Pemetrexed

solute carrier family 46 member 1 ; Homo sapiens







19 Article(s)
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Pub. Year
#Total Relationships
1 34040256 Structural basis of antifolate recognition and transport by PCFT. 2021 Jul 1
2 32493992 Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds. 2020 Aug 1
3 31167838 Clinical Extrapolation of the Effects of Dolutegravir and Other HIV Integrase Inhibitors on Folate Transport Pathways. 2019 Aug 1
4 29127457 The promise and challenges of exploiting the proton-coupled folate transporter for selective therapeutic targeting of cancer. 2018 Jan 2
5 29167151 Substituted-cysteine accessibility and cross-linking identify an exofacial cleft in the 7th and 8th helices of the proton-coupled folate transporter (SLC46A1). 2018 Mar 1 1
6 29326243 Concentrative Transport of Antifolates Mediated by the Proton-Coupled Folate Transporter (SLC46A1); Augmentation by a HEPES Buffer. 2018 Mar 1
7 28945836 Role of proton-coupled folate transporter in pemetrexed resistance of mesothelioma: clinical evidence and new pharmacological tools. 2017 Nov 1 2
8 26837243 Targeting Nonsquamous Nonsmall Cell Lung Cancer via the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]Pyrimidine Thienoyl Antifolates. 2016 Apr 2
9 27251438 Role of the tryptophan residues in proton-coupled folate transporter (PCFT-SLC46A1) function. 2016 Jul 1 1
10 24396145 The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer. 2014 Apr 2
11 24745983 Biology of the major facilitative folate transporters SLC19A1 and SLC46A1. 2014 3
12 23552283 Role of the fourth transmembrane domain in proton-coupled folate transporter function as assessed by the substituted cysteine accessibility method. 2013 Jun 15 1
13 22345511 A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding. 2012 May 1 4
14 22954694 The human proton-coupled folate transporter: Biology and therapeutic applications to cancer. 2012 Dec 2
15 21940787 Therapeutic targeting of a novel 6-substituted pyrrolo [2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by the proton-coupled folate transporter. 2011 Dec 4
16 20601456 Targeting the proton-coupled folate transporter for selective delivery of 6-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of de novo purine biosynthesis in the chemotherapy of solid tumors. 2010 Oct 5
17 18524888 The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier. 2008 Sep 5
18 17308042 Pemetrexed: biochemical and cellular pharmacology, mechanisms, and clinical applications. 2007 Feb 2
19 17340171 The molecular identity and characterization of a Proton-coupled Folate Transporter--PCFT; biological ramifications and impact on the activity of pemetrexed. 2007 Mar 4