Camptothecin

hypoxia inducible factor 1 subunit alpha ; Homo sapiens







9 Article(s)
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1 31927166 Measurement of NLG207 (formerly CRLX101) nanoparticle-bound and released camptothecin in human plasma. 2020 Mar 20 1
2 28950297 A randomized phase II trial of CRLX101 in combination with bevacizumab versus standard of care in patients with advanced renal cell carcinoma. 2017 Nov 1 1
3 27457310 Efficacy of the nanoparticle-drug conjugate CRLX101 in combination with bevacizumab in metastatic renal cell carcinoma: results of an investigator-initiated phase I-IIa clinical trial. 2016 Aug 1
4 24242862 Weekly EZN-2208 (PEGylated SN-38) in combination with bevacizumab in patients with refractory solid tumors. 2014 Apr 1
5 24252850 The natural inhibitor of DNA topoisomerase I, camptothecin, modulates HIF-1α activity by changing miR expression patterns in human cancer cells. 2014 Jan 9
6 19854946 DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1alpha gene locus. 2010 Jan 1
7 20479887 Inhibition of hypoxia-inducible factor-1alpha (HIF-1alpha) protein synthesis by DNA damage inducing agents. 2010 May 7 3
8 20600630 Dissecting the transcriptional functions of human DNA topoisomerase I by selective inhibitors: implications for physiological and therapeutic modulation of enzyme activity. 2010 Dec 2
9 14983893 Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications. 2004 Feb 15 4