum marianum on human liver microsomal morphine glucuronidation: A prediction of potential herb-drug interactions arising from andrographolide, curcumin and silybin inhibition in humans. | 2018 Feb |
1 |
| 10 |
29363349 | Drug metabolism in early infancy: opioids as an illustration. | 2018 Mar |
1 |
| 11 |
29695616 | Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study. | 2018 Jul |
1 |
| 12 |
29920988 | PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants. | 2018 Jul |
2 |
| 13 |
28063968 | Lack of genetic association between OCT1, ABCB1, and UGT2B7 variants and morphine pharmacokinetics. | 2017 Mar 1 |
1 |
| 14 |
28418861 | Brain-derived neurotrophic factor involved epigenetic repression of UGT2B7 in colorectal carcinoma: A mechanism to alter morphine glucuronidation in tumor. | 2017 Apr 25 |
3 |
| 15 |
28552915 | The regioselective glucuronidation of morphine by dimerized human UGT2B7, 1A1, 1A9 and their allelic variants. | 2017 Aug |
5 |
| 16 |
26751618 | Oral Morphine Pharmacokinetic in Obesity: The Role of P-Glycoprotein, MRP2, MRP3, UGT2B7, and CYP3A4 Jejunal Contents and Obesity-Associated Biomarkers. | 2016 Mar 7 |
1 |
| 17 |
27847477 | Reverse of Acute and Chronic Morphine Tolerance by Lithocholic Acid via Down-Regulating UGT2B7. | 2016 |
6 |
| 18 |
28256933 | Association between UGT2B7 gene polymorphisms and fentanyl sensitivity in patients undergoing painful orthognathic surgery. | 2016 Jan-Dec |
2 |
| 19 |
25713207 | Induction of human UDP-Glucuronosyltransferase 2B7 gene expression by cytotoxic anticancer drugs in liver cancer HepG2 cells. | 2015 May |
1 |
| 20 |
25770680 | Homo- and hetero-dimerization of human UDP-glucuronosyltransferase 2B7 (UGT2B7) wild type and its allelic variants affect zidovudine glucuronidation activity. | 2015 May 1 |
1 |
| 21 |
26053558 | In vitro glucuronidation of aprepitant: a moderate inhibitor of UGT2B7. | 2015 |
2 |
| 22 |
24459244 | Morphine glucuronidation and glucosidation represent complementary metabolic pathways that are both catalyzed by UDP-glucuronosyltransferase 2B7: kinetic, inhibition, and molecular modeling studies. | 2014 Apr |
3 |
| 23 |
24703092 | Influence of UGT2B7, OPRM1 and ABCB1 gene polymorphisms on postoperative morphine consumption. | 2014 Nov |
3 |
| 24 |
25340733 | Effect of UGT2B7 -900G>A (-842G>A; rs7438135) on morphine glucuronidation in preterm newborns: results from a pilot cohort. | 2014 |
5 |
| 25 |
25278738 | Pharmacogenomics study in a Taiwan methadone maintenance cohort. | 2013 Dec |
1 |
| 26 |
22240840 | The effects of N-glycosylation on the glucuronidation of zidovudine and morphine by UGT2B7 expressed in HEK293 cells. | 2012 |
2 |
| 27 |
22430884 | Genotypic screening of the main opiate-related polymorphisms in a cohort of 139 sickle cell disease patients. | 2012 May |
1 |
| 28 |
22435749 | Protein quantification of UDP-glucuronosyltransferases 1A1 and 2B7 in human liver microsomes by LC-MS/MS and correlation with glucuronidation activities. | 2012 Sep |
2 |
| 29 |
19466410 | Association of UGT2B7 and ABCB1 genotypes with morphine-induced adverse drug reactions in Japanese patients with cancer. | 2010 Jan |
2 |
| 30 |
20071451 | Molecular cloning of the baboon UDP-glucuronosyltransferase 2B gene family and their activity in conjugating morphine. | 2010 Apr |
1 |
| 31 |
17722074 | Pharmacogenetics of morphine: Potential implications in sickle cell disease. | 2008 Mar |
1 |
| 32 |
17724700 | UGT2B7 promoter variant -840G>A contributes to the variability in hepatic clearance of morphine in patients with sickle cell disease. | 2008 Mar |
7 |
| 33 |
18187562 | Contribution of UDP-glucuronosyltransferase 1A1 and 1A8 to morphine-6-glucuronidation and its kinetic properties. | 2008 Apr |
5 |
| 34 |
17495417 | Morphine glucuronosyltransferase activity in human liver microsomes is inhibited by a variety of drugs that are co-administered with morphine. | 2007 Apr |
2 |
| 35 |
16381668 | Selectivity of substrate (trifluoperazine) and inhibitor (amitriptyline, androsterone, canrenoic acid, hecogenin, phenylbutazone, quinidine, quinine, and sulfinpyrazone) "probes" for human udp-glucuronosyltransferases. | 2006 Mar |
1 |
| 36 |
16679387 | Inhibition of UDP-glucuronosyltransferase 2b7-catalyzed morphine glucuronidation by ketoconazole: dual mechanisms involving a novel noncompetitive mode. | 2006 Aug |
4 |
| 37 |
15611481 | Modulation of UDP-glucuronosyltransferase function by cytochrome P450: evidence for the alteration of UGT2B7-catalyzed glucuronidation of morphine by CYP3A4. | 2005 Mar |
6 |
| 38 |
16045647 | Genetic variability and clinical efficacy of morphine. | 2005 Aug |
3 |
| 39 |
16103897 | Clinical response to morphine in cancer patients and genetic variation in candidate genes. | 2005 |
2 |
| 40 |
16215614 | [Genetic variation-- important for the clinical effect of opioids?]. | 2005 Oct 6 |
1 |
| 41 |
15001974 | A novel functional polymorphism in the uridine diphosphate-glucuronosyltransferase 2B7 promoter with significant impact on promoter activity. | 2004 Mar |
3 |
| 42 |
12629580 | Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients. | 2003 |
2 |
| 43 |
12657745 | Glucuronidation of 1'-hydroxyestragole (1'-HE) by human UDP-glucuronosyltransferases UGT2B7 and UGT1A9. | 2003 May |
1 |
| 44 |
12695358 | Sequence variability and candidate gene analysis in two cancer patients with complex clinical outcomes during morphine therapy. | 2003 May |
2 |
| 45 |
12756209 | The effect of incubation conditions on the enzyme kinetics of udp-glucuronosyltransferases. | 2003 Jun |
1 |
| 46 |
12811366 | A pharmacogenetic study of uridine diphosphate-glucuronosyltransferase 2B7 in patients receiving morphine. | 2003 Jun |
5 |
| 47 |
12920162 | Isoform selectivity and kinetics of morphine 3- and 6-glucuronidation by human udp-glucuronosyltransferases: evidence for atypical glucuronidation kinetics by UGT2B7. | 2003 Sep |
2 |
| 48 |
12920168 | Evaluation of 3'-azido-3'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: specificity and influence of the UGT2B7*2 polymorphism. | 2003 Sep |
4 |
| 49 |
14508389 | Interpretation of the presence of 6-monoacetylmorphine in the absence of morphine-3-glucuronide in urine samples: evidence of heroin abuse. | 2003 Oct |
1 |
| 50 |
14746343 | Formation of highly analgesic morphine-6-glucuronide following physiologic concentration of morphine in human brain. | 2003 Dec |
1 |