Sulfhydryl Compounds

kelch like ECH associated protein 1 ; Homo sapiens







38 Article(s)
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1 33428920 Effect of combined exposure to environmental aliphatic electrophiles from plants on Keap1/Nrf2 activation and cytotoxicity in HepG2 cells: A model of an electrophile exposome. 2021 Feb 15 2
2 34943032 The KEAP1-NRF2 System in Healthy Aging and Longevity. 2021 Nov 30 1
3 30961461 Bioavailability of naringenin chalcone in humans after ingestion of cherry tomatoes. 2020 Oct 1
4 31302696 Understanding the role of the cytoprotective transcription factor nuclear factor erythroid 2-related factor 2-lessons from evolution, the animal kingdom and rare progeroid syndromes. 2020 Dec 4 1
5 31518425 From germ cells to neonates: the beginning of life and the KEAP1-NRF2 system. 2020 Feb 1 1
6 32416464 Possible differences in the mechanism of malignant transformation of HaCaT cells by arsenite and its dimethyl metabolites, particularly dimethylthioarsenics. 2020 May 6 1
7 30587509 Identification of Novel Protein Targets of Dimethyl Fumarate Modification in Neurons and Astrocytes Reveals Actions Independent of Nrf2 Stabilization. 2019 Mar 1
8 31132430 NRF2 antioxidant response protects against acidic bile salts-induced oxidative stress and DNA damage in esophageal cells. 2019 Aug 28 1
9 29423025 Methylseleninic acid induces NAD(P)H:quinone oxidoreductase-1 expression through activation of NF-E2-related factor 2 in Chang liver cells. 2018 Jan 9 1
10 29717933 The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis. 2018 Jul 1 2
11 29898414 Is it worth expending energy to convert biliverdin into bilirubin? 2018 Aug 20 2
12 28126440 Activation of anti-oxidant Nrf2 signaling by substituted trans stilbenes. 2017 Feb 15 1
13 28441057 Oxidative Stress. 2017 Jun 20 1
14 28473247 Oxidized 5-aminosalicylic acid activates Nrf2-HO-1 pathway by covalently binding to Keap1: Implication in anti-inflammatory actions of 5-aminosalicylic acid. 2017 Jul 1
15 28123399 The status of Nrf2-based therapeutics: current perspectives and future prospects. 2016 Nov 2
16 25813625 Heme oxygenase-1 determines the differential response of breast cancer and normal cells to piperlongumine. 2015 Apr 2
17 26122708 Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease. 2015 Nov 2
18 26205490 KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity. 2015 Aug 1 2
19 25364233 Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties. 2014 1
20 23339572 Chemical reactivity and biological activity of chalcones and other α,β-unsaturated carbonyl compounds. 2013 Aug 2
21 23581983 Keap1-Nrf2 signaling pathway: mechanisms of regulation and role in protection of cells against toxicity caused by xenobiotics and electrophiles. 2013 Feb 1
22 23719925 Convenient method to assess chemical modification of protein thiols by electrophilic metals. 2013 1
23 24323934 [Roles of metabolic compartmentalization by astrocytes and neurons in the pathophysiology and treatment of Parkinson's disease]. 2013 Dec 1
24 22558124 Mechanism of chemical activation of Nrf2. 2012 2
25 21793854 Regulation of the Keap1/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modifications. 2011 Jul 1
26 22118669 HSF1-dependent upregulation of Hsp70 by sulfhydryl-reactive inducers of the KEAP1/NRF2/ARE pathway. 2011 Nov 23 1
27 20026152 Activation of the Nrf2/ARE pathway via S-alkylation of cysteine 151 in the chemopreventive agent-sensor Keap1 protein by falcarindiol, a conjugated diacetylene compound. 2010 Apr 1 1
28 20655236 Inactivation of protein tyrosine phosphatases by oltipraz and other cancer chemopreventive 1,2-dithiole-3-thiones. 2010 Aug 15 1
29 19161347 The permissive role of mitochondria in the induction of haem oxygenase-1 in endothelial cells. 2009 Apr 15 2
30 19743802 Catechol type polyphenol is a potential modifier of protein sulfhydryls: development and application of a new probe for understanding the dietary polyphenol actions. 2009 Oct 1
31 19786557 NRF2 cysteine residues are critical for oxidant/electrophile-sensing, Kelch-like ECH-associated protein-1-dependent ubiquitination-proteasomal degradation, and transcription activation. 2009 Dec 3
32 18062931 Keap1 modification and nuclear accumulation in response to S-nitrosocysteine. 2008 Feb 15 2
33 18458837 The cancer chemopreventive actions of phytochemicals derived from glucosinolates. 2008 May 2
34 16407140 Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophilic [correction of electrophillic] phase II inducers. 2006 Jan 17 1
35 17046835 PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex. 2006 Dec 8 1
36 15985429 Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation. 2005 Sep 9 1
37 14616092 Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products. 2004 Mar 1 3
38 14500406 NADPH oxidase activity is essential for Keap1/Nrf2-mediated induction of GCLC in response to 2-indol-3-yl-methylenequinuclidin-3-ols. 2003 Sep 1 2