Bortezomib

BCL2 like 1 ; Homo sapiens







29 Article(s)
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1 34608124 Severe cellular stress activates apoptosis independently of p53 in osteosarcoma. 2021 Oct 4 1
2 30845975 The IAP antagonist birinapant potentiates bortezomib anti-myeloma activity in vitro and in vivo. 2019 Mar 7 1
3 29057477 The MIP-1α autocrine loop contributes to decreased sensitivity to anticancer drugs. 2018 May 1
4 26939706 Expression Profile of BCL-2, BCL-XL, and MCL-1 Predicts Pharmacological Response to the BCL-2 Selective Antagonist Venetoclax in Multiple Myeloma Models. 2016 May 2
5 26354682 Hypoxia Promotes Synergy between Mitomycin C and Bortezomib through a Coordinated Process of Bcl-xL Phosphorylation and Mitochondrial Translocation of p53. 2015 Dec 3
6 23697845 Bortezomib inhibits proteasomal degradation of IκBα and induces mitochondrial dependent apoptosis in activated B-cell diffuse large B-cell lymphoma. 2014 Feb 1
7 24333736 Capillarisin inhibits constitutive and inducible STAT3 activation through induction of SHP-1 and SHP-2 tyrosine phosphatases. 2014 Apr 1 1
8 24486574 Role of Bcl-xL/Beclin-1 in interplay between apoptosis and autophagy in oxaliplatin and bortezomib-induced cell death. 2014 Mar 15 2
9 23449448 Phosphorylation of signal transducer and activator of transcription 1 reduces bortezomib-mediated apoptosis in cancer cells. 2013 Feb 28 1
10 23536725 Profiling bortezomib resistance identifies secondary therapies in a mouse myeloma model. 2013 Jun 1
11 24156429 [Effect of PCI-32765 and bortezomib on proliferation and apoptosis of B-cell tumor cell lines and its mechanisms]. 2013 Oct 1
12 22391178 Effects of arsenic trioxide combined with bortezomib on apoptosis of multiple myeloma cell line KM3 and its mechanisms. 2012 Feb 2
13 21247388 Bortezomib as the first proteasome inhibitor anticancer drug: current status and future perspectives. 2011 Mar 1
14 21357440 Mechanisms of drug sensitization to TRA-8, an agonistic death receptor 5 antibody, involve modulation of the intrinsic apoptotic pathway in human breast cancer cells. 2011 Apr 1
15 21454712 Noxa/Bcl-2 protein interactions contribute to bortezomib resistance in human lymphoid cells. 2011 May 20 1
16 20051518 The anti-apoptotic protein BCL2L1/Bcl-xL is neutralized by pro-apoptotic PMAIP1/Noxa in neuroblastoma, thereby determining bortezomib sensitivity independent of prosurvival MCL1 expression. 2010 Mar 5 10
17 19100720 Cooperation between Apo2L/TRAIL and bortezomib in multiple myeloma apoptosis. 2009 Mar 1 2
18 19372569 Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model. 2009 Apr 1
19 18566236 Bortezomib induces apoptosis via Bim and Bik up-regulation and synergizes with cisplatin in the killing of head and neck squamous cell carcinoma cells. 2008 Jun 1
20 18594829 Docetaxel and bortezomib downregulate Bcl-2 and sensitize PC-3-Bcl-2 expressing prostate cancer cells to irradiation. 2008 Oct 1
21 17541428 Therapeutic window for melanoma treatment provided by selective effects of the proteasome on Bcl-2 proteins. 2007 Sep 1
22 17568816 PS-341 or a combination of arsenic trioxide and interferon-alpha inhibit growth and induce caspase-dependent apoptosis in KSHV/HHV-8-infected primary effusion lymphoma cells. 2007 Aug 1
23 16446371 PS-341 (bortezomib) induces lysosomal cathepsin B release and a caspase-2-dependent mitochondrial permeabilization and apoptosis in human pancreatic cancer cells. 2006 Apr 28 1
24 16904634 Histone deacetylase inhibitor trichostatin A and proteasome inhibitor PS-341 synergistically induce apoptosis in pancreatic cancer cells. 2006 Oct 6 1
25 15531918 Proteasome inhibitor PS-341 causes cell growth arrest and apoptosis in human glioblastoma multiforme (GBM). 2005 Jan 13 1
26 15781649 Predominant Bcl-XL knockdown disables antiapoptotic mechanisms: tumor necrosis factor-related apoptosis-inducing ligand-based triple chemotherapy overcomes chemoresistance in pancreatic cancer cells in vitro. 2005 Mar 15 2
27 15039284 Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms. 2004 Jul 15 1
28 12902978 The proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and caspase 9-negative or Bcl-xL overexpressing cells. 2003 Aug 7 2
29 12226754 The function of multiple IkappaB : NF-kappaB complexes in the resistance of cancer cells to Taxol-induced apoptosis. 2002 Sep 19 1