Acetaminophen

peroxisome proliferator activated receptor alpha ; Mus musculus







14 Article(s)
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Pub. Year
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1 35414769 Disruption of peroxisome proliferator-activated receptor α in hepatocytes protects against acetaminophen-induced liver injury by activating the IL-6/STAT3 pathway. 2022 4
2 33395599 Sleep disorders are associated with acetaminophen-induced adverse reactions and liver injury. 2021 Feb 1
3 29730296 FGF21 mediates the protective effect of fenofibrate against acetaminophen -induced hepatotoxicity via activating autophagy in mice. 2018 Sep 5 2
4 28583670 Hepatic hypoxia-inducible factors inhibit PPARα expression to exacerbate acetaminophen induced oxidative stress and hepatotoxicity. 2017 Sep 1
5 26398229 Loss of 5-lipoxygenase activity protects mice against paracetamol-induced liver toxicity. 2016 Jan 1
6 26850476 Enhanced hepatotoxicity by acetaminophen in Vanin-1 knockout mice is associated with deficient proliferative and immune responses. 2016 Apr 4
7 25689681 Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) in a mouse liver gene expression compendium. 2015 1
8 22318764 Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity. 2012 Jul 3
9 19256530 Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity. 2009 Apr 4
10 18501395 Nonalcoholic steatohepatitic (NASH) mice are protected from higher hepatotoxicity of acetaminophen upon induction of PPARalpha with clofibrate. 2008 Aug 1 4
11 12958197 Activation of PPAR-alpha in streptozotocin-induced diabetes is essential for resistance against acetaminophen toxicity. 2003 Sep 2
12 11006348 PPAR-alpha: a key to the mechanism of hepatoprotection by clofibrate. 2000 Oct 1
13 11006363 Peroxisome proliferator-activated receptor alpha-null mice lack resistance to acetaminophen hepatotoxicity following clofibrate exposure. 2000 Oct 3
14 10522648 The PPAR activator docosahexaenoic acid prevents acetaminophen hepatotoxicity in male CD-1 mice. 1999 Oct 15 3