| 1 |
33953402 | Replication stress promotes cell elimination by extrusion. | 2021 May |
1 |
| 2 |
31713291 | Direct regulation of Chk1 protein stability by E3 ubiquitin ligase HUWE1. | 2020 May |
1 |
| 3 |
32647134 | Resistance to the CHK1 inhibitor prexasertib involves functionally distinct CHK1 activities in BRCA wild-type ovarian cancer. | 2020 Aug |
1 |
| 4 |
33269665 | Human CTC1 promotes TopBP1 stability and CHK1 phosphorylation in response to telomere dysfunction and global replication stress. | 2020 Dec |
1 |
| 5 |
31044505 | Combined use of subclinical hydroxyurea and CHK1 inhibitor effectively controls melanoma and lung cancer progression, with reduced normal tissue toxicity compared to gemcitabine. | 2019 Jul |
1 |
| 6 |
28098859 | DNA damage response defect in Williams-Beuren syndrome. | 2017 Mar |
1 |
| 7 |
26876155 | Lovastatin protects keratinocytes from DNA damage-related pro-apoptotic stress responses stimulated by anticancer therapeutics. | 2016 Jun |
2 |
| 8 |
27634334 | DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer. | 2016 Sep 15 |
1 |
| 9 |
25459351 | Development of pharmacodynamic biomarkers for ATR inhibitors. | 2015 Feb |
1 |
| 10 |
24434653 | RRM1 maintains centrosomal integrity via CHK1 and CDK1 signaling during replication stress. | 2014 May 1 |
1 |
| 11 |
24965470 | The ATR signaling pathway is disabled during infection with the parvovirus minute virus of mice. | 2014 Sep 1 |
1 |
| 12 |
25485589 | The leukemia-associated Rho guanine nucleotide exchange factor LARG is required for efficient replication stress signaling. | 2014 |
1 |
| 13 |
24081328 | Akt switches TopBP1 function from checkpoint activation to transcriptional regulation through phosphoserine binding-mediated oligomerization. | 2013 Dec |
1 |
| 14 |
24359526 | Sensitization of human cancer cells to gemcitabine by the Chk1 inhibitor MK-8776: cell cycle perturbation and impact of administration schedule in vitro and in vivo. | 2013 Dec 21 |
1 |
| 15 |
22743332 | BRCA1-dependent Chk1 phosphorylation triggers partial chromatin disassociation of phosphorylated Chk1 and facilitates S-phase cell cycle arrest. | 2012 Nov |
1 |
| 16 |
22753029 | CHK1 activity is required for continuous replication fork elongation but not stabilization of post-replicative gaps after UV irradiation. | 2012 Sep 1 |
1 |
| 17 |
20840867 | ERK1 and ERK2 kinases activate hydroxyurea-induced S-phase checkpoint in MCF7 cells by mediating ATR activation. | 2011 Jan |
1 |
| 18 |
21212274 | TAp73 induction by nitric oxide: regulation by checkpoint kinase 1 (CHK1) and protection against apoptosis. | 2011 Mar 11 |
1 |
| 19 |
21558560 | Critical roles of ring finger protein RNF8 in replication stress responses. | 2011 Jun 24 |
1 |
| 20 |
21615992 | Knock-down of human MutY homolog (hMYH) decreases phosphorylation of checkpoint kinase 1 (Chk1) induced by hydroxyurea and UV treatment. | 2011 May |
2 |
| 21 |
19477925 | Estrogen inhibits ATR signaling to cell cycle checkpoints and DNA repair. | 2009 Jul |
1 |
| 22 |
18084324 | Cdc7 kinase mediates Claspin phosphorylation in DNA replication checkpoint. | 2008 May 29 |
1 |
| 23 |
18448427 | A conserved proliferating cell nuclear antigen-interacting protein sequence in Chk1 is required for checkpoint function. | 2008 Jun 20 |
1 |
| 24 |
17210576 | Phosphatase type 2A-dependent and -independent pathways for ATR phosphorylation of Chk1. | 2007 Mar 9 |
1 |
| 25 |
17726372 | DNA damage-induced accumulation of centrosomal Chk1 contributes to its checkpoint function. | 2007 Oct 15 |
1 |
| 26 |
18089794 | Different S/M checkpoint responses of tumor and non tumor cell lines to DNA replication inhibition. | 2007 Dec 15 |
2 |
| 27 |
16293623 | DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM. | 2006 Jan 20 |
1 |
| 28 |
16431910 | Rapid activation of ATR by ionizing radiation requires ATM and Mre11. | 2006 Apr 7 |
1 |
| 29 |
15539958 | Chk1 is essential for tumor cell viability following activation of the replication checkpoint. | 2005 Jan |
1 |
| 30 |
15665856 | The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. | 2005 Feb |
1 |
| 31 |
12676962 | Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345. | 2003 Jul 4 |
1 |
| 32 |
12714602 | Identification of MCM4 as a target of the DNA replication block checkpoint system. | 2003 Jul 4 |
1 |
| 33 |
12847089 | Caffeine inhibits checkpoint responses without inhibiting the ataxia-telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) protein kinases. | 2003 Sep 26 |
1 |