Dichloroacetic Acid

pyruvate dehydrogenase kinase 2 ; Homo sapiens







17 Article(s)
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1 34445316 Suppression of Pyruvate Dehydrogenase Kinase by Dichloroacetate in Cancer and Skeletal Muscle Cells Is Isoform Specific and Partially Independent of HIF-1α. 2021 Aug 10 1
2 31597953 Dichloroacetate restores colorectal cancer chemosensitivity through the p53/miR-149-3p/PDK2-mediated glucose metabolic pathway. 2020 Jan 2
3 31624634 GSTZ1 genotypes correlate with dichloroacetate pharmacokinetics and chronic side effects in multiple myeloma patients in a pilot phase 2 clinical trial. 2019 Dec 3
4 28881758 Suppression of pyruvate dehydrogenase kinase-2 re-sensitizes paclitaxel-resistant human lung cancer cells to paclitaxel. 2017 Aug 8 1
5 26607904 Activation of mitochondrial oxidation by PDK2 inhibition reverses cisplatin resistance in head and neck cancer. 2016 Feb 1 1
6 27323896 Pro-haloacetate Nanoparticles for Efficient Cancer Therapy via Pyruvate Dehydrogenase Kinase Modulation. 2016 Jun 21 1
7 25601413 Differential inhibition of PDKs by phenylbutyrate and enhancement of pyruvate dehydrogenase complex activity by combination with dichloroacetate. 2015 Sep 2
8 24747400 Dichloroacetate prevents restenosis in preclinical animal models of vessel injury. 2014 May 29 1
9 25482950 Targeting of two aspects of metabolism in breast cancer treatment. 2014 2
10 21283817 Chronic CSE treatment induces the growth of normal oral keratinocytes via PDK2 upregulation, increased glycolysis and HIF1α stabilization. 2011 Jan 19 1
11 19147752 Mitochondrial mutations contribute to HIF1alpha accumulation via increased reactive oxygen species and up-regulated pyruvate dehydrogenease kinase 2 in head and neck squamous cell carcinoma. 2009 Jan 15 1
12 19833728 Pivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetate. 2009 Dec 4 3
13 18627174 Allosteric coupling in pyruvate dehydrogenase kinase 2. 2008 Aug 12 1
14 17222789 A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. 2007 Jan 1
15 17544412 Amino acid residues responsible for the recognition of dichloroacetate by pyruvate dehydrogenase kinase 2. 2007 Jun 26 3
16 10748134 Marked differences between two isoforms of human pyruvate dehydrogenase kinase. 2000 May 26 4
17 9405293 Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex. 1998 Jan 1 1