epibatidine

⇄

cholinergic receptor nicotinic alpha 4 subunit ; Homo sapiens







44 Article(s)
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1 28935799 Interacting amino acid replacements allow poison frogs to evolve epibatidine resistance. 2017 Sep 22 4
2 27493220 Crystal structure of a human neuronal nAChR extracellular domain in pentameric assembly: Ligand-bound α2 homopentamer. 2016 Aug 23 2
3 25180076 Functional characterization of AT-1001, an α3β4 nicotinic acetylcholine receptor ligand, at human α3β4 and α4β2 nAChR. 2015 Mar 1
4 24369841 Synthesis and biological evaluation of both enantiomers of [(18)F]flubatine, promising radiotracers with fast kinetics for the imaging of α4β2-nicotinic acetylcholine receptors. 2014 Jan 15 1
5 22320303 Neuroprotective properties of nicotine. 2012 2
6 22112852 Characterizing low affinity epibatidine binding to α4β2 nicotinic acetylcholine receptors with ligand depletion and nonspecific binding. 2011 Nov 23 2
7 19479336 Computational analysis of the binding ability of heterocyclic and conformationally constrained epibatidine analogs in the neuronal nicotinic acetylcholine receptor. 2010 May 3
8 20849857 A component of Premarin(®) enhances multiple cognitive functions and influences nicotinic receptor expression. 2010 Nov 1
9 18818999 Contribution of position alpha4S336 on functional expression and up-regulation of alpha4beta2 neuronal nicotinic receptors. 2009 Feb 1
10 19111588 Nicotinic receptor agonists and antagonists increase sAPPalpha secretion and decrease Abeta levels in vitro. 2009 Mar-Apr 1
11 19620239 [(3)H]Epibatidine photolabels non-equivalent amino acids in the agonist binding site of Torpedo and alpha4beta2 nicotinic acetylcholine receptors. 2009 Sep 11 3
12 25530665 EPIBATIDINE ANALOGS SYNTHESIZED FOR CHARACTERIZATION OF NICOTINIC PHARMACOPHORES-A REVIEW. 2009 3
13 17977823 Tumor necrosis factor alpha enhances nicotinic receptor up-regulation via a p38MAPK-dependent pathway. 2008 Jan 11 1
14 18083118 Epibatidine binds to four sites on the Torpedo nicotinic acetylcholine receptor. 2008 Feb 15 3
15 17141870 Differential nicotinic regulation of the nigrostriatal and mesolimbic dopaminergic pathways: implications for drug development. 2007 3
16 17314009 JN403, in vitro characterization of a novel nicotinic acetylcholine receptor alpha7 selective agonist. 2007 Apr 6 1
17 17585748 Structure-activity studies and analgesic efficacy of N-(3-pyridinyl)-bridged bicyclic diamines, exceptionally potent agonists at nicotinic acetylcholine receptors. 2007 Jul 26 1
18 17662959 Neuronal nicotinic receptors: a perspective on two decades of drug discovery research. 2007 Oct 15 1
19 16934977 Epibatidine isomers and analogues: structure-activity relationships. 2006 Nov 1 1
20 15356217 Heterologous expression of human {alpha}6{beta}4{beta}3{alpha}5 nicotinic acetylcholine receptors: binding properties consistent with their natural expression require quaternary subunit assembly including the {alpha}5 subunit. 2005 Feb 1
21 16039849 Epibatidine analogues as selective ligands for the alpha(x)beta2-containing subtypes of nicotinic acetylcholine receptors. 2005 Oct 1 1
22 14715938 Nicotinic enhancement of the noradrenergic inhibition of sleep-promoting neurons in the ventrolateral preoptic area. 2004 Jan 7 3
23 14965298 Recent developments in the synthesis of nicotinic acetylcholine receptor ligands. 2004 2
24 14965300 Rational understanding of nicotinic receptors drug binding. 2004 1
25 14983978 Modulators of nicotinic acetylcholine receptors as analgesics. 2004 Jan 1
26 15050621 Epibatidine structure-activity relationships. 2004 Apr 19 1
27 15474055 Norchloro-fluoro-homoepibatidine: specificity to neuronal nicotinic acetylcholine receptor subtypes in vitro. 2004 Oct 3
28 20641651 [18F]Norchloro-fluoro-homoepibatidine 2004 1
29 12620422 Cytisine derivatives as ligands for neuronal nicotine receptors and with various pharmacological activities. 2003 Mar 1
30 14645658 Characterization of human alpha 4 beta 2-nicotinic acetylcholine receptors stably and heterologously expressed in native nicotinic receptor-null SH-EP1 human epithelial cells. 2003 Dec 1
31 12769608 Recent progress in the development of subtype selective nicotinic acetylcholine receptor ligands. 2002 Aug 1
32 11135003 Effect of nicotine on cerebellar granule neuron development. 2001 Jan 1
33 11772288 The therapeutic potential of nicotinic acetylcholine receptor agonists for pain control. 2001 Oct 1
34 10773216 Nicotine reverses GABAergic inhibition of long-term potentiation induction in the hippocampal CA1 region. 2000 Apr 28 2
35 10812948 Recombinant human receptors and functional assays in the discovery of altinicline (SIB-1508Y), a novel acetylcholine-gated ion channel (nAChR) agonist. 2000 Mar 1
36 10072197 Characterization of the nicotinic ligand 2-[18F]fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine in vivo. 1999 1
37 10359088 Neuronal nAChR stereoselectivity to non-natural epibatidine derivatives. 1999 May 7 1
38 10509744 Therapeutic potential of neuronal nicotinic acetylcholine receptor agonists as novel analgesics. 1999 Sep 15 2
39 9572289 Regulation of nicotinic receptor subtypes following chronic nicotinic agonist exposure in M10 and SH-SY5Y neuroblastoma cells. 1998 May 1
40 9580626 ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization. 1998 May 2
41 9584223 Agonist-induced up-regulation of alpha4beta2 nicotinic acetylcholine receptors in M10 cells: pharmacological and spatial definition. 1998 May 1
42 9585143 The potential of subtype-selective neuronal nicotinic acetylcholine receptor agonists as therapeutic agents. 1998 1
43 9282914 Evidence for nicotinic receptors potentially modulating nociceptive transmission at the level of the primary sensory neuron: studies with F11 cells. 1997 Sep 3
44 7480004 Cholinergic channel activators: novel opportunities for the treatment of CNS disorders. 1995 1