| 1 |
32946962 | Orostachys japonicus ameliorates acetaminophen-induced acute liver injury in mice. | 2021 Jan 30 |
1 |
| 2 |
33127475 | Pregnane X receptor (PXR) protects against cisplatin-induced acute kidney injury in mice. | 2021 Mar 1 |
4 |
| 3 |
33387840 | Lipidomic profiling reveals triacylglycerol accumulation in the liver during pregnane X receptor activation-induced hepatomegaly. | 2021 Feb 20 |
1 |
| 4 |
31907988 | The xenobiotic sensing pregnane X receptor regulates tissue damage and inflammation triggered by C difficile toxins. | 2020 Feb |
4 |
| 5 |
31998607 | The 3'-untranslated region contributes to the pregnane X receptor (PXR) expression down-regulation by PXR ligands and up-regulation by glucocorticoids. | 2020 Jan |
1 |
| 6 |
33076328 | PXR Functionally Interacts with NF-κB and AP-1 to Downregulate the Inflammation-Induced Expression of Chemokine CXCL2 in Mice. | 2020 Oct 15 |
1 |
| 7 |
30442521 | Constitutive androstane receptor and pregnane X receptor cooperatively ameliorate DSS-induced colitis. | 2019 Feb |
2 |
| 8 |
30593543 | Regulation of Hepatic Long Noncoding RNAs by Pregnane X Receptor and Constitutive Androstane Receptor Agonists in Mouse Liver. | 2019 Mar |
1 |
| 9 |
31374856 | Gene Expression Profiling Reveals that PXR Activation Inhibits Hepatic PPARα Activity and Decreases FGF21 Secretion in Male C57Bl6/J Mice. | 2019 Aug 1 |
2 |
| 10 |
31388680 | Epigenetic Memory Is Involved in the Persistent Alterations of Drug-Processing Genes in Adult Mice due to PCN-Activated PXR during Early Life. | 2019 Aug 6 |
4 |
| 11 |
31723190 | Nutritional status modifies pregnane X receptor regulated transcriptome. | 2019 Nov 13 |
3 |
| 12 |
29309761 | Activation of nuclear receptor PXR impairs glucose tolerance and dysregulates GLUT2 expression and subcellular localization in liver. | 2018 Feb |
3 |
| 13 |
29863087 | Effect of Pregnenolone 16α-Carbonitrile on the Expression of P-Glycoprotein in the Intestine, Brain and Liver of Mice. | 2018 |
2 |
| 14 |
28237809 | Pregnenolone 16α-carbonitrile ameliorates concanavalin A-induced liver injury in mice independent of the nuclear receptor PXR activation. | 2017 Apr 5 |
5 |
| 15 |
28428138 | Pregnane X receptor regulates the AhR/Cyp1A1 pathway and protects liver cells from benzo-[α]-pyrene-induced DNA damage. | 2017 Jun 5 |
6 |
| 16 |
26574435 | PXR stimulates growth factor-mediated hepatocyte proliferation by cross-talk with the FOXO transcription factor. | 2016 Feb 1 |
2 |
| 17 |
27113289 | RNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome. | 2016 Sep |
1 |
| 18 |
27440420 | Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation. | 2016 Oct |
2 |
| 19 |
24486481 | Pregnane X receptor agonists enhance intestinal epithelial wound healing and repair of the intestinal barrier following the induction of experimental colitis. | 2014 May 13 |
3 |
| 20 |
23532932 | Bioimaging real-time PXR-dependent mdr1a gene regulation in mdr1a.fLUC reporter mice. | 2013 Jun |
2 |
| 21 |
24121122 | Functional characterization of a full length pregnane X receptor, expression in vivo, and identification of PXR alleles, in zebrafish (Danio rerio). | 2013 Oct 15 |
1 |
| 22 |
22687401 | Establishment of a stable human cell line, HPL-A3, for use in reporter gene assays of cytochrome P450 3A inducers. | 2012 |
1 |
| 23 |
22723881 | Activation of pregnane X receptor by pregnenolone 16 α-carbonitrile prevents high-fat diet-induced obesity in AKR/J mice. | 2012 |
3 |
| 24 |
18981260 | Nuclear xenobiotic receptor pregnane X receptor locks corepressor silencing mediator for retinoid and thyroid hormone receptors (SMRT) onto the CYP24A1 promoter to attenuate vitamin D3 activation. | 2009 Feb |
1 |
| 25 |
