| 1 |
35204126 | Oxidative Stress-Induced Misfolding and Inclusion Formation of Nrf2 and Keap1. | 2022 Jan 27 |
1 |
| 2 |
35306364 | Characterization of the modification of Kelch-like ECH-associated protein 1 by different fumarates. | 2022 May 21 |
2 |
| 3 |
35550920 | Developing dietary curcumin mono-carbonyl piperidinone analogs as Nrf2-dependent cytoprotectors against oxidative damage: Structure-activity relationship and mechanisms. | 2022 Jun |
2 |
| 4 |
32672401 | Structural insights into the multiple binding modes of Dimethyl Fumarate (DMF) and its analogs to the Kelch domain of Keap1. | 2021 Mar |
1 |
| 5 |
33298526 | Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production. | 2021 Jan-Jun |
2 |
| 6 |
33530504 | Activation of NRF2 and ATF4 Signaling by the Pro-Glutathione Molecule I-152, a Co-Drug of N-Acetyl-Cysteine and Cysteamine. | 2021 Jan 26 |
1 |
| 7 |
33775773 | Activation of anti-oxidant Keap1/Nrf2 pathway modulates efficacy of dihydroartemisinin-based monotherapy and combinatory therapy with ionizing radiation. | 2021 May 20 |
1 |
| 8 |
33801446 | Fighting Oxidative Stress with Sulfur: Hydrogen Sulfide in the Renal and Cardiovascular Systems. | 2021 Mar 2 |
1 |
| 9 |
33819622 | Kinetic assessment of Michael addition reactions of alpha, beta-unsaturated carbonyl compounds to amino acid and protein thiols. | 2021 Jun |
1 |
| 10 |
34012501 | The Keap1-Nrf2 System: A Mediator between Oxidative Stress and Aging. | 2021 |
2 |
| 11 |
34502501 | An Overview of the Nrf2/ARE Pathway and Its Role in Neurodegenerative Diseases. | 2021 Sep 4 |
2 |
| 12 |
34626892 | Non-canonical Keap1-independent activation of Nrf2 in astrocytes by mild oxidative stress. | 2021 Nov |
2 |
| 13 |
34774851 | Up-regulation of Nrf2/P62/Keap1 involves in the anti-fibrotic effect of combination of monoammonium glycyrrhizinate and cysteine hydrochloride induced by CCl4. | 2021 Dec 15 |
1 |
| 14 |
34828261 | A Quantitative Proteomics Approach to Gain Insight into NRF2-KEAP1 Skeletal Muscle System and Its Cysteine Redox Regulation. | 2021 Oct 21 |
1 |
| 15 |
34943032 | The KEAP1-NRF2 System in Healthy Aging and Longevity. | 2021 Nov 30 |
1 |
| 16 |
31367013 | SLC27A5 deficiency activates NRF2/TXNRD1 pathway by increased lipid peroxidation in HCC. | 2020 Mar |
2 |
| 17 |
31518425 | From germ cells to neonates: the beginning of life and the KEAP1-NRF2 system. | 2020 Feb 1 |
1 |
| 18 |
31883977 | Fumarate and oxidative stress synergize to promote stability of C/EBP homologous protein in the adipocyte. | 2020 Feb 20 |
1 |
| 19 |
32053878 | Electrophiles Against (Skin) Diseases: More Than Nrf2. | 2020 Feb 11 |
2 |
| 20 |
32284348 | The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway. | 2020 Jun 15 |
1 |
| 21 |
32302104 | 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. | 2020 May 13 |
1 |
| 22 |
32574549 | KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease. | 2020 Jun |
3 |
| 23 |
32787104 | CDDO-imidazolide Targets Multiple Amino Acid Residues on the Nrf2 Adaptor, Keap1. | 2020 Sep 10 |
1 |
| 24 |
33182676 | Electrophile Modulation of Inflammation: A Two-Hit Approach. | 2020 Nov 10 |
1 |
| 25 |
30610225 | Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases. | 2019 Apr |
1 |
| 26 |
30793592 | Measuring the Interaction of Transcription Factor Nrf2 with Its Negative Regulator Keap1 in Single Live Cells by an Improved FRET/FLIM Analysis. | 2019 Mar 18 |
