Uric Acid

NLR family, pyrin domain containing 3 ; Mus musculus







60 Article(s)
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1 34376811 Gout-associated monosodium urate crystal-induced necrosis is independent of NLRP3 activity but can be suppressed by combined inhibitors for multiple signaling pathways. 2022 May 4
2 34586567 Effects of Gentiopicroside on activation of NLRP3 inflammasome in acute gouty arthritis mice induced by MSU. 2022 Jan 4
3 34619319 Guizhi-Shaoyao-Zhimu decoction attenuates monosodium urate crystal-induced inflammation through inactivation of NF-κB and NLRP3 inflammasome. 2022 Jan 30 1
4 34965184 The protective effects of S14G-humanin (HNG) against mono-sodium urate (MSU) crystals- induced gouty arthritis. 2022 Jan 1
5 35368226 Kv1.5 channel mediates monosodium urate-induced activation of NLRP3 inflammasome in macrophages and arrhythmogenic effects of urate on cardiomyocytes. 2022 Apr 4 1
6 32761488 Preventive effect of dioscin against monosodium urate-mediated gouty arthritis through inhibiting inflammasome NLRP3 and TLR4/NF-κB signaling pathway activation: an in vivo and in vitro study. 2021 Jan 1
7 33074353 Uric acid drives intestinal barrier dysfunction through TSPO-mediated NLRP3 inflammasome activation. 2021 Jan 3
8 33232925 Uric acid aggravates myocardial ischemia-reperfusion injury via ROS/NLRP3 pyroptosis pathway. 2021 Jan 4
9 33242555 Andrographolide inhibits IL-1β release in bone marrow-derived macrophages and monocyte infiltration in mouse knee joints induced by monosodium urate. 2021 Jan 1 6
10 33517224 Curcumin analogue AI-44 alleviates MSU-induced gouty arthritis in mice via inhibiting cathepsin B-mediated NLRP3 inflammasome activation. 2021 Apr 1
11 33615201 Regulatory T cells induced by B cells suppress NLRP3 inflammasome activation and alleviate monosodium urate-induced gouty inflammation. 2021 Feb 19 1
12 33746978 Decoy Receptor 3 Inhibits Monosodium Urate-Induced NLRP3 Inflammasome Activation via Reduction of Reactive Oxygen Species Production and Lysosomal Rupture. 2021 3
13 33854503 Lactic Acid Fermentation Is Required for NLRP3 Inflammasome Activation. 2021 2
14 34007200 microRNA-223 Deficiency Exacerbates Acute Inflammatory Response to Monosodium Urate Crystals by Targeting NLRP3. 2021 1
15 34025639 Total Flavonoids of Glycyrrhiza uralensis Alleviates Irinotecan-Induced Colitis via Modification of Gut Microbiota and Fecal Metabolism. 2021 2
16 34047713 NLRP3 inflammasome inhibitor cucurbitacin B suppresses gout arthritis in mice. 2021 Jun 21 2
17 34284768 Effects of Stephania hainanensis alkaloids on MSU-induced acute gouty arthritis in mice. 2021 Jul 20 1
18 34359507 MicroRNAs Involved in the Therapeutic Functions of Noni (Morinda citrifolia L.) Fruit Juice in the Treatment of Acute Gouty Arthritis in Mice Induced with Monosodium Urate. 2021 Jul 15 3
19 34377468 Native and oxidised lipoproteins negatively regulate the serum amyloid A-induced NLRP3 inflammasome activation in human macrophages. 2021 1
20 34440688 Lower Temperatures Exacerbate NLRP3 Inflammasome Activation by Promoting Monosodium Urate Crystallization, Causing Gout. 2021 Jul 29 3
21 34577821 Ameliorative Effects of Cardamonin on Monosodium Urate-Induced Gouty Arthritis through Inhibiting NLRP3 Inflammasome Mediation. 2021 Aug 28 2
22 34803702 Active Flavonoids From Lagotis brachystachya Attenuate Monosodium Urate-Induced Gouty Arthritis via Inhibiting TLR4/MyD88/NF-κB Pathway and NLRP3 Expression. 2021 3
