Lysine

⇄

microtubule associated protein tau ; Homo sapiens







42 Article(s)
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1 34545670 Enhanced identification of Tau acetylation and phosphorylation with an engineered aerolysin nanopore. 2022 Mar 1
2 34796642 Charge neutralization of lysine via carbamylation reveals hidden aggregation hot-spots in tau protein flanking regions. 2022 May 4
3 34838590 Post-translational modifications within tau paired helical filament nucleating motifs perturb microtubule interactions and oligomer formation. 2022 Jan 2
4 35016968 Ubiquitination of Alzheimer's-related tau protein affects liquid-liquid phase separation in a site- and cofactor-dependent manner. 2022 Mar 15 1
5 35202653 Lysine 63-linked ubiquitination of tau oligomers contributes to the pathogenesis of Alzheimer's disease. 2022 Apr 1
6 35231567 Methylation at a conserved lysine residue modulates tau assembly and cellular functions. 2022 May 3
7 35257729 The role of non-enzymatic glycation on Tau-DNA interactions: Kinetic and mechanistic approaches. 2022 May 15 1
8 33496017 The Lys 280 → Gln mutation mimicking disease-linked acetylation of Lys 280 in tau extends the structural core of fibrils and modulates their catalytic properties. 2021 Apr 7
9 33683887 Global Profiling of Lysine Accessibility to Evaluate Protein Structure Changes in Alzheimer's Disease. 2021 Apr 7 1
10 33962636 Methylation as a key regulator of Tau aggregation and neuronal health in Alzheimer's disease. 2021 May 7 2
11 34039738 PAC1 receptor-mediated clearance of tau in postsynaptic compartments attenuates tau pathology in mouse brain. 2021 May 26 1
12 34215303 SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer's disease. 2021 Jul 2 2
13 34569575 Thermodynamics and structural characterization of the nickel(II) and zinc(II) complexes of various peptide fragments of tau protein. 2021 Oct 19 1
14 34966788 Unraveling the Influence of K280 Acetylation on the Conformational Features of Tau Core Fragment: A Molecular Dynamics Simulation Study. 2021 1
15 32575755 Semisynthetic Modification of Tau Protein with Di-Ubiquitin Chains for Aggregation Studies. 2020 Jun 20 1
16 30992364 Tau repeat regions contain conserved histidine residues that modulate microtubule-binding in response to changes in pH. 2019 May 31 1
17 31266957 Lysine/RNA-interactions drive and regulate biomolecular condensation. 2019 Jul 2 3
18 29684271 Protein Semisynthesis Provides Access to Tau Disease-Associated Post-translational Modifications (PTMs) and Paves the Way to Deciphering the Tau PTM Code in Health and Diseased States. 2018 May 30 1
19 27975250 Mass Spectrometry Analysis of Lysine Posttranslational Modifications of Tau Protein from Alzheimer's Disease Brain. 2017 4
20 28083916 Acetylated tau in Alzheimer's disease: An instigator of synaptic dysfunction underlying memory loss: Increased levels of acetylated tau blocks the postsynaptic signaling required for plasticity and promotes memory deficits associated with tauopathy. 2017 Apr 3
21 28760828 An acetylation-phosphorylation switch that regulates tau aggregation propensity and function. 2017 Sep 15 1
22 28819146 Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau. 2017 Aug 17 1
23 26940749 Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo. 2016 Mar 4 3
24 27041503 Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss. 2016 Apr 20 1
25 27383765 Intrinsic Tau Acetylation Is Coupled to Auto-Proteolytic Tau Fragmentation. 2016 4
26 22033876 Dual modification of Alzheimer's disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach. 2012 Jan 3
27 21427723 The acetylation of tau inhibits its function and promotes pathological tau aggregation. 2011 2
28 17723255 Clinical and pathological features of an Alzheimer's disease patient with the MAPT Delta K280 mutation. 2009 Mar 2
29 16443603 Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation. 2006 Apr 21 9
30 16464864 Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and alpha-synuclein. 2006 Apr 14 1
31 11738469 Transglutaminase bonds in neurofibrillary tangles and paired helical filament tau early in Alzheimer's disease. 2002 Jan 4
32 10936206 In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification. 2000 Sep 1
33 10412802 A mutation at codon 279 (N279K) in exon 10 of the Tau gene causes a tauopathy with dementia and supranuclear palsy. 1999 Jul 1
34 10537045 Tau is modified by tissue transglutaminase in situ: possible functional and metabolic effects of polyamination. 1999 Nov 1
35 10642839 Elevated transglutaminase-induced bonds in PHF tau in Alzheimer's disease. 1999 Dec 18 2
36 9846894 Modification of tau to an Alzheimer's type protein interferes with its interaction with microtubules. 1998 Nov 2
37 7561862 Tau protein from Alzheimer's disease patients is glycated at its tubulin-binding domain. 1995 Oct 5
38 7509372 Amino acid residues 226-240 of tau, which encompass the first Lys-Ser-Pro site of tau, are partially phosphorylated in Alzheimer paired helical filament-tau. 1994 Mar 3
39 8348591 Functional domains on chemically modified tau protein. 1993 Apr 2
40 8512563 Brain protein kinase PK40erk converts TAU into a PHF-like form as found in Alzheimer's disease. 1993 Jun 15 1
41 1281953 Immunocytochemistry of neurofibrillary tangles with antibodies to subregions of tau protein: identification of hidden and cleaved tau epitopes and a new phosphorylation site. 1992 1
42 1939196 Abnormal tau proteins from Alzheimer's disease brains. Purification and amino acid analysis. 1991 Nov 15 1