Cyclic AMP

phosphodiesterase 10A ; Mus musculus







23 Article(s)
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Pub. Year
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1 34735672 Phosphodiesterase 10A Is a Critical Target for Neuroprotection in a Mouse Model of Ischemic Stroke. 2022 Jan 2
2 32378029 Phosphodiesterase 10A Inhibition Leads to Brain Region-Specific Recovery Based on Stroke Type. 2021 Apr 2
3 33907201 Transcriptional signatures in prefrontal cortex confer vulnerability versus resilience to food and cocaine addiction-like behavior. 2021 Apr 27 1
4 34117108 Phosphodiesterase 10A Is a Key Mediator of Lung Inflammation. 2021 Jun 15 2
5 34399440 Pivotal role of phosphodiesterase 10A in the integration of dopamine signals in mice striatal D1 and D2 medium-sized spiny neurones. 2021 Dec 3
6 34735298 Abstract MP265: The Role Of Phosphodiesterase 10a In Tumor Growth And Doxorubicin-induced Cardiotoxicity. 2021 Sep 3 2
7 30354987 RNA-Sequencing Analysis Revealed a Distinct Motor Cortex Transcriptome in Spontaneously Recovered Mice After Stroke. 2018 Sep 3
8 27811172 TAK-063, a Novel Phosphodiesterase 10A Inhibitor, Protects from Striatal Neurodegeneration and Ameliorates Behavioral Deficits in the R6/2 Mouse Model of Huntington's Disease. 2017 Jan 6
9 27896836 Radiosynthesis and biological evaluation of the new PDE10A radioligand [18 F]AQ28A. 2017 Jan 1
10 28115486 Phosphodiesterase-10A Inverse Changes in Striatopallidal and Striatoentopeduncular Pathways of a Transgenic Mouse Model of DYT1 Dystonia. 2017 Feb 22 16
11 26522433 Biochemical and behavioral effects of PDE10A inhibitors: Relationship to target site occupancy. 2016 Mar 3
12 25451212 Characterization of the binding properties of T-773 as a PET radioligand for phosphodiesterase 10A. 2015 Feb 1
13 25762721 Phosphodiesterase 10A Is Tethered to a Synaptic Signaling Complex in Striatum. 2015 May 8 5
14 25855188 Facilitation of corticostriatal transmission following pharmacological inhibition of striatal phosphodiesterase 10A: role of nitric oxide-soluble guanylyl cyclase-cGMP signaling pathways. 2015 Apr 8 1
15 26465004 Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32 2015 Jul-Aug 4
16 24698799 Genetic deletion of PDE10A selectively impairs incentive salience attribution and decreases medium spiny neuron excitability. 2014 Jul 15 2
17 23576401 PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a Huntington's disease mouse model. 2013 Aug 2
18 21130175 Impaired appetitively as well as aversively motivated behaviors and learning in PDE10A-deficient mice suggest a role for striatal signaling in evaluative salience attribution. 2011 Mar 2
19 19765598 Alterations in gene regulation following inhibition of the striatum-enriched phosphodiesterase, PDE10A. 2010 Feb 1
20 18088367 Increased social interaction in mice deficient of the striatal medium spiny neuron-specific phosphodiesterase 10A2. 2008 Apr 4
21 18923023 Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum. 2008 Oct 15 2
22 12904862 Cyclic nucleotide phosphodiesterases in pancreatic islets. 2003 Sep 1
23 10359840 Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A. 1999 Jun 8 4