N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide

mixed lineage kinase domain like pseudokinase ; Homo sapiens







22 Article(s)
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1 31760070 Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease. 2020 Apr 2
2 31894265 Ophiopogonin D' induces RIPK1‑dependent necroptosis in androgen‑dependent LNCaP prostate cancer cells. 2020 Feb 2
3 32075957 Inhibition of keratinocyte necroptosis mediated by RIPK1/RIPK3/MLKL provides a protective effect against psoriatic inflammation. 2020 Feb 19 2
4 32196619 Necrosulfonamide (NSA) protects intervertebral disc degeneration via necroptosis and apoptosis inhibition. 2020 Mar 1
5 32297735 Dissecting Programmed Cell Death with Small Molecules. 2020 May 19 2
6 33318170 Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis. 2020 Dec 29 1
7 31129968 Receptor interacting protein kinase 3 promotes cisplatin-induced necroptosis in apoptosis-resistant HepG2/DDP cells. 2019 Sep 2
8 31132314 Decrease in fat de novo synthesis and chemokine ligand expression in non-alcoholic fatty liver disease caused by inhibition of mixed lineage kinase domain-like pseudokinase. 2019 Dec 1
9 31727943 Understanding allosteric interactions in hMLKL protein that modulate necroptosis and its inhibition. 2019 Nov 14 5
10 28088644 Tert-butyl hydroperoxide (t-BHP) induced apoptosis and necroptosis in endothelial cells: Roles of NOX4 and mitochondrion. 2017 Apr 1
11 28827318 MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis. 2017 Sep 5 2
12 28878015 Thioredoxin-1 actively maintains the pseudokinase MLKL in a reduced state to suppress disulfide bond-dependent MLKL polymer formation and necroptosis. 2017 Oct 20 2
13 28923396 Smac mimetics and type II interferon synergistically induce necroptosis in various cancer cell lines. 2017 Dec 1 1
14 29101355 Particles of different sizes and shapes induce neutrophil necroptosis followed by the release of neutrophil extracellular trap-like chromatin. 2017 Nov 3 2
15 26531064 PMA and crystal-induced neutrophil extracellular trap formation involves RIPK1-RIPK3-MLKL signaling. 2016 Jan 2
16 26817517 Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis. 2016 Jan 28 1
17 27756752 TSC2 Deficiency Unmasks a Novel Necrosis Pathway That Is Suppressed by the RIP1/RIP3/MLKL Signaling Cascade. 2016 Dec 15 1
18 25766324 Readthrough acetylcholinesterase (AChE-R) and regulated necrosis: pharmacological targets for the regulation of ovarian functions? 2015 Mar 12 1
19 26028172 Identification of a novel synergistic induction of cell death by Smac mimetic and HDAC inhibitors in acute myeloid leukemia cells. 2015 Sep 28 2
20 25593994 Necroptosis is associated with low procaspase-8 and active RIPK1 and -3 in human glioma cells. 2014 1
21 22265413 Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. 2012 Jan 20 2
22 22860037 Staurosporine induces necroptotic cell death under caspase-compromised conditions in U937 cells. 2012 1