| 1 |
33582554 | Coordinated action of microsomal prostaglandin E synthase-1 and prostacyclin synthase on contact hypersensitivity. | 2021 Mar 26 |
1 |
| 2 |
33788722 | Gene Deletion of Microsomal Prostaglandin E Synthase-1 Suppresses Chemically Induced Skin Carcinogenesis. | 2021 Mar |
2 |
| 3 |
32317963 | Pharmacological Characterization of the Microsomal Prostaglandin E2 Synthase-1 Inhibitor AF3485 In Vitro and In Vivo. | 2020 |
1 |
| 4 |
33255269 | A Representative GIIA Phospholipase A2 Activates Preadipocytes to Produce Inflammatory Mediators Implicated in Obesity Development. | 2020 Nov 24 |
1 |
| 5 |
30508550 | Central neuroimmune activity and depressive-like behavior in response to repeated maternal separation and injection of LPS. | 2019 Feb 1 |
1 |
| 6 |
29456107 | Design, synthesis, and discovery of 5-((1,3-diphenyl-1H-pyrazol-4-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones and related derivatives as novel inhibitors of mPGES-1. | 2018 Mar 1 |
2 |
| 7 |
30463256 | Endothelial Microsomal Prostaglandin E Synthetase-1 Upregulates Vascularity and Endothelial Interleukin-1β in Deteriorative Progression of Experimental Autoimmune Encephalomyelitis. | 2018 Nov 19 |
1 |
| 8 |
27464306 | Anti-inflammatory and analgesic activity of carnosol and carnosic acid in vivo and in vitro and in silico analysis of their target interactions. | 2017 Jun |
1 |
| 9 |
27570080 | Transcriptional Regulation of mPGES1 in Cancer: An Alternative Approach to Drug Discovery? | 2017 |
1 |
| 10 |
28240894 | Evaluation of Dual 5-Lipoxygenase/Microsomal Prostaglandin E2 Synthase-1 Inhibitory Effect of Natural and Synthetic Acronychia-Type Isoprenylated Acetophenones. | 2017 Mar 24 |
1 |
| 11 |
28484935 | Computational models for the classification of mPGES-1 inhibitors with fingerprint descriptors. | 2017 Aug |
1 |
| 12 |
28627961 | Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review. | 2017 Sep |
1 |
| 13 |
29226622 | PDE4 inhibitor rolipram inhibits the expression of microsomal prostaglandin E synthase-1 by a mechanism dependent on MAP kinase phosphatase-1. | 2017 Dec |
2 |
| 14 |
29257087 | Microsomal Prostaglandin E Synthase-1 Facilitates an Intercellular Interaction between CD4⁺ T Cells through IL-1β Autocrine Function in Experimental Autoimmune Encephalomyelitis. | 2017 Dec 19 |
1 |
| 15 |
26653180 | Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors. | 2016 Jan 14 |
1 |
| 16 |
26673392 | Identification of novel membrane-associated prostaglandin E synthase-1 (mPGES-1) inhibitors with anti-influenza activities in vitro. | 2016 Jan 22 |
1 |
| 17 |
26755582 | A dynamic Asp-Arg interaction is essential for catalysis in microsomal prostaglandin E2 synthase. | 2016 Jan 26 |
1 |
| 18 |
26987561 | Aminothiazoles inhibit RANKL- and LPS-mediated osteoclastogenesis and PGE2 production in RAW 264.7 cells. | 2016 Jun |
1 |
| 19 |
27059285 | Increased lethality and defective pulmonary clearance of Streptococcus pneumoniae in microsomal prostaglandin E synthase-1-knockout mice. | 2016 Jun 1 |
1 |
| 20 |
27440004 | Cardiovascular Consequences of Prostanoid I Receptor Deletion in Microsomal Prostaglandin E Synthase-1-Deficient Hyperlipidemic Mice. | 2016 Jul 26 |
1 |
| 21 |
27758933 | Deletion of mPGES-1 affects platelet functions in mice. | 2016 Dec 1 |
1 |
| 22 |
25726376 | Functional consequences of knocking down porcine prostaglandin synthases in SK-6 swine kidney cell line. | 2015 Mar |
1 |
| 23 |
25961169 | Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics. | 2015 Jun 11 |
1 |
| 24 |
25968070 | Close teamwork between Nrf2 and peroxiredoxins 1 and 6 for the regulation of prostaglandin D2 and E2 production in macrophages in acute inflammation. | 2015 Nov |
1 |
| 25 |
26002457 | Inflammatory Pathways in Knee Osteoarthritis: Potential Targets for Treatment. | 2015 |
2 |
| 26 |
