7-hydroxystaurosporine

cyclin dependent kinase 2 ; Homo sapiens







7 Article(s)
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1 16284058 Phase I trial of UCN-01 in combination with topotecan in patients with advanced solid cancers: a Princess Margaret Hospital Phase II Consortium study. 2006 Feb 1
2 15169628 Abrogation of Chk1-mediated S/G2 checkpoint by UCN-01 enhances ara-C-induced cytotoxicity in human colon cancer cells. 2004 Jun 1
3 12181445 Inhibition of cyclin-dependent kinase 2 by the Chk1-Cdc25A pathway during the S-phase checkpoint activated by fludarabine: dysregulation by 7-hydroxystaurosporine. 2002 Sep 1
4 12191604 Structural studies with inhibitors of the cell cycle regulatory kinase cyclin-dependent protein kinase 2. 2002 Feb-Mar 3
5 10665655 G1-checkpoint function including a cyclin-dependent kinase 2 regulatory pathway as potential determinant of 7-hydroxystaurosporine (UCN-01)-induced apoptosis and G1-phase accumulation. 1999 Dec 1
6 8645257 UCN-01, 7-hydroxyl-staurosporine, inhibits kinase activity of cyclin-dependent kinases and reduces the phosphorylation of the retinoblastoma susceptibility gene product in A549 human lung cancer cell line. 1996 Feb 27 2
7 7574801 [Cell cycle regulation by anticancer agent]. 1995 Oct 1