Cisplatin

checkpoint kinase 2 ; Homo sapiens







31 Article(s)
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1 35220216 Characterization of Cisplatin Effects in Lenvatinib-resistant Hepatocellular Carcinoma Cells. 2022 Mar 1
2 35456022 Apoptotic and DNA Damage Effect of 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose in Cisplatin-Resistant Non-Small Lung Cancer Cells via Phosphorylation of H2AX, CHK2 and p53. 2022 Apr 14 1
3 33017201 Could Aberrant Migration Explain Metachronous Germ Cell Tumors? 2021 Feb 1
4 32457423 Kinesin light chain 4 as a new target for lung cancer chemoresistance via targeted inhibition of checkpoint kinases in the DNA repair network. 2020 May 26 2
5 30690027 Notch1 inhibition enhances DNA damage induced by cisplatin in cervical cancer. 2019 Mar 1 1
6 29316526 Part II: New candidates of pyrazole-benzimidazole conjugates as checkpoint kinase 2 (Chk2) inhibitors. 2018 Jan 20 1
7 29761796 Study on the Mechanism of Cell Cycle Checkpoint Kinase 2 (CHEK2) Gene Dysfunction in Chemotherapeutic Drug Resistance of Triple Negative Breast Cancer Cells. 2018 May 15 5
8 27794029 Reversible p53 inhibition prevents cisplatin ototoxicity without blocking chemotherapeutic efficacy. 2017 Jan 1
9 28347251 Feedback regulation of methyl methanesulfonate and ultraviolet-sensitive gene clone 81 via ATM/Chk2 pathway contributes to the resistance of MCF-7 breast cancer cells to cisplatin. 2017 Mar 6
10 28454371 Synergistic effects of a novel lipid-soluble extract from Pinellia pedatisecta Schott and cisplatin on human cervical carcinoma cell lines through the regulation of DNA damage response signaling pathway. 2017 Apr 1
11 28686074 Simultaneous targeting of ATM and Mcl-1 increases cisplatin sensitivity of cisplatin-resistant non-small cell lung cancer. 2017 Aug 3 2
12 27494891 Analysis of the chemotherapeutic effects of a propadiene compound on malignant ovarian cancer cells. 2016 Aug 30 1
13 27984128 DNA damage response in nephrotoxic and ischemic kidney injury. 2016 Dec 15 1
14 24362713 Checkpoint kinase inhibitor AZD7762 overcomes cisplatin resistance in clear cell carcinoma of the ovary. 2014 Jan 1
15 24415413 Development of breast tumors in CHEK2, NBN/NBS1 and BLM mutation carriers does not commonly involve somatic inactivation of the wild-type allele. 2014 Feb 1
16 24480460 Aurora-A controls cancer cell radio- and chemoresistance via ATM/Chk2-mediated DNA repair networks. 2014 May 1
17 24657486 Checkpoint kinase 2 (Chk2) supports sensitivity to platinum-based treatment in high grade serous ovarian cancer. 2014 Jun 2
18 24853623 Co-abrogation of Chk1 and Chk2 by potent oncolytic adenovirus potentiates the antitumor efficacy of cisplatin or irradiation. 2014 May 1
19 25006835 Comparison of Intracellular Stress Response of NCI-H526 Small Cell Lung Cancer (SCLC) Cells to Platinum(II) Cisplatin and Platinum(IV) Oxoplatin. 2014 Jul 8 1
20 23940574 Regulators of global genome repair do not respond to DNA damaging therapy but correlate with survival in melanoma. 2013 1
21 24113180 A novel role for the anti-senescence factor TBX2 in DNA repair and cisplatin resistance. 2013 Oct 10 1
22 21592546 The impact of S- and G2-checkpoint response on the fidelity of G1-arrest by cisplatin and its comparison to a non-cross-resistant platinum(IV) analog. 2011 Aug 1
23 22312557 The Role of Wild-Type p53 in Cisplatin-Induced Chk2 Phosphorylation and the Inhibition of Platinum Resistance with a Chk2 Inhibitor. 2011 5
24 19889954 Inhibitors of histone deacetylases suppress cisplatin-induced p53 activation and apoptosis in renal tubular cells. 2010 Feb 1
25 20526748 Switching p53-dependent growth arrest to apoptosis via the inhibition of DNA damage-activated kinases. 2010 Sep 1
26 20700484 NPRL2 sensitizes human non-small cell lung cancer (NSCLC) cells to cisplatin treatment by regulating key components in the DNA repair pathway. 2010 Aug 5 2
27 20846399 Cisplatin sensitivity of testis tumour cells is due to deficiency in interstrand-crosslink repair and low ERCC1-XPF expression. 2010 Sep 16 1
28 18647348 Characterization of the role of a trimeric protein phosphatase complex in recovery from cisplatin-induced versus noncrosslinking DNA damage. 2008 Aug 1
29 18762365 Insulin-like growth factor-1 attenuates cisplatin-induced gammaH2AX formation and DNA double-strand breaks repair pathway in non-small cell lung cancer. 2008 Dec 18 1
30 16596250 Protein phosphatase 2A interacts with Chk2 and regulates phosphorylation at Thr-68 after cisplatin treatment of human ovarian cancer cells. 2006 May 4
31 15694385 Inducible degradation of checkpoint kinase 2 links to cisplatin-induced resistance in ovarian cancer cells. 2005 Mar 11 6