| 1 |
34953860 | RNA-binding protein RBM28 can translocate from the nucleolus to the nucleoplasm to inhibit the transcriptional activity of p53. | 2022 Feb |
2 |
| 2 |
33669867 | Phosphoinositide 3-Kinase (PI3K) Reactive Oxygen Species (ROS)-Activated Prodrug in Combination with Anthracycline Impairs PI3K Signaling, Increases DNA Damage Response and Reduces Breast Cancer Cell Growth. | 2021 Feb 19 |
1 |
| 3 |
33915913 | Heterogeneities in Cell Cycle Checkpoint Activation Following Doxorubicin Treatment Reveal Targetable Vulnerabilities in TP53 Mutated Ultra High-Risk Neuroblastoma Cell Lines. | 2021 Apr 1 |
1 |
| 4 |
34519926 | Exploring the ATR-CHK1 pathway in the response of doxorubicin-induced DNA damages in acute lymphoblastic leukemia cells. | 2021 Sep 14 |
9 |
| 5 |
32210727 | The Role of CHK1 Varies with the Status of Oestrogen-receptor and Progesterone-receptor in the Targeted Therapy for Breast Cancer. | 2020 |
1 |
| 6 |
31213891 | Estrogen-dependent disruption of intracellular iron metabolism augments the cytotoxic effects of doxorubicin in select breast and ovarian cancer cells. | 2019 |
1 |
| 7 |
31759252 | APC loss affects DNA damage repair causing doxorubicin resistance in breast cancer cells. | 2019 Dec |
1 |
| 8 |
30103170 | Metronomic oral doxorubicin in combination of Chk1 inhibitor MK-8776 for p53-deficient breast cancer treatment. | 2018 Nov |
1 |
| 9 |
26876155 | Lovastatin protects keratinocytes from DNA damage-related pro-apoptotic stress responses stimulated by anticancer therapeutics. | 2016 Jun |
1 |
| 10 |
27888802 | Low dose triptolide reverses chemoresistance in adult acute lymphoblastic leukemia cells via reactive oxygen species generation and DNA damage response disruption. | 2016 Dec 20 |
2 |
| 11 |
25683911 | Chk1 and Wee1 control genotoxic-stress induced G2-M arrest in melanoma cells. | 2015 May |
2 |
| 12 |
25880358 | Enhancer of rudimentary homolog regulates DNA damage response in hepatocellular carcinoma. | 2015 Apr 9 |
1 |
| 13 |
24913980 | Reactive oxygen species- and DNA damage response-dependent NK cell activating ligand upregulation occurs at transcriptional levels and requires the transcriptional factor E2F1. | 2014 Jul 15 |
1 |
| 14 |
25520248 | Over expression of hRad9 protein correlates with reduced chemosensitivity in breast cancer with administration of neoadjuvant chemotherapy. | 2014 Dec 18 |
1 |
| 15 |
22653969 | The checkpoint kinase inhibitor AZD7762 potentiates chemotherapy-induced apoptosis of p53-mutated multiple myeloma cells. | 2012 Aug |
1 |
| 16 |
23076878 | Doxorubicin induces the DNA damage response in cultured human mesenchymal stem cells. | 2012 Nov |
1 |
| 17 |
20623183 | Estrogen receptor beta decreases survival of p53-defective cancer cells after DNA damage by impairing G₂/M checkpoint signaling. | 2011 Jun |
1 |
| 18 |
21512242 | Persimmon leaf extract inhibits the ATM activity during DNA damage response induced by Doxorubicin in A549 lung adenocarcinoma cells. | 2011 |
2 |
| 19 |
19218339 | Identification of potential therapeutic targets in malignant mesothelioma using cell-cycle gene expression analysis. | 2009 Mar |
1 |
| 20 |
19453842 | Cellular effects of genotoxic stress and gene silencing of the checkpoint kinases in human oral cells. | 2009 Aug |
1 |
| 21 |
18071310 | Hsp90-inhibitor geldanamycin abrogates G2 arrest in p53-negative leukemia cell lines through the depletion of Chk1. | 2008 May 15 |
1 |
| 22 |
18698031 | Checkpoint kinase 1 down-regulation by an inducible small interfering RNA expression system sensitized in vivo tumors to treatment with 5-fluorouracil. | 2008 Aug 15 |
1 |
| 23 |
17352464 | Structure-based design, synthesis, and biological evaluation of potent and selective macrocyclic checkpoint kinase 1 inhibitors. | 2007 Apr 5 |
3 |
| 24 |
17544271 | Synthesis and biological evaluation of 4'-(6,7-disubstituted-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-biphenyl-4-ol as potent Chk1 inhibitors. | 2007 Aug 1 |
1 |
| 25 |
17935989 | Macrocyclic ureas as potent and selective Chk1 inhibitors: an improved synthesis, kinome profiling, structure-activity relationships, and preliminary pharmacokinetics. | 2007 Dec 1 |
1 |
| 26 |
16928813 | Differential roles of checkpoint kinase 1, checkpoint kinase 2, and mitogen-activated protein kinase-activated protein kinase 2 in mediating DNA damage-induced cell cycle arrest: implications for cancer therapy. | 2006 Aug |
1 |
| 27 |
17085670 | Schedule-dependent synergy between the heat shock protein 90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin and doxorubicin restores apoptosis to p53-mutant lymphoma cell lines. | 2006 Nov 1 |
1 |
| 28 |
17204173 | [Mechanism of G2/M blockage triggered by activated-Chk1 in regulation of drug-resistance in K562/A02 cell line]. | 2006 Dec |
1 |
| 29 |
15608676 | A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation. | 2005 Feb 17 |
1 |
| 30 |
15707569 | The relative contribution of CHK1 and CHK2 to Adriamycin-induced checkpoint. | 2005 Mar 10 |
6 |
| 31 |
15805289 | RNA silencing of checkpoint regulators sensitizes p53-defective prostate cancer cells to chemotherapy while sparing normal cells. | 2005 Apr 1 |
2 |
| 32 |
15870702 | Two distinct modes of cell death induced by doxorubicin: apoptosis and cell death through mitotic catastrophe accompanied by senescence-like phenotype. | 2005 Jul 14 |
1 |
| 33 |
15489221 | Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species. | 2004 Dec 17 |
2 |
| 34 |
11687952 | Blocking Chk1 expression induces apoptosis and abrogates the G2 checkpoint mechanism. | 2001 Sep-Oct |
2 |