| 1 |
34974185 | Proline-serine-threonine-repeat region of MDC1 mediates Chk1 phosphorylation and the DNA double-strand break repair. | 2022 Feb |
1 |
| 2 |
32991949 | Reality CHEK: Understanding the biology and clinical potential of CHK1. | 2021 Jan 28 |
2 |
| 3 |
33466733 | MBNL2 Regulates DNA Damage Response via Stabilizing p21. | 2021 Jan 14 |
2 |
| 4 |
33503415 | Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A. | 2021 Jan 26 |
1 |
| 5 |
33591599 | Design, Synthesis, and Biological Evaluation of Orally Bioavailable CHK1 Inhibitors Active against Acute Myeloid Leukemia. | 2021 May 6 |
1 |
| 6 |
33870196 | Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells. | 2021 Jun |
1 |
| 7 |
34158506 | The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation. | 2021 Jun 22 |
1 |
| 8 |
32371584 | CHK1/2 Inhibitor Prexasertib Suppresses NOTCH Signaling and Enhances Cytotoxicity of Cisplatin and Radiation in Head and Neck Squamous Cell Carcinoma. | 2020 Jun |
2 |
| 9 |
32653524 | Estimation of the ligand-binding free energy of checkpoint kinase 1 via non-equilibrium MD simulations. | 2020 Nov |
2 |
| 10 |
33007920 | Fumonisin B1 Epigenetically Regulates PTEN Expression and Modulates DNA Damage Checkpoint Regulation in HepG2 Liver Cells. | 2020 Sep 30 |
1 |
| 11 |
30362603 | Oncostatic treatment effect of triple negative breast cancer cell line with copper (I)-nicotinate complex. | 2019 Mar |
1 |
| 12 |
30470507 | The Ataxia telangiectasia-mutated and Rad3-related protein kinase regulates cellular hydrogen sulfide concentrations. | 2019 Jan |
2 |
| 13 |
31092016 | Inhibition of CHK 1 (Checkpoint Kinase 1) Elicits Therapeutic Effects in Pulmonary Arterial Hypertension. | 2019 Aug |
2 |
| 14 |
29695073 | Design, Synthesis, and Docking Studies of New Torin2 Analogs as Potential ATR/mTOR Kinase Inhibitors. | 2018 Apr 24 |
1 |
| 15 |
29954829 | Src activation by Chk1 promotes actin patch formation and prevents chromatin bridge breakage in cytokinesis. | 2018 Sep 3 |
1 |
| 16 |
30119887 | Insulin-like growth factor I receptor regulates the radiation-induced G2/M checkpoint in HeLa cells. | 2018 Sep 18 |
1 |
| 17 |
30237857 | Trisenox disrupts MDM2-DAXX-HAUSP complex and activates p53, cell cycle regulation and apoptosis in acute leukemia cells. | 2018 Sep 4 |
2 |
| 18 |
28430840 | Checkpoint-dependent phosphorylation of Med1/TRAP220 in response to DNA damage. | 2017 Jun 1 |
2 |
| 19 |
28986587 | The drinking water contaminant dibromoacetonitrile delays G1-S transition and suppresses Chk1 activation at broken replication forks. | 2017 Oct 6 |
1 |
| 20 |
28991639 | Haemanthamine alters sodium butyrate-induced histone acetylation, p21WAF1/Cip1 expression, Chk1 and Chk2 activation and leads to increased growth inhibition and death in A2780 ovarian cancer cells. | 2017 Nov 15 |
1 |
| 21 |
29021254 | Checkpoint kinase 1-induced phosphorylation of O-linked β-N-acetylglucosamine transferase regulates the intermediate filament network during cytokinesis. | 2017 Dec 1 |
1 |
| 22 |
29092815 | The kinase domain residue serine 173 of Schizosaccharomyces pombe Chk1 kinase is critical for the response to DNA replication stress. | 2017 Dec 15 |
4 |
| 23 |
29163782 | BMI1 reduces ATR activation and signalling caused by hydroxyurea. | 2017 Oct 27 |
1 |
| 24 |
29221122 | Checkpoint kinase 1 inhibition sensitises transformed cells to dihydroorotate dehydrogenase inhibition. | 2017 Nov 10 |
1 |
| 25 |