2 |
| 27 |
31132430 | NRF2 antioxidant response protects against acidic bile salts-induced oxidative stress and DNA damage in esophageal cells. | 2019 Aug 28 |
3 |
| 28 |
31332308 | S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate. | 2019 Oct |
1 |
| 29 |
31402317 | Non-covalent NRF2 Activation Confers Greater Cellular Protection than Covalent Activation. | 2019 Oct 17 |
2 |
| 30 |
31737667 | Keap1 Cystenine 151 as a Potential Target for Artemisitene-Induced Nrf2 Activation. | 2019 |
4 |
| 31 |
29423025 | Methylseleninic acid induces NAD(P)H:quinone oxidoreductase-1 expression through activation of NF-E2-related factor 2 in Chang liver cells. | 2018 Jan 9 |
1 |
| 32 |
29590092 | Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. | 2018 Apr 5 |
1 |
| 33 |
29717933 | The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis. | 2018 Jul 1 |
1 |
| 34 |
29795117 | C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape. | 2018 May 23 |
4 |
| 35 |
29913224 | Canonical and non-canonical mechanisms of Nrf2 activation. | 2018 Aug |
1 |
| 36 |
30037040 | The Keap1/Nrf2-ARE Pathway as a Pharmacological Target for Chalcones. | 2018 Jul 20 |
3 |
| 37 |
30053409 | Hydroxytyrosol butyrate inhibits 6-OHDA-induced apoptosis through activation of the Nrf2/HO-1 axis in SH-SY5Y cells. | 2018 Sep 5 |
2 |
| 38 |
30261176 | Zinc-binding triggers a conformational-switch in the cullin-3 substrate adaptor protein KEAP1 that controls transcription factor NRF2. | 2018 Dec 1 |
4 |
| 39 |
30323285 | A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling. | 2018 Oct |
2 |
| 40 |
30442144 | Four-octyl itaconate activates Keap1-Nrf2 signaling to protect neuronal cells from hydrogen peroxide. | 2018 Nov 15 |
1 |
| 41 |
30466076 | 4-Octyl Itaconate Activates Nrf2 Signaling to Inhibit Pro-Inflammatory Cytokine Production in Peripheral Blood Mononuclear Cells of Systemic Lupus Erythematosus Patients. | 2018 |
2 |
| 42 |
27497696 | Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants. | 2017 Mar 1 |
5 |
| 43 |
28126440 | Activation of anti-oxidant Nrf2 signaling by substituted trans stilbenes. | 2017 Feb 15 |
3 |
| 44 |
28186440 | Britanin Ameliorates Cerebral Ischemia-Reperfusion Injury by Inducing the Nrf2 Protective Pathway. | 2017 Oct 10 |
2 |
| 45 |
28202606 | Retraction: Antioxidant-induced modification of INrf2 cysteine 151 and PKC-δ-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance. | 2017 Feb 15 |
1 |
| 46 |
28286015 | Rutin protects against H2O2-triggered impaired relaxation of placental arterioles and induces Nrf2-mediated adaptation in Human Umbilical Vein Endothelial Cells exposed to oxidative stress. | 2017 May |
1 |
| 47 |
28604588 | Docosahexaenoic Acid Induces Expression of Heme Oxygenase-1 and NAD(P)H:quinone Oxidoreductase through Activation of Nrf2 in Human Mammary Epithelial Cells. | 2017 Jun 10 |
2 |
| 48 |
28965760 | Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer. | 2017 Oct 19 |
1 |
| 49 |
29053012 | The ratio of thioredoxin/Keap1 protein level is a predictor of distant metastasis in colorectal cancer. | 2017 Dec |
1 |
| 50 |
26489878 | Engineering a genetically encoded competitive inhibitor of the KEAP1-NRF2 interaction via structure-based design and phage display. | 2016 Jan |
1 |