| 1 |
35415275 | Role of prolyl hydroxylase domain proteins in bone metabolism. | 2022 Mar |
2 |
| 2 |
34537235 | HIF-1α Hydroxyprolines Modulate Oxygen-Dependent Protein Stability Via Single VHL Interface With Comparable Effect on Ubiquitination Rate. | 2021 Nov 5 |
1 |
| 3 |
34781297 | Lentivirus-shRNA mediated prolyl hydroxylase 2 knockdown increases HIF-1α and inhibits nucleus pulposus cells degeneration. | 2021 Nov 15 |
1 |
| 4 |
34943229 | Understanding the Role of Estrogen Receptor Status in PRODH/POX-Dependent Apoptosis/Survival in Breast Cancer Cells. | 2021 Dec 10 |
2 |
| 5 |
32256584 | Pathological Mechanistic Studies of Osimertinib Resistance in Non-Small-Cell Lung Cancer Cells Using an Integrative Metabolomics-Proteomics Analysis. | 2020 |
1 |
| 6 |
32377733 | Vitamin C decreases VEGF expression levels via hypoxia‑inducible factor‑1α dependent and independent pathways in lens epithelial cells. | 2020 Jul |
2 |
| 7 |
30796332 | 4-O-Methylascochlorin inhibits the prolyl hydroxylation of hypoxia-inducible factor-1α, which is attenuated by ascorbate. | 2019 May |
1 |
| 8 |
31413262 | Intrabody against prolyl hydroxylase 2 promotes angiogenesis by stabilizing hypoxia-inducible factor-1α. | 2019 Aug 14 |
1 |
| 9 |
29084919 | Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma. | 2018 Jan 15 |
2 |
| 10 |
29568391 | Proline oxidase silencing induces proline-dependent pro-survival pathways in MCF-7 cells. | 2018 Mar 2 |
1 |
| 11 |
29961792 | Proline hydroxylation at different sites in hypoxia-inducible factor 1α modulates its interactions with the von Hippel-Lindau tumor suppressor protein. | 2018 Jul 11 |
1 |
| 12 |
30367042 | Collagen prolyl 4-hydroxylase 1 is essential for HIF-1α stabilization and TNBC chemoresistance. | 2018 Oct 26 |
1 |
| 13 |
28526934 | Exogenous proline stimulates type I collagen and HIF-1α expression and the process is attenuated by glutamine in human skin fibroblasts. | 2017 Nov |
1 |
| 14 |
29037142 | Enzyme-Substrate Reporters for Evaluation of Substrate Specificity of HIF Prolyl Hydroxylase Isoforms. | 2017 Oct |
1 |
| 15 |
26757928 | Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis. | 2016 Jan 13 |
1 |
| 16 |
26997627 | Role of prolyl hydroxylase domain proteins in the regulation of insulin secretion. | 2016 Mar |
4 |
| 17 |
27598034 | 15-Deoxy-Δ12,14-prostaglandin J2 stabilizes hypoxia inducible factor-1α through induction of heme oxygenase-1 and direct modification ofprolyl-4-hydroxylase 2. | 2016 Oct |
1 |
| 18 |
26574473 | Quantifying the Binding Interaction between the Hypoxia-Inducible Transcription Factor and the von Hippel-Lindau Suppressor. | 2015 Aug 11 |
1 |
| 19 |
26600509 | Correlation between polymorphisms of hypoxia-inducible factor-1α Pro582Ser and type 2 diabetic nephropathy. | 2015 Nov 19 |
1 |
| 20 |
26628999 | Vitamin C inhibit the proliferation, migration and epithelial-mesenchymal-transition of lens epithelial cells by destabilizing HIF-1α. | 2015 |
2 |
| 21 |
23542169 | RUNX3 inhibits hypoxia-inducible factor-1α protein stability by interacting with prolyl hydroxylases in gastric cancer cells. | 2014 Mar 13 |
6 |
| 22 |
24563687 | Proline-hydroxylated hypoxia-inducible factor 1α (HIF-1α) upregulation in human tumours. | 2014 |
8 |
| 23 |
23416007 | A multivalent peptide as an activator of hypoxia inducible factor-1α. | 2013 Mar 15 |
2 |
| 24 |
23487784 | Estrogen receptor β sustains epithelial differentiation by regulating prolyl hydroxylase 2 transcription. | 2013 Mar 19 |
1 |
| 25 |