26611322 | Genetic-deletion of Cyclooxygenase-2 Downstream Prostacyclin Synthase Suppresses Inflammatory Reactions but Facilitates Carcinogenesis, unlike Deletion of Microsomal Prostaglandin E Synthase-1. | 2015 Nov 27 |
1 |
| 27 |
24794772 | Exploration of the dihydropyrimidine scaffold for the development of new potential anti-inflammatory agents blocking prostaglandin E₂ synthase-1 enzyme (mPGES-1). | 2014 Jun 10 |
1 |
| 28 |
25015655 | A mouse strain less responsive to dioxin-induced prostaglandin E2 synthesis is resistant to the onset of neonatal hydronephrosis. | 2014 Oct |
2 |
| 29 |
25019142 | Inhibitors of microsomal prostaglandin E2 synthase-1 enzyme as emerging anti-inflammatory candidates. | 2014 Jul |
1 |
| 30 |
25176110 | Peptidylarginine deiminase from Porphyromonas gingivalis contributes to infection of gingival fibroblasts and induction of prostaglandin E2 -signaling pathway. | 2014 Dec |
1 |
| 31 |
25260492 | Development of 2-aryl substituted quinazolin-4(3H)-one, pyrido[4,3-d]pyrimidin-4(3H)-one and pyrido[2,3-d]pyrimidin-4(3H)-one derivatives as microsomal prostaglandin E(2) synthase-1 inhibitors. | 2014 Oct 15 |
1 |
| 32 |
23260349 | Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation. | 2013 Feb 15 |
1 |
| 33 |
23266396 | Microsomal prostaglandin E synthase-1 aggravates inflammation and demyelination in a mouse model of multiple sclerosis. | 2013 Feb |
1 |
| 34 |
23527738 | Discovery of highly potent microsomal prostaglandin e2 synthase 1 inhibitors using the active conformation structural model and virtual screen. | 2013 Apr 25 |
1 |
| 35 |
24035605 | Identification of multiple and distinct defects in prostaglandin biosynthetic pathways in eutopic and ectopic endometrium of women with endometriosis. | 2013 Dec |
1 |
| 36 |
24045148 | Characterization of a human and murine mPGES-1 inhibitor and comparison to mPGES-1 genetic deletion in mouse models of inflammation. | 2013 Dec |
1 |
| 37 |
24101387 | The effect of reactive oxygen species on the synthesis of prostanoids from arachidonic acid. | 2013 Aug |
1 |
| 38 |
21931968 | Identification of a novel class of anti-inflammatory compounds with anti-tumor activity in colorectal and lung cancers. | 2012 Oct |
1 |
| 39 |
22209272 | Pyrrole alkanoic acid derivatives as nuisance inhibitors of microsomal prostaglandin E2 synthase-1. | 2012 Feb |
1 |
| 40 |
22214188 | Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia. | 2012 Jan 3 |
1 |
| 41 |
22505934 | Prostaglandins in cancer cell adhesion, migration, and invasion. | 2012 |
2 |
| 42 |
22633646 | Immunohistochemical expression of COX-2, mPGES and EP2 receptor in normal and reactive canine bone and in canine osteosarcoma. | 2012 Aug-Oct |
1 |
| 43 |
21239760 | Valproic acid suppresses interleukin-1ß-induced microsomal prostaglandin E2 synthase-1 expression in chondrocytes through upregulation of NAB1. | 2011 Mar |
1 |
| 44 |
21266028 | mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis. | 2011 |
1 |
| 45 |
21277633 | IL-4 and IL-13 suppress prostaglandins production in human follicular dendritic cells by repressing COX-2 and mPGES-1 expression through JAK1 and STAT6. | 2011 Mar |
1 |
| 46 |
21282500 | Microsomal prostaglandin e2 synthase-1 modulates the response to vascular injury. | 2011 Feb 15 |
1 |
| 47 |
21310608 | A novel class of dual mPGES-1/5-LO inhibitors based on the α-naphthyl pirinixic acid scaffold. | 2011 Mar 1 |
1 |
| 48 |
21591611 | Discovery and biological evaluation of a novel class of dual microsomal prostaglandin E2 synthase-1/5-lipoxygenase inhibitors based on 2-[(4,6-diphenethoxypyrimidin-2-yl)thio]hexanoic acid. | 2011 Jul 14 |
1 |
| 49 |
21797823 | Microsomal prostaglandin E synthase-1 exhibits one-third-of-the-sites reactivity. | 2011 Nov 15 |
1 |
| 50 |
21939657 | Ketogenic diet-induced peroxisome proliferator-activated receptor-γ activation decreases neuroinflammation in the mouse hippocampus after kainic acid-induced seizures. | 2011 Dec |
1 |