27643582 | Comparison of the Radiosensitizing Effect of ATR, ATM and DNA-PK Kinase Inhibitors on Cervical Carcinoma Cells. | 2016 |
1 |
| 26 |
25468710 | Untangling the ATR-CHEK1 network for prognostication, prediction and therapeutic target validation in breast cancer. | 2015 Mar |
1 |
| 27 |
25690891 | CHK1-driven histone H3.3 serine 31 phosphorylation is important for chromatin maintenance and cell survival in human ALT cancer cells. | 2015 Mar 11 |
1 |
| 28 |
25809478 | Phosphorylation of Minichromosome Maintenance 3 (MCM3) by Checkpoint Kinase 1 (Chk1) Negatively Regulates DNA Replication and Checkpoint Activation. | 2015 May 8 |
1 |
| 29 |
26039276 | KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage. | 2015 Jun 3 |
2 |
| 30 |
26161259 | Triptolide potentiates lung cancer cells to cisplatin-induced apoptosis by selectively inhibiting the NER activity. | 2015 |
2 |
| 31 |
26441204 | Benfluron Induces Cell Cycle Arrest, Apoptosis and Activation of p53 Pathway in MOLT-4 Leukemic Cells. | 2015 |
1 |
| 32 |
23748345 | Pim kinases phosphorylate Chk1 and regulate its functions in acute myeloid leukemia. | 2014 Feb |
5 |
| 33 |
24197116 | Mitotic arrest by tumor suppressor RASSF1A is regulated via CHK1 phosphorylation. | 2014 Jan |
4 |
| 34 |
25015292 | Chk1 protects against chromatin bridges by constitutively phosphorylating BLM serine 502 to inhibit BLM degradation. | 2014 Sep 15 |
2 |
| 35 |
23321637 | Chk1 and Mps1 jointly regulate correction of merotelic kinetochore attachments. | 2013 Mar 1 |
1 |
| 36 |
23550703 | Global analysis of phosphorylation of tau by the checkpoint kinases Chk1 and Chk2 in vitro. | 2013 Jun 7 |
1 |
| 37 |
23861943 | CK1δ kinase activity is modulated by Chk1-mediated phosphorylation. | 2013 |
1 |
| 38 |
24072747 | Chk1 targeting reactivates PP2A tumor suppressor activity in cancer cells. | 2013 Nov 15 |
1 |
| 39 |
24081328 | Akt switches TopBP1 function from checkpoint activation to transcriptional regulation through phosphoserine binding-mediated oligomerization. | 2013 Dec |
1 |
| 40 |
21765472 | Cdk-mediated phosphorylation of Chk1 is required for efficient activation and full checkpoint proficiency in response to DNA damage. | 2012 Mar 1 |
1 |
| 41 |
22357623 | P90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferation. | 2012 Apr |
15 |
| 42 |
22456510 | c-Jun N-terminal kinase-mediated Rad18 phosphorylation facilitates Polη recruitment to stalled replication forks. | 2012 May |
1 |
| 43 |
22496453 | Roles of Kruppel-associated Box (KRAB)-associated Co-repressor KAP1 Ser-473 Phosphorylation in DNA Damage Response. | 2012 Jun 1 |
1 |
| 44 |
22505024 | Chk1 phosphorylates the tumour suppressor Mig-6, regulating the activation of EGF signalling. | 2012 May 16 |
2 |
| 45 |
22743332 | BRCA1-dependent Chk1 phosphorylation triggers partial chromatin disassociation of phosphorylated Chk1 and facilitates S-phase cell cycle arrest. | 2012 Nov |
2 |
| 46 |
22842784 | ATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeres. | 2012 Aug 15 |
1 |
| 47 |
22855742 | Autoregulatory mechanisms of phosphorylation of checkpoint kinase 1. | 2012 Aug 1 |
3 |
| 48 |
20840867 | ERK1 and ERK2 kinases activate hydroxyurea-induced S-phase checkpoint in MCF7 cells by mediating ATR activation. | 2011 Jan |
1 |
| 49 |
21870291 | Methods for studying checkpoint kinases - Chk1. | 2011 |
4 |
| 50 |
21965652 | Phosphorylation of MCM3 protein by cyclin E/cyclin-dependent kinase 2 (Cdk2) regulates its function in cell cycle. | 2011 Nov 18 |
1 |