4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide

prostaglandin-endoperoxide synthase 2 ; Homo sapiens







27 Article(s)
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1 32902737 Reduction in MicroRNA-4488 Expression Induces NFκB Translocation in Venous Endothelial Cells Under Arterial Flow. 2021 Feb 1
2 28239377 Pro-inflammatory Signaling in a 3D Organotypic Skin Model after Low LET Irradiation-NF-κB, COX-2 Activation, and Impact on Cell Differentiation. 2017 2
3 32261432 Highly efficient gene transfection by a hyperosmotic polymannitol based gene tranporter through regulation of caveolae and COX-2 induced endocytosis. 2014 May 14 2
4 21565206 Effects of adrenaline in human colon adenocarcinoma HT-29 cells. 2011 Jun 20 1
5 21978392 Inhibition of cyclo-oxygenase 2 reduces tumor metastasis and inflammatory signaling during blockade of vascular endothelial growth factor. 2011 Oct 6 1
6 20067770 Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor. 2010 May 15 1
7 19558693 Proneoplastic effects of PGE2 mediated by EP4 receptor in colorectal cancer. 2009 Jun 26 1
8 18805435 Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induce cyclooxygenase-2 activity in human gastric cancer cells: Involvement of nicotinic acetylcholine receptor (nAChR) and beta-adrenergic receptor signaling pathways. 2008 Dec 1 1
9 17196403 A selective cyclooxygenase-2 inhibitor decreases transforming growth factor-beta1 synthesis and matrix production in human peritoneal mesothelial cells. 2007 May 4
10 17409426 Nonsteroidal anti-inflammatory drugs induce colorectal cancer cell apoptosis by suppressing 14-3-3epsilon. 2007 Apr 1 2
11 16297879 eNOS, COX-2, and prostacyclin production are impaired in endothelial cells from diabetics. 2006 Jan 6 2
12 16618763 Inhibition of cyclooxygenase-2 disrupts tumor vascular mural cell recruitment and survival signaling. 2006 Apr 15 2
13 16641552 Inhibition of Akt/PKB by a COX-2 inhibitor induces apoptosis in gastric cancer cells. 2006 1
14 15784648 Cyclooxygenase-2 inhibitor SC-236 [4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1-pyrazol-1-l] benzenesulfonamide] suppresses nuclear factor-kappaB activation and phosphorylation of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase, and c-Jun N-terminal kinase in human mast cell line cells. 2005 Jul 1
15 15816526 The effect of cyclooxygenase-2 (COX-2) inhibition on human prostate cancer induced osteoblastic and osteolytic lesions in bone. 2005 Jan-Feb 1
16 15878334 Mitochondrial localization of cyclooxygenase-2 and calcium-independent phospholipase A2 in human cancer cells: implication in apoptosis resistance. 2005 May 15 1
17 15993407 Cyclooxygenase-2 in cancer cells and macrophages induces colon cancer cell growth by cigarette smoke extract. 2005 Jul 25 1
18 16317086 Nicotine induces cyclooxygenase-2 and vascular endothelial growth factor receptor-2 in association with tumor-associated invasion and angiogenesis in gastric cancer. 2005 Nov 1
19 14607840 Hypertonic stress activates glycogen synthase kinase 3beta-mediated apoptosis of renal medullary interstitial cells, suppressing an NFkappaB-driven cyclooxygenase-2-dependent survival pathway. 2004 Feb 6 2
20 14699495 Cyclooxygenase-2 inhibitor (SC-236) suppresses activator protein-1 through c-Jun NH2-terminal kinase. 2004 Jan 1
21 14962510 A mechanistic study of cigarette smoke and cyclooxygenase-2 on proliferation of gastric cancer cells. 2004 Feb 15 1
22 14966868 Responses and signaling pathways in human optic nerve head astrocytes exposed to hydrostatic pressure in vitro. 2004 Mar 1
23 12584173 15-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer. 2003 Feb 2
24 12124863 Cyclooxygenase 2-dependent prostaglandin E2 modulates cartilage proteoglycan degradation in human osteoarthritis explants. 2002 Jul 3
25 10694339 Effective diminution of amniotic prostaglandin production by selective inhibitors of cyclooxygenase type 2. 2000 Feb 1
26 10773022 Inhibition of cyclooxygenase-2 decreases DNA synthesis induced by platelet-derived growth factor in Swiss 3T3 fibroblasts. 2000 May 2
27 11079544 Inhibition of cyclooxygenase-2 protects motor neurons in an organotypic model of amyotrophic lateral sclerosis. 2000 Nov 1