| 1 |
28886131 | Histone deacetylase regulates insulin signaling via two pathways in pancreatic β cells. | 2017 |
2 |
| 2 |
26846849 | Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase. | 2016 Apr 15 |
1 |
| 3 |
26976654 | Effect of dehydroepiandrosterone (DHEA) on Akt and protein kinase C zeta (PKCζ) phosphorylation in different tissues of C57BL6, insulin receptor substrate (IRS)1(-/-), and IRS2(-/-) male mice fed a high-fat diet. | 2016 May |
1 |
| 4 |
27330190 | The adaptor protein insulin receptor substrate 2 inhibits alternative macrophage activation and allergic lung inflammation. | 2016 Jun 21 |
2 |
| 5 |
23275337 | Selective serotonin reuptake inhibitors (SSRIs) inhibit insulin secretion and action in pancreatic β cells. | 2013 Feb 22 |
1 |
| 6 |
22128176 | Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice. | 2012 Jan 20 |
1 |
| 7 |
20360640 | [Molecular mechanism of SH2B1 in regulating JAK2/IRS2 during obesity development]. | 2010 Mar |
1 |
| 8 |
20547979 | Elimination of negative feedback control mechanisms along the insulin signaling pathway improves beta-cell function under stress. | 2010 Sep |
1 |
| 9 |
19542202 | SH2B1 enhances insulin sensitivity by both stimulating the insulin receptor and inhibiting tyrosine dephosphorylation of insulin receptor substrate proteins. | 2009 Sep |
2 |
| 10 |
19596788 | The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis. | 2009 Sep |
1 |
| 11 |
17513737 | Type 2 diabetes impairs insulin receptor substrate-2-mediated phosphatidylinositol 3-kinase activity in primary macrophages to induce a state of cytokine resistance to IL-4 in association with overexpression of suppressor of cytokine signaling-3. | 2007 Jun 1 |
1 |
| 12 |
15494611 | Stearoyl-CoA desaturase 1 deficiency increases insulin signaling and glycogen accumulation in brown adipose tissue. | 2005 Feb |
1 |
| 13 |
15821749 | Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action. | 2005 May |
1 |
| 14 |
15975995 | Roles of insulin receptor substrates in insulin-induced stimulation of renal proximal bicarbonate absorption. | 2005 Aug |
1 |
| 15 |
14693698 | Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice. | 2004 Jan |
1 |
| 16 |
14978080 | Transgenic expression of insulin receptor substrate 2 in murine B cells alters the cell density-dependence of IgE production in vitro and enhances IgE production in vivo. | 2004 Mar 1 |
1 |
| 17 |
15181014 | Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling. | 2004 Aug 13 |
1 |
| 18 |
15314154 | Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance. | 2004 Sep |
1 |
| 19 |
12706299 | Early intracellular events induced by in vivo leptin treatment in mouse skeletal muscle. | 2003 Mar 28 |
1 |
| 20 |
12810554 | Cytokine-hormone interactions: tumor necrosis factor alpha impairs biologic activity and downstream activation signals of the insulin-like growth factor I receptor in myoblasts. | 2003 Jul |
2 |
| 21 |
11812758 | Insulin signaling after exercise in insulin receptor substrate-2-deficient mice. | 2002 Feb |
4 |
| 22 |
11147812 | IRS-1 and IRS-2 are recruited by TrkA receptor and oncogenic TRK-T1. | 2001 Jan |
2 |
| 23 |
11259577 | Association of insulin receptor substrate 1 (IRS-1) y895 with Grb-2 mediates the insulin signaling involved in IRS-1-deficient brown adipocyte mitogenesis. | 2001 Apr |
1 |
| 24 |
11305324 | Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation. | 2001 Mar |
1 |
| 25 |
10202031 | IL-3 and IL-4 activate cyclic nucleotide phosphodiesterases 3 (PDE3) and 4 (PDE4) by different mechanisms in FDCP2 myeloid cells. | 1999 Apr 15 |
3 |
| 26 |
10207032 | Mutation of tyrosine 960 within the insulin receptor juxtamembrane domain impairs glucose transport but does not inhibit ligand-mediated phosphorylation of insulin receptor substrate-2 in 3T3-L1 adipocytes. | 1999 Apr 23 |
1 |
| 27 |
10449788 | A new mechanism of neurodegeneration: a proinflammatory cytokine inhibits receptor signaling by a survival peptide. | 1999 Aug 17 |
1 |
| 28 |
10517679 | Differential modulation of the tyrosine phosphorylation state of the insulin receptor by IRS (insulin receptor subunit) proteins. | 1999 Oct |
1 |
| 29 |
10535444 | Insulin signaling in insulin receptor substrate (IRS)-1-deficient brown adipocytes: requirement of IRS-1 for lipid synthesis. | 1999 Nov |
1 |
| 30 |
9519710 | Possibility of distinct insulin-signaling pathways beyond phosphatidylinositol 3-kinase-mediating glucose transport and lipogenesis. | 1998 Feb |
1 |
| 31 |
9565625 | Insulin-like growth factor-1 (IGF-1) receptor-insulin receptor substrate complexes in the uterus. Altered signaling response to estradiol in the IGF-1(m/m) mouse. | 1998 May 8 |
1 |
| 32 |
9624169 | Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1, -2, and -3, their association with p85 phosphatidylinositol 3-kinase (PI3-kinase), and concomitantly PI3-kinase activation via JAK2 kinase. | 1998 Jun 19 |
2 |
| 33 |
9813005 | IRS pleckstrin homology domains bind to acidic motifs in proteins. | 1998 Nov 20 |
1 |
| 34 |
8995447 | Insulin receptor substrate-2 is the major 170-kDa protein phosphorylated on tyrosine in response to cytokines in murine lymphohemopoietic cells. | 1997 Jan 10 |
4 |
| 35 |
9013772 | The IRS-2 gene on murine chromosome 8 encodes a unique signaling adapter for insulin and cytokine action. | 1997 Feb |
1 |
| 36 |
9325314 | Role of insulin receptor substrate-1 and pp60 in the regulation of insulin-induced glucose transport and GLUT4 translocation in primary adipocytes. | 1997 Oct 10 |
1 |
| 37 |
9633824 | IGF-I receptor protection from apoptosis in cells lacking the IRS proteins. | 1997 |
1 |
| 38 |
8649419 | Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice. | 1996 Jun |
1 |
| 39 |
8894493 | Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1 and identification of insulin receptor substrate-2. | 1996 Sep |
1 |
| 40 |
8954948 | Interleukin-4 activates two distinct pathways of phosphatidylinositol-3 kinase in the same cells. | 1996 Dec 13 |
2 |
| 41 |
7534300 | Identification of a 190-kDa protein as a novel substrate for the insulin receptor kinase functionally similar to insulin receptor substrate-1. | 1995 Mar 17 |
1 |
| 42 |
7675087 | Role of IRS-2 in insulin and cytokine signalling. | 1995 Sep 14 |
1 |
| 43 |
7526222 | Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. | 1994 Nov 10 |
1 |