Cisplatin

mutL homolog 1 ; Homo sapiens







41 Article(s)
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1 32922493 A Preliminary Study of NER and MMR Pathways Involved in Chemotherapy Response in Bladder Transitional Cell Carcinoma: Impact on progression-free survival. 2020 Winter 1
2 31235597 EBV infection is associated with histone bivalent switch modifications in squamous epithelial cells. 2019 Jul 9 1
3 30594176 MLH1 enhances the sensitivity of human endometrial carcinoma cells to cisplatin by activating the MLH1/c-Abl apoptosis signaling pathway. 2018 Dec 29 5
4 28536927 Involvement of the DNA mismatch repair system in cisplatin sensitivity of testicular germ cell tumours. 2017 Aug 2
5 27823983 Genomic profiling is predictive of response to cisplatin treatment but not to PI3K inhibition in bladder cancer patient-derived xenografts. 2016 Nov 22 1
6 26191250 DNA methylation of hMLH1 correlates with the clinical response to cisplatin after a surgical resection in Non-small cell lung cancer. 2015 8
7 24289605 No relationship between the amount of DNA damage and the level of hMLH1 and RASSF1A gene expression in bladder cancer cells treated with cisplatin and gemcitabine. 2013 3
8 22249249 Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling. 2012 Oct 18 1
9 22737591 Molecular signaling mechanisms of apoptosis in hereditary non-polyposis colorectal cancer. 2012 Jun 15 1
10 21064154 A CRM1-dependent nuclear export pathway is involved in the regulation of MutLα subcellular localization. 2011 Feb 1
11 21875463 [Reversal effect of 5-Aza-dc on cisplatin-resistance in human NSCLC cells in vitro]. 2011 May 2
12 20470425 Decreased transcription-coupled nucleotide excision repair capacity is associated with increased p53- and MLH1-independent apoptosis in response to cisplatin. 2010 May 14 1
13 23136600 Human MLH1 status can potentially predict cisplatin sensitivity but not microsatellite instability in head and neck squamous cell carcinoma cells. 2010 Jan 4
14 19259094 Combined inhibition of DNA methylation and histone acetylation enhances gene re-expression and drug sensitivity in vivo. 2009 Mar 10 2
15 19603033 MLH1 expression sensitises ovarian cancer cells to cell death mediated by XIAP inhibition. 2009 Jul 21 4
16 18683754 [Influence of mifepristone on DNA repair genes and cisplatin sensitivity in human ovarian cancer drug-resistance cells]. 2008 Feb 1
17 19175039 Analysis of hMLH1 and hMSH2 expression in cisplatin-treated ovarian cancer patients. 2008 Dec 2
18 17276589 Hsp27, Hsp70 and mismatch repair proteins hMLH1 and hMSH2 expression in peripheral blood lymphocytes from healthy subjects and cancer patients. 2007 Jul 8 1
19 16143448 DNA damage and repair in peripheral blood lymphocytes from healthy individuals and cancer patients: a pilot study on the implications in the clinical response to chemotherapy. 2006 Jul 28 1
20 16716446 Mismatch repair system (MMR) status correlates with response and survival in non-small cell lung cancer (NSCLC) patients. 2006 Jul 1
21 16273226 Presence of MLH1 protein aggravates the potential of the HSP90 inhibitor radicicol to sensitize tumor cells to cisplatin. 2005 Dec 6
22 15506976 Epigenetic approaches to cancer therapy. 2004 Dec 3
23 12736115 Loss of hMLH1 expression correlates with improved survival in stage III-IV ovarian cancer patients. 2003 May 1
24 14555508 Reduced MLH1 expression after chemotherapy is an indicator for poor prognosis in esophageal cancers. 2003 Oct 1 4
25 12023887 Ascorbate up-regulates MLH1 (Mut L homologue-1) and p73: implications for the cellular response to DNA damage. 2002 Jun 1 3
26 12441268 Retention of activity by the new generation platinum agent AMD0473 in four human tumour cell lines possessing acquired resistance to oxaliplatin. 2002 Nov 1
27 11925933 Analysis of gene expression profiles associated with cisplatin resistance in human ovarian cancer cell lines and tissues using cDNA microarray. 2001 Dec 1
28 10918568 Spontaneous development of drug resistance: mismatch repair and p53 defects in resistance to cisplatin in human tumor cells. 2000 Jun 29 3
29 9889125 Dependence on RAD52 and RAD1 for anticancer drug resistance mediated by inactivation of mismatch repair genes. 1999 Jan 14 5
30 10048977 Expression of DNA repair proteins hMSH2, hMSH6, hMLH1, O6-methylguanine-DNA methyltransferase and N-methylpurine-DNA glycosylase in melanoma cells with acquired drug resistance. 1999 Mar 1 2
31 10327053 A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer. 1999 Apr 8 4
32 10360646 Loss of DNA mismatch repair facilitates reactivation of a reporter plasmid damaged by cisplatin. 1999 May 1
33 10408835 Mismatch repair deficiency is associated with resistance to DNA minor groove alkylating agents. 1999 May 1
34 10626357 Specificity of platinum-DNA adduct repair. 1999 Oct 1
35 9647613 Ongoing and unsaid on oxaliplatin: the hope. 1998 Jun 1
36 9721864 The role of hMLH1, hMSH3, and hMSH6 defects in cisplatin and oxaliplatin resistance: correlation with replicative bypass of platinum-DNA adducts. 1998 Aug 15 3
37 9157971 In vitro and in vivo resistance to cisplatin in cells that have lost DNA mismatch repair. 1997 May 15 1
38 9233776 hMLH1 expression and cellular responses of ovarian tumour cells to treatment with cytotoxic anticancer agents. 1997 Jul 3 5
39 9815561 Resistance to cytotoxic drugs in DNA mismatch repair-deficient cells. 1997 Oct 1
40 8674066 Loss of DNA mismatch repair in acquired resistance to cisplatin. 1996 Jul 1 1
41 8895738 The role of DNA mismatch repair in platinum drug resistance. 1996 Nov 1 2