Cysteine

⇄

CF transmembrane conductance regulator ; Homo sapiens







40 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
1 29524019 Aberrant GSH reductase and NOX activities concur with defective CFTR to pro-oxidative imbalance in cystic fibrosis airways. 2018 Apr 1
2 27585394 The Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Ivacaftor Augments Mucociliary Clearance Abrogating Cystic Fibrosis Transmembrane Conductance Regulator Inhibition by Cigarette Smoke. 2017 Jan 1
3 26659082 Cytoplasmic pathway followed by chloride ions to enter the CFTR channel pore. 2016 May 1
4 27114613 Spatial positioning of CFTR's pore-lining residues affirms an asymmetrical contribution of transmembrane segments to the anion permeation pathway. 2016 May 2
5 27175795 External Zn(2+) binding to cysteine-substituted cystic fibrosis transmembrane conductance regulator constructs regulates channel gating and curcumin potentiation. 2016 Jul 1
6 25825169 Cysteine accessibility probes timing and extent of NBD separation along the dimer interface in gating CFTR channels. 2015 Apr 1
7 26024338 The Fifth Transmembrane Segment of Cystic Fibrosis Transmembrane Conductance Regulator Contributes to Its Anion Permeation Pathway. 2015 Jun 23 1
8 24412276 The cystic fibrosis V232D mutation inhibits CFTR maturation by disrupting a hydrophobic pocket rather than formation of aberrant interhelical hydrogen bonds. 2014 Mar 1 1
9 25367045 Conformational changes opening and closing the CFTR chloride channel: insights from cysteine scanning mutagenesis. 2014 Dec 1
10 23442957 Cysteine scanning of CFTR's first transmembrane segment reveals its plausible roles in gating and permeation. 2013 Feb 19 4
11 22234285 Conformational change opening the CFTR chloride channel pore coupled to ATP-dependent gating. 2012 Mar 3
12 22303012 Alternating access to the transmembrane domain of the ATP-binding cassette protein cystic fibrosis transmembrane conductance regulator (ABCC7). 2012 Mar 23 2
13 21746847 Alignment of transmembrane regions in the cystic fibrosis transmembrane conductance regulator chloride channel pore. 2011 Aug 2
14 21796338 Functional arrangement of the 12th transmembrane region in the CFTR chloride channel pore based on functional investigation of a cysteine-less CFTR variant. 2011 Oct 5
15 21796426 Functional differences in pore properties between wild-type and cysteine-less forms of the CFTR chloride channel. 2011 Oct 7
16 22014307 Cystic fibrosis transmembrane conductance regulator: temperature-dependent cysteine reactivity suggests different stable conformers of the conduction pathway. 2011 Nov 29 3
17 22042986 Structural basis for the channel function of a degraded ABC transporter, CFTR (ABCC7). 2011 Nov 2
18 20675380 Changes in accessibility of cytoplasmic substances to the pore associated with activation of the cystic fibrosis transmembrane conductance regulator chloride channel. 2010 Oct 15 1
19 19114635 Mutations at the signature sequence of CFTR create a Cd(2+)-gated chloride channel. 2009 Jan 2
20 19381710 Novel residues lining the CFTR chloride channel pore identified by functional modification of introduced cysteines. 2009 Apr 1
21 19466983 Cysteine-independent inhibition of the CFTR chloride channel by the cysteine-reactive reagent sodium (2-sulphonatoethyl) methanethiosulphonate. 2009 Jul 5
22 17849169 A possible role for intracellular GSH in spontaneous reaction of a cysteine (T338C) engineered into the Cystic Fibrosis Transmembrane Conductance Regulator. 2008 Jun 1
23 18167343 State-dependent access of anions to the cystic fibrosis transmembrane conductance regulator chloride channel pore. 2008 Mar 7 2
24 17911111 Correctors promote maturation of cystic fibrosis transmembrane conductance regulator (CFTR)-processing mutants by binding to the protein. 2007 Nov 16 9
25 16236827 Mercury and zinc differentially inhibit shark and human CFTR orthologues: involvement of shark cysteine 102. 2006 Mar 1
26 16417523 The chemical chaperone CFcor-325 repairs folding defects in the transmembrane domains of CFTR-processing mutants. 2006 May 1 1
27 16436375 Variable reactivity of an engineered cysteine at position 338 in cystic fibrosis transmembrane conductance regulator reflects different chemical states of the thiol. 2006 Mar 24 1
28 16484308 The role of cystic fibrosis transmembrane conductance regulator phenylalanine 508 side chain in ion channel gating. 2006 Apr 15 1
29 16497707 Using a cysteine-less mutant to provide insight into the structure and mechanism of CFTR. 2006 Apr 15 1
30 15504728 Determination of the functional unit of the cystic fibrosis transmembrane conductance regulator chloride channel. One polypeptide forms one pore. 2005 Jan 7 1
31 15657297 Reversible silencing of CFTR chloride channels by glutathionylation. 2005 Feb 2
32 16227620 State-dependent chemical reactivity of an engineered cysteine reveals conformational changes in the outer vestibule of the cystic fibrosis transmembrane conductance regulator. 2005 Dec 23 2
33 15272010 The DeltaF508 mutation disrupts packing of the transmembrane segments of the cystic fibrosis transmembrane conductance regulator. 2004 Sep 17 1
34 15355964 Mutation of the aromatic amino acid interacting with adenine moiety of ATP to a polar residue alters the properties of multidrug resistance protein 1. 2004 Nov 19 1
35 11867445 Cysteine residues in the nucleotide binding domains regulate the conductance state of CFTR channels. 2002 Mar 2
36 11914543 Intracellular cysteines of the cystic fibrosis transmembrane conductance regulator (CFTR) modulate channel gating. 2002 2
37 11917520 Probing CFTR channel structure and function using the substituted-cysteine-accessibility method. 2002 1
38 12039948 Cysteine string protein interacts with and modulates the maturation of the cystic fibrosis transmembrane conductance regulator. 2002 Aug 9 1
39 11688981 Interdomain but not intermolecular interactions observed in CFTR channels. 2001 Nov 9 1
40 9325282 Covalent modification of the regulatory domain irreversibly stimulates cystic fibrosis transmembrane conductance regulator. 1997 Oct 10 1