| 1 |
34982556 | Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site. | 2022 Feb 10 |
2 |
| 2 |
33802888 | Synthesis and Structure-Activity Relationships of Aristoyagonine Derivatives as Brd4 Bromodomain Inhibitors with X-ray Co-Crystal Research. | 2021 Mar 17 |
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| 3 |
33820450 | Discovery of the natural product 3',4',7,8-tetrahydroxyflavone as a novel and potent selective BRD4 bromodomain 2 inhibitor. | 2021 Dec |
4 |
| 4 |
34039605 | BRD4 methylation by the methyltransferase SETD6 regulates selective transcription to control mRNA translation. | 2021 May |
2 |
| 5 |
34519605 | Inhibition of BRD4 Suppresses the Growth of Esophageal Squamous Cell Carcinoma. | 2021 Nov |
2 |
| 6 |
32324495 | BET Epigenetic Reader Proteins in Cardiovascular Transcriptional Programs. | 2020 Apr 24 |
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| 7 |
32499570 | BRD4 promotes metastatic potential in oral squamous cell carcinoma through the epigenetic regulation of the MMP2 gene. | 2020 Aug |
3 |
| 8 |
32522824 | p300-Mediated Acetylation of Histone Demethylase JMJD1A Prevents Its Degradation by Ubiquitin Ligase STUB1 and Enhances Its Activity in Prostate Cancer. | 2020 Aug 1 |
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| 9 |
30565859 | Structural and thermodynamic characterization of the binding of isoliquiritigenin to the first bromodomain of BRD4. | 2019 May |
2 |
| 10 |
31266503 | BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity. | 2019 Jul 2 |
1 |
| 11 |
31311807 | BRD4 Promotes Gastric Cancer Progression and Metastasis through Acetylation-Dependent Stabilization of Snail. | 2019 Oct 1 |
1 |
| 12 |
29440272 | Nitric oxide antagonism to glioblastoma photodynamic therapy and mitigation thereof by BET bromodomain inhibitor JQ1. | 2018 Apr 6 |
1 |
| 13 |
29996811 | BET Bromodomain inhibition promotes De-repression of TXNIP and activation of ASK1-MAPK pathway in acute myeloid leukemia. | 2018 Jul 11 |
1 |
| 14 |
30012592 | Spatially constrained tandem bromodomain inhibition bolsters sustained repression of BRD4 transcriptional activity for TNBC cell growth. | 2018 Jul 31 |
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| 15 |
30253095 | Molecular Basis for the N-Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase-Bromodomain Inhibitor. | 2018 Oct 25 |
4 |
| 16 |
30272279 | Inhibition of BRD4 suppresses tumor growth in prostate cancer via the enhancement of FOXO1 expression. | 2018 Dec |
2 |
| 17 |
27494802 | Molecular docking and dynamics simulation study of flavonoids as BET bromodomain inhibitors. | 2017 Aug |
2 |
| 18 |
28347667 | Discovery of novel BRD4 inhibitors by high-throughput screening, crystallography, and cell-based assays. | 2017 May 1 |
1 |
| 19 |
28549889 | Synthesis and evaluation of novel dual BRD4/HDAC inhibitors. | 2017 Jul 15 |
1 |
| 20 |
28626565 | Site-specific azide-acetyllysine photochemistry on epigenetic readers for interactome profiling. | 2017 Jun 1 |
2 |
| 21 |
28881723 | Association of high microvessel αvβ3 and low PTEN with poor outcome in stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126. | 2017 Aug 8 |
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| 22 |
25946208 | A Genetically Encoded FRET Probe to Detect Intranucleosomal Histone H3K9 or H3K14 Acetylation Using BRD4, a BET Family Member. | 2016 Mar 18 |
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| 23 |
27007123 | The Brd4 acetyllysine-binding protein is involved in activation of polyomavirus JC. | 2016 Oct |
1 |
| 24 |
27238211 | NMR-based platform for fragment-based lead discovery used in screening BRD4-targeted compounds. | 2016 Jul |
3 |
| 25 |
27264992 | Isoxazole-Derived Amino Acids are Bromodomain-Binding Acetyl-Lysine Mimics: Incorporation into Histone H4 Peptides and Histone H3. | 2016 Jul 11 |
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| 26 |
27290915 | An Overview on Small Molecule Inhibitors of BRD4. | 2016 |
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| 27 |
25603177 | BRD4 inhibitor inhibits colorectal cancer growth and metastasis. | 2015 Jan 16 |
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| 28 |
25788266 | H4K12ac is regulated by estrogen receptor-alpha and is associated with BRD4 function and inducible transcription. | 2015 Mar 30 |
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| 29 |
25941994 | Disruption of BRD4 at H3K27Ac-enriched enhancer region correlates with decreased c-Myc expression in Merkel cell carcinoma. | 2015 |
2 |
| 30 |
24435446 | Highly active combination of BRD4 antagonist and histone deacetylase inhibitor against human acute myelogenous leukemia cells. | 2014 May |
1 |
| 31 |
24733848 | Bromodomain and extraterminal proteins suppress NF-E2-related factor 2-mediated antioxidant gene expression. | 2014 May 15 |
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| 32 |
24939842 | Histone cross-talk connects protein phosphatase 1α (PP1α) and histone deacetylase (HDAC) pathways to regulate the functional transition of bromodomain-containing 4 (BRD4) for inducible gene expression. | 2014 Aug 15 |
2 |
| 33 |
25097667 | Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching. | 2014 |
1 |
| 34 |
24100334 | Different orientations of low-molecular-weight fragments in the binding pocket of a BRD4 bromodomain. | 2013 Oct |
1 |
| 35 |
23086925 | Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. | 2012 Dec 14 |
1 |
| 36 |
21983563 | Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation. | 2011 Oct 9 |
3 |
| 37 |
20715035 | Interaction of propionylated and butyrylated histone H3 lysine marks with Brd4 bromodomains. | 2010 Sep 10 |
1 |
| 38 |
19103749 | Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA. | 2009 Mar |
4 |
| 39 |
20495683 | Brd4 engagement from chromatin targeting to transcriptional regulation: selective contact with acetylated histone H3 and H4. | 2009 |
2 |
| 40 |
16339075 | Brd4 is required for recovery from antimicrotubule drug-induced mitotic arrest: preservation of acetylated chromatin. | 2006 Feb |
1 |
| 41 |
9048422 | Self-assembly of cyclic peptides on a dendrimer: multiple cyclic antigen peptides. | 1996 Nov-Dec |
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