23 31790902 Phloretin ameliorates hyperuricemia-induced chronic renal dysfunction through inhibiting NLRP3 inflammasome and uric acid reabsorption. 2020 Jan 1
24 31918161 IκBζ controls NLRP3 inflammasome activation via upregulation of the Nlrp3 gene. 2020 Mar 1
25 31979265 Synthetic 4-Hydroxy Auxarconjugatin B, a Novel Autophagy Inducer, Attenuates Gouty Inflammation by Inhibiting the NLRP3 Inflammasome. 2020 Jan 23 3
26 32595041 EPS8 regulates an NLRP3 inflammasome-independent caspase-1 activation pathway in monosodium urate crystal-treated RAW264.7 macrophages. 2020 Sep 24 2
27 32700178 Toll-Like Receptor 9 Is Involved in NLRP3 Inflammasome Activation and IL-1β Production Through Monosodium Urate-Induced Mitochondrial DNA. 2020 Dec 8
28 33017103 Inflammasome Assays In Vitro and in Mouse Models. 2020 Dec 2
29 33117389 DAMPs in Unilateral Ureteral Obstruction. 2020 2
30 31084401 Pharmacological basis for use of madecassoside in gouty arthritis: anti-inflammatory, anti-hyperuricemic, and NLRP3 inhibition. 2019 Apr 1
31 31455356 Curcumin attenuates MSU crystal-induced inflammation by inhibiting the degradation of IκBα and blocking mitochondrial damage. 2019 Aug 27 1
32 31803174 Caspase-11 Mediates Neutrophil Chemotaxis and Extracellular Trap Formation During Acute Gouty Arthritis Through Alteration of Cofilin Phosphorylation. 2019 1
33 29279328 Hydrogen sulfide inhibits NLRP3 inflammasome activation and reduces cytokine production both in vitro and in a mouse model of inflammation. 2018 Feb 16 2
34 29804160 Melatonin Suppresses Estrogen Deficiency-Induced Osteoporosis and Promotes Osteoblastogenesis by Inactivating the NLRP3 Inflammasome. 2018 Oct 1
35 28376889 Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression. 2017 Apr 4 3
36 29118366 BOT-4-one attenuates NLRP3 inflammasome activation: NLRP3 alkylation leading to the regulation of its ATPase activity and ubiquitination. 2017 Nov 8 1
37 26449770 Transmembrane TNF-α is sufficient for articular inflammation and hypernociception in a mouse model of gout. 2016 Jan 2
38 26639394 Uric acid regulates hepatic steatosis and insulin resistance through the NLRP3 inflammasome-dependent mechanism. 2016 Apr 2
39 26642356 NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component. 2016 Mar 1
40 27010539 Characterization and Activation of NLRP3 Inflammasomes in the Renal Medulla in Mice. 2016 3
41 27934918 Targeting ASC in NLRP3 inflammasome by caffeic acid phenethyl ester: a novel strategy to treat acute gout. 2016 Dec 9 1
42 25681332 The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes. 2015 Mar 15 1
43 25914377 A Role for Gut Microbiota and the Metabolite-Sensing Receptor GPR43 in a Murine Model of Gout. 2015 Jun 2
44 22933241 Orthopedic wear debris mediated inflammatory osteolysis is mediated in part by NALP3 inflammasome activation. 2013 Jan 2
45 23387472 Inhibition of UV-induced uric acid production using allopurinol prevents suppression of the contact hypersensitivity response. 2013 Mar 2
46 23609011 Cellular localization of NLRP3 inflammasome. 2013 Jun 1
47 23619996 The NLRP3 inflammasome affects DNA damage responses after oxidative and genotoxic stress in dendritic cells. 2013 Aug 2
48 23852596 NLRP3 inflammasome activation and cytotoxicity induced by particulate adjuvants. 2013 2
49 23980097 The Nlrp3 inflammasome regulates acute graft-versus-host disease. 2013 Sep 23 1
50 22147847 Inflammasome-IL-1-Th17 response in allergic lung inflammation. 2012 Feb 1