19141872 | Metabolomics reveals a novel vitamin E metabolite and attenuated vitamin E metabolism upon PXR activation. | 2009 May |
3 |
| 26 |
19144771 | Induction of mouse UDP-glucuronosyltransferase mRNA expression in liver and intestine by activators of aryl-hydrocarbon receptor, constitutive androstane receptor, pregnane X receptor, peroxisome proliferator-activated receptor alpha, and nuclear factor erythroid 2-related factor 2. | 2009 Apr |
1 |
| 27 |
19183106 | Activation of the nuclear receptor PXR decreases plasma LDL-cholesterol levels and induces hepatic steatosis in LDL receptor knockout mice. | 2009 Jan-Feb |
2 |
| 28 |
19359405 | Regulation of tissue-specific carboxylesterase expression by pregnane x receptor and constitutive androstane receptor. | 2009 Jul |
1 |
| 29 |
19432992 | Low affinity glucocorticoid binding site ligands as potential anti-fibrogenics. | 2009 May 11 |
5 |
| 30 |
19436068 | Activation of PXR induces hypercholesterolemia in wild-type and accelerates atherosclerosis in apoE deficient mice. | 2009 Oct |
4 |
| 31 |
19542321 | The aldo-keto reductase Akr1b7 gene is a common transcriptional target of xenobiotic receptors pregnane X receptor and constitutive androstane receptor. | 2009 Sep |
3 |
| 32 |
18448072 | PPARalpha gene expression is up-regulated by LXR and PXR activators in the small intestine. | 2008 Jul 11 |
2 |
| 33 |
17020958 | Gender dictates the nuclear receptor-mediated regulation of CYP3A44. | 2007 Jan |
5 |
| 34 |
17093002 | The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A. | 2007 Feb |
2 |
| 35 |
17170021 | Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-kappaB target gene expression. | 2007 Apr |
2 |
| 36 |
17267396 | Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liver. | 2007 Mar 30 |
8 |
| 37 |
17435798 | Hepatoprotective role of PXR activation and MRP3 in cholic acid-induced cholestasis. | 2007 Jun |
2 |
| 38 |
17635106 | Human nuclear pregnane X receptor cross-talk with CREB to repress cAMP activation of the glucose-6-phosphatase gene. | 2007 Nov 1 |
4 |
| 39 |
16195250 | Orphan nuclear receptor pregnane X receptor sensitizes oxidative stress responses in transgenic mice and cancerous cells. | 2006 Feb |
1 |
| 40 |
16749864 | Activation of human CYP2C9 promoter and regulation by CAR and PXR in mouse liver. | 2006 May-Jun |
2 |
| 41 |
16928788 | Regulation of mRNA expression of xenobiotic transporters by the pregnane x receptor in mouse liver, kidney, and intestine. | 2006 Nov |
2 |
| 42 |
15595924 | Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms. | 2005 May 1 |
6 |
| 43 |
15919853 | Regulation of mouse organic anion-transporting polypeptides (Oatps) in liver by prototypical microsomal enzyme inducers that activate distinct transcription factor pathways. | 2005 Sep |
3 |
| 44 |
14770174 | CAR/PXR provide directives for Cyp3a41 gene regulation differently from Cyp3a11. | 2004 |
1 |
| 45 |
15340055 | Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes. | 2004 Sep |
1 |
| 46 |
15456926 | Enhanced acetaminophen toxicity by activation of the pregnane X receptor. | 2004 Dec |
5 |
| 47 |
12632254 | Expression of cytochromes P450 3A in mouse lung: effects of dexamethasone and pregnenolone 16alpha-carbonitrile. | 2003 Mar |
2 |
| 48 |
12695359 | Induction of cytochrome P450 3A by paclitaxel in mice: pivotal role of the nuclear xenobiotic receptor, pregnane X receptor. | 2003 May |
1 |
| 49 |
12814968 | Nuclear receptor, pregname X receptor, is required for induction of UDP-glucuronosyltranferases in mouse liver by pregnenolone-16 alpha-carbonitrile. | 2003 Jul |
5 |
| 50 |
10935643 | Humanized xenobiotic response in mice expressing nuclear receptor SXR. | 2000 Jul 27 |
1 |