23886708 | In silico investigation of PHD-3 specific HIF1-α proline 567 hydroxylation: a new player in the VHL/HIF-1α interaction pathway? | 2013 Sep 17 |
2 |
| 26 |
24132642 | A novel prolyl hydroxylase inhibitor protects against cell death after hypoxia. | 2013 Dec |
2 |
| 27 |
21993963 | Thrombin-dependent modulation of β1-integrin-mediated signaling up-regulates prolidase and HIF-1α through p-FAK in colorectal cancer cells. | 2012 Feb |
2 |
| 28 |
22181812 | Iron facilitator LS081 reduces hypoxia-inducible factor-1α protein and functions as anticancer agent in hepatocellular carcinoma. | 2012 Apr |
1 |
| 29 |
22286099 | The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. | 2012 Jan 29 |
2 |
| 30 |
21287578 | An activator of PHD2, KRH102140, decreases angiogenesis via inhibition of HIF-1α. | 2011 Mar |
1 |
| 31 |
21335549 | Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors. | 2011 Apr 15 |
1 |
| 32 |
21344271 | HIF1A P582S gene association with endurance training responses in young women. | 2011 Sep |
1 |
| 33 |
21410436 | Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites. | 2011 Jun 1 |
1 |
| 34 |
21785006 | Regulation of metabolism by hypoxia-inducible factor 1. | 2011 |
1 |
| 35 |
22134239 | Oxygen sensing is impaired in ATM-defective cells. | 2011 Dec 15 |
1 |
| 36 |
19958256 | The antioxidant quercetin inhibits cellular proliferation via HIF-1-dependent induction of p21WAF. | 2010 Aug 15 |
2 |
| 37 |
20216986 | The adaptor protein Ruk/CIN85 activates plasminogen activator inhibitor-1 (PAI-1) expression via hypoxia-inducible factor-1alpha. | 2010 May |
1 |
| 38 |
20416277 | Hinokitiol activates the hypoxia-inducible factor (HIF) pathway through inhibition of HIF hydroxylases. | 2010 May 28 |
1 |
| 39 |
20461086 | PHD2 in tumour angiogenesis. | 2010 Jun 29 |
2 |
| 40 |
20675386 | Stabilization of hypoxia-inducible factor-1alpha protein in hypoxia occurs independently of mitochondrial reactive oxygen species production. | 2010 Oct 8 |
6 |
| 41 |
20967267 | Abnormalities in oxygen sensing define early and late onset preeclampsia as distinct pathologies. | 2010 Oct 12 |
1 |
| 42 |
20972335 | Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-α isoforms and promotes angiogenesis. | 2010 Nov |
1 |
| 43 |
19498081 | Characterization of a robust enzymatic assay for inhibitors of 2-oxoglutarate-dependent hydroxylases. | 2009 Jul |
1 |
| 44 |
19515556 | HIF-1alpha peptide derivatives with modifications at the hydroxyproline residue as activators of HIF-1alpha. | 2009 Aug 1 |
10 |
| 45 |
19603255 | Adenovirus-mediated hypoxia-inducible factor 1alpha double-mutant promotes differentiation of bone marrow stem cells to cardiomyocytes. | 2009 Nov |
5 |
| 46 |
17942596 | Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion. | 2008 Jan |
2 |
| 47 |
18426857 | Nitric oxide donor, (+/-)-S-nitroso-N-acetylpenicillamine, stabilizes transactive hypoxia-inducible factor-1alpha by inhibiting von Hippel-Lindau recruitment and asparagine hydroxylation. | 2008 Jul |
1 |
| 48 |
18440561 | Activation of C-transactivation domain is essential for optimal HIF-1 alpha-mediated transcriptional and angiogenic effects. | 2008 May |
1 |
| 49 |
18503779 | Solid tumor physiology and hypoxia-induced chemo/radio-resistance: novel strategy for cancer therapy: nitric oxide donor as a therapeutic enhancer. | 2008 Sep |
2 |
| 50 |
18578010 | Double oxygen-sensing vector system for robust hypoxia/ischemia-regulated gene induction in cardiac muscle in vitro and in vivo. | 2008 Sep |
1 |