| 1 |
35379057 | Elucidating the structure and cytochrome P450-mediated mechanism for novel metabolites of GDC-0575 in rats. | 2022 Mar |
1 |
| 2 |
31512029 | Prexasertib, a checkpoint kinase inhibitor: from preclinical data to clinical development. | 2020 Jan |
1 |
| 3 |
30773012 | Imatinib-Induced Changes in Protein Expression and ATP-Binding Affinities of Kinases in Chronic Myelocytic Leukemia Cells. | 2019 Mar 5 |
1 |
| 4 |
29409053 | CHK1 inhibition in soft-tissue sarcomas: biological and clinical implications. | 2018 Apr 1 |
1 |
| 5 |
27167172 | Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737). | 2016 Jun 9 |
2 |
| 6 |
26437226 | Identification of novel, in vivo active Chk1 inhibitors utilizing structure guided drug design. | 2015 Nov 3 |
2 |
| 7 |
25336189 | Identification of ATR-Chk1 pathway inhibitors that selectively target p53-deficient cells without directly suppressing ATR catalytic activity. | 2014 Dec 15 |
1 |
| 8 |
23483975 | A kinome screen identifies checkpoint kinase 1 (CHK1) as a sensitizer for RRM1-dependent gemcitabine efficacy. | 2013 |
2 |
| 9 |
23535330 | Structure-based design and optimization of 2-aminothiazole-4-carboxamide as a new class of CHK1 inhibitors. | 2013 May 1 |
1 |
| 10 |
23873850 | Combination drug scheduling defines a "window of opportunity" for chemopotentiation of gemcitabine by an orally bioavailable, selective ChK1 inhibitor, GNE-900. | 2013 Oct |
1 |
| 11 |
22374217 | Pyridyl aminothiazoles as potent inhibitors of Chk1 with slow dissociation rates. | 2012 Apr 1 |
1 |
| 12 |
22621920 | ATP depletion triggers acute myeloid leukemia differentiation through an ATR/Chk1 protein-dependent and p53 protein-independent pathway. | 2012 Jul 6 |
2 |
| 13 |
22929806 | CCT244747 is a novel potent and selective CHK1 inhibitor with oral efficacy alone and in combination with genotoxic anticancer drugs. | 2012 Oct 15 |
1 |
| 14 |
20020310 | Structure-based and shape-complemented pharmacophore modeling for the discovery of novel checkpoint kinase 1 inhibitors. | 2010 Jul |
1 |
| 15 |
20053762 | The preclinical pharmacology and therapeutic activity of the novel CHK1 inhibitor SAR-020106. | 2010 Jan |
1 |
| 16 |
20561787 | Design and evaluation of 3,6-di(hetero)aryl imidazo[1,2-a]pyrazines as inhibitors of checkpoint and other kinases. | 2010 Jul 15 |
1 |
| 17 |
19155174 | Development of thioquinazolinones, allosteric Chk1 kinase inhibitors. | 2009 Feb 15 |
1 |
| 18 |
19743875 | Characterization of the CHK1 allosteric inhibitor binding site. | 2009 Oct 20 |
2 |
| 19 |
17502122 | Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of pyrrolo[3,4-a]carbazole-1,3-diones, pyrrolo[3,4-c]carbazole-1,3-diones, and 2-aminopyridazino[3,4-a]pyrrolo[3,4-c]carbazole-1,3,4,7-tetraone. | 2008 Feb |
1 |
| 20 |
17722905 | Synthesis and biological activities of new checkpoint kinase 1 inhibitors structurally related to granulatimide. | 2007 Sep 20 |
1 |
| 21 |
17900896 | Synthesis and evaluation of substituted benzoisoquinolinones as potent inhibitors of Chk1 kinase. | 2007 Nov 15 |
1 |
| 22 |
16289938 | Identification of a buried pocket for potent and selective inhibition of Chk1: prediction and verification. | 2006 Mar 15 |
2 |
| 23 |
16574416 | Identification of chemically diverse Chk1 inhibitors by receptor-based virtual screening. | 2006 Jul 15 |
2 |
| 24 |
16978863 | 3-(Indol-2-yl)indazoles as Chek1 kinase inhibitors: Optimization of potency and selectivity via substitution at C6. | 2006 Dec 1 |
2 |
| 25 |
16996169 | Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of indolylpyrazolones and indolylpyridazinedione. | 2006 Dec |
1 |
| 26 |
15974586 | Structure-based design of novel Chk1 inhibitors: insights into hydrogen bonding and protein-ligand affinity. | 2005 Jun 30 |
1 |
| 27 |
15486189 | Inhibition of Chk1 by the G2 DNA damage checkpoint inhibitor isogranulatimide. | 2004 Oct |
1 |
| 28 |
12191604 | Structural studies with inhibitors of the cell cycle regulatory kinase cyclin-dependent protein kinase 2. | 2002 Feb-Mar |
2 |
| 29 |
12244092 | Structural basis for Chk1 inhibition by UCN-01. | 2002 Nov 29 |
2 |
| 30 |
10761933 | The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation. | 2000 Mar 17 |
1 |