11-(2-pyrrolidin-1-ylethoxy)-14,19-dioxa-5,7,26-triazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene

fms related receptor tyrosine kinase 3 ; Homo sapiens







23 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
1 31102119 Preclinical activity and a pilot phase I study of pacritinib, an oral JAK2/FLT3 inhibitor, and chemotherapy in FLT3-ITD-positive AML. 2020 Apr 7
2 29235894 Pacritinib and its use in the treatment of patients with myelofibrosis who have thrombocytopenia. 2018 Apr 1
3 29616317 Outcomes of patients with myelofibrosis treated with compassionate use pacritinib: a sponsor-independent international study. 2018 Aug 2
4 29743719 Inhibition of interleukin-1 receptor-associated kinase-1 is a therapeutic strategy for acute myeloid leukemia subtypes. 2018 Nov 2
5 29785143 Pilot study of the antifibrotic effects of the multikinase inhibitor pacritinib in a mouse model of liver fibrosis. 2018 1
6 30001163 Pacritinib to treat myelofibrosis patients with thrombocytopenia. 2018 Sep 1
7 28336242 Pacritinib versus best available therapy for the treatment of myelofibrosis irrespective of baseline cytopenias (PERSIST-1): an international, randomised, phase 3 trial. 2017 May 1
8 28576879 Robust patient-derived xenografts of MDS/MPN overlap syndromes capture the unique characteristics of CMML and JMML. 2017 Jul 27 1
9 27226728 Emerging treatment options for myelofibrosis: focus on pacritinib. 2016 2
10 27334834 Colony-Stimulating Factor-1 Receptor Is Required for Nurse-like Cell Survival in Chronic Lymphocytic Leukemia. 2016 Dec 15 1
11 27598824 The development, safety and efficacy of pacritinib for the treatment of myelofibrosis. 2016 Nov 1
12 27931243 Phase 1/2 study of pacritinib, a next generation JAK2/FLT3 inhibitor, in myelofibrosis or other myeloid malignancies. 2016 Dec 8 3
13 25762180 Results of a phase 2 study of pacritinib (SB1518), a JAK2/JAK2(V617F) inhibitor, in patients with myelofibrosis. 2015 Apr 23 2
14 26288713 Clinical potential of pacritinib in the treatment of myelofibrosis. 2015 Aug 2
15 26367195 A comprehensive review of pacritinib in myelofibrosis. 2015 1
16 26389774 Pacritinib: a new agent for the management of myelofibrosis? 2015 1
17 24746271 The role of pacritinib in the management of myelofibrosis. 2014 Jun 1
18 25170285 Profile of pacritinib and its potential in the treatment of hematologic disorders. 2014 3
19 23442043 Targeting the JAK-STAT pathway in lymphoma: a focus on pacritinib. 2013 Jun 2
20 22527961 Structure-based design of oxygen-linked macrocyclic kinase inhibitors: discovery of SB1518 and SB1578, potent inhibitors of Janus kinase 2 (JAK2) and Fms-like tyrosine kinase-3 (FLT3). 2012 Apr 4
21 22829971 The oral HDAC inhibitor pracinostat (SB939) is efficacious and synergistic with the JAK2 inhibitor pacritinib (SB1518) in preclinical models of AML. 2012 May 1
22 21691275 SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies. 2011 Nov 3
23 22829080 Pacritinib (SB1518), a JAK2/FLT3 inhibitor for the treatment of acute myeloid leukemia. 2011 Nov 8