Proline

microtubule associated protein tau ; Homo sapiens







80 Article(s)
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1 35007692 Association of α-1-Antichymotrypsin Expression with the Development of Conformational Changes of Tau Protein in Alzheimer's Disease Brain. 2022 Jan 8 1
2 35381286 In vitro characterization and molecular dynamics simulation reveal mechanism of 14-3-3ζ regulated phase separation of the tau protein. 2022 May 31 2
3 33452693 Interplay between tau and α-synuclein liquid-liquid phase separation. 2021 Jul 2
4 33459229 GSK-3 Inhibitors: A New Class of Drugs for Alzheimer's Disease Treatment. 2021 1
5 33663205 Uncovering the Effect of pS202/pT205/pS208 Triple Phosphorylations on the Conformational Features of the Key Fragment G192-T212 of Tau Protein. 2021 Mar 17 1
6 33680370 Role of Phosphorylation and Hyperphosphorylation of Tau in Its Interaction with βα Dimeric Tubulin Studied from a Bioinformatics Perspective. 2021 Jan-Mar 2
7 33794133 Interaction between the guanylate kinase domain of PSD-95 and the proline-rich region and microtubule binding repeats 2 and 3 of tau. 2021 Oct 1
8 34310938 Disease-associated mutations affect TIA1 phase separation and aggregation in a proline-dependent manner. 2021 Oct 1 1
9 34473990 Activity-dependent release of phosphorylated human tau from Drosophila neurons in primary culture. 2021 Oct 1
10 34559968 Probing the Internal Dynamics and Shape of Simple Peptides in Urea, Guanidinium Hydrochloride, and Proline Solutions with Time-Resolved Fluorescence Anisotropy and Atomistic Cosolvent Simulations. 2021 Oct 7 1
11 31698056 A peptide inhibitor of Tau-SH3 interactions ameliorates amyloid-β toxicity. 2020 Feb 2
12 32126198 Tau Reduction Prevents Key Features of Autism in Mouse Models. 2020 May 6 2
13 32997736 The proline-rich domain promotes Tau liquid-liquid phase separation in cells. 2020 Nov 2 1
14 33110983 Machine Learning for Discovery of GSK3β Inhibitors. 2020 Oct 20 1
15 33148293 Conformation-selective tau monoclonal antibodies inhibit tau pathology in primary neurons and a mouse model of Alzheimer's disease. 2020 Nov 4 2
16 33188775 Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease. 2020 Dec 10 1
17 33273615 Solid-state NMR investigation of the involvement of the P2 region in tau amyloid fibrils. 2020 Dec 3 2
18 31112821 Systematic profiling of SH3-mediated Tau-Partner interaction network in Alzheimer's disease by integrating in silico analysis and in vitro assay. 2019 Jul 4
19 31358628 In vitro 0N4R tau fibrils contain a monomorphic β-sheet core enclosed by dynamically heterogeneous fuzzy coat segments. 2019 Aug 13 1
20 31399291 A Possible Neurodegeneration Mechanism Triggered by Diabetes. 2019 Oct 1
21 31699899 Independent tubulin binding and polymerization by the proline-rich region of Tau is regulated by Tau's N-terminal domain. 2019 Dec 13 3
22 30318466 Structural Basis for Recognition of a Unique Epitope by a Human Anti-tau Antibody. 2018 Dec 4 2
23 28341999 Immunological memory to hyperphosphorylated tau in asymptomatic individuals. 2017 May 1
24 29051562 Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects. 2017 Oct 19 2
25 27193083 Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer's disease. 2016 May 18 2
26 25467137 Configuration-specific immunotherapy targeting cis pThr231-Pro232 tau for Alzheimer disease. 2015 Jan 15 3
27 25628064 The emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease. 2015 Apr 1
28 26502977 Analysis of in vivo turnover of tau in a mouse model of tauopathy. 2015 Oct 26 2
29 24559475 OGlcNAcylation and phosphorylation have opposing structural effects in tau: phosphothreonine induces particular conformational order. 2014 Mar 12 1
30 23362255 Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites. 2013 Mar 15 2
31 23979027 TOC1: characterization of a selective oligomeric tau antibody. 2013 1
32 22235112 γ-Aminobutyric acid type A (GABAA) receptor activation modulates tau phosphorylation. 2012 Feb 24 3
33 22464332 Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease. 2012 Mar 30 1
34 21056617 Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease. 2011 Jan 2
35 21489990 Early growth response 1 (Egr-1) regulates phosphorylation of microtubule-associated protein tau in mammalian brain. 2011 Jun 10 8
36 21514440 Tyrosine nitration within the proline-rich region of Tau in Alzheimer's disease. 2011 May 2
37 21910444 Structural impact of proline-directed pseudophosphorylation at AT8, AT100, and PHF1 epitopes on 441-residue tau. 2011 Oct 12 1
38 20160454 'Prion-like' propagation of mouse and human tau aggregates in an inducible mouse model of tauopathy. 2010 1
39 19074508 Alzheimer disease specific phosphoepitopes of Tau interfere with assembly of tubulin but not binding to microtubules. 2009 Apr 1
40 18199773 The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy. 2008 Jan 16 3
41 18725412 Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation. 2008 Nov 14 3
42 17908042 N-phenylamine derivatives as aggregation inhibitors in cell models of tauopathy. 2007 Sep 1
43 18220518 Inhibition of tau aggregation in cell models of tauopathy. 2007 Dec 3
44 16772869 Formation of phospho-SAPK/JNK granules in the hippocampus is an early event in Alzheimer disease. 2006 May 2
45 15615649 Tau and src family tyrosine kinases. 2005 Jan 3 2
46 16024764 Estradiol prevents neural tau hyperphosphorylation characteristic of Alzheimer's disease. 2005 Jun 2
47 16095818 DNA sequence variations in the prolyl isomerase Pin1 gene and Alzheimer's disease. 2005 Dec 2 1
48 14660656 Comparative vibrational spectroscopy of intracellular tau and extracellular collagen I reveals parallels of gelation and fibrillar structure. 2004 Feb 27 2
49 11248668 The protein kinase Cdk5. Structural aspects, roles in neurogenesis and involvement in Alzheimer's pathology. 2001 Mar 1
50 11550225 Hyperosmotic stress-induced apoptosis and tau phosphorylation in human neuroblastoma cells. 2001 Sep 15 2