Disulfides

immunglobulin heavy chain variable region ; Homo sapiens







29 Article(s)
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1 33190426 Effects of variable domain orientation on anti-HER2 single-chain variable fragment antibody expressed in the Escherichia coli cytoplasm. 2021 Mar 2
2 33458528 Human Hexa-Histidine-Tagged Single-Chain Variable Fragments for Bioimaging of Bacterial Infections. 2021 Jan 12 1
3 31691197 Anti-HER2 scFv Expression in Escherichia coli SHuffle®T7 Express Cells: Effects on Solubility and Biological Activity. 2020 Jan 2
4 31181988 Development of tibulizumab, a tetravalent bispecific antibody targeting BAFF and IL-17A for the treatment of autoimmune disease. 2019 Aug/Sep 1
5 30130449 Characterization and analysis of scFv-IgG bispecific antibody size variants. 2018 Nov-Dec 5
6 28340507 Understanding the contribution of disulfide bridges to the folding and misfolding of an anti-Aβ scFv. 2017 Jun 2
7 28423625 Inhibition activity of a disulfide-stabilized diabody against basic fibroblast growth factor in lung cancer. 2017 Mar 21 1
8 24895182 Structural design of disialoganglioside GD2 and CD3-bispecific antibodies to redirect T cells for tumor therapy. 2015 Jan 15 1
9 25523746 Nanocell targeting using engineered bispecific antibodies. 2015 1
10 25256416 Co-expression of Dsb proteins enables soluble expression of a single-chain variable fragment (scFv) against human type 1 insulin-like growth factor receptor (IGF-1R) in E. coli. 2014 Dec 1
11 25478966 Anti-CTGF single-chain variable fragment dimers inhibit human airway smooth muscle (ASM) cell proliferation by down-regulating p-Akt and p-mTOR levels. 2014 3
12 22138455 Intranuclear delivery of a novel antibody-derived radiosensitizer targeting the DNA-dependent protein kinase catalytic subunit. 2012 Jul 1 1
13 22464987 Development of tetravalent IgG1 dual targeting IGF-1R-EGFR antibodies with potent tumor inhibition. 2012 Oct 15 1
14 22484084 A novel disulfide-stabilized single-chain variable antibody fragment against rabies virus G protein with enhanced in vivo neutralizing potency. 2012 Jun 1
15 22907349 Selection of stable scFv antibodies by phage display. 2012 1
16 20019028 A modular IgG-scFv bispecific antibody topology. 2010 Apr 3
17 20068035 Engineering anti-vascular endothelial growth factor single chain disulfide-stabilized antibody variable fragments (sc-dsFv) with phage-displayed sc-dsFv libraries. 2010 Mar 12 1
18 20424732 Signal sequence as a determinant in expressing disulfide-stabilized single chain antibody variable fragments (sc-dsFv) against human VEGF. 2010 Jul 1
19 21339972 Stabilization of the single-chain fragment variable by an interdomain disulfide bond and its effect on antibody affinity. 2010 Dec 23 3
20 19099209 Construction, purification, and characterization of anti-BAFF scFv-Fc fusion antibody expressed in CHO/dhfr- cells. 2009 Jun 1
21 18795288 High-level expression and characterization of an anti-VEGF165 single-chain variable fragment (scFv) by small ubiquitin-related modifier fusion in Escherichia coli. 2008 Nov 1
22 12831531 Minimal structural elements of an inhibitory anti-ATF1/CREB single-chain antibody fragment (scFv41.4). 2003 Apr 1
23 11105248 Efficient heterodimerization of recombinant bi- and trispecific antibodies. 2000 1
24 11120833 Fab chains as an efficient heterodimerization scaffold for the production of recombinant bispecific and trispecific antibody derivatives. 2000 Dec 15 2
25 10390351 Removal of the conserved disulfide bridges from the scFv fragment of an antibody: effects on folding kinetics and aggregation. 1999 Jul 9 2
26 9637257 An intrinsically stable antibody scFv fragment can tolerate the loss of both disulfide bonds and fold correctly. 1998 May 15 8
27 9761676 The nature of antibody heavy chain residue H6 strongly influences the stability of a VH domain lacking the disulfide bridge. 1998 1
28 9026037 Optimization of conditions for formation and analysis of anti-CD19 FVS191 single-chain Fv homodimer (scFv')2. 1997 Jan-Feb 1
29 9404661 Generation and characterization of an anti-CD19 single-chain Fv immunotoxin composed of C-terminal disulfide-linked dgRTA. 1997 Nov-Dec 3