| 1 |
34866036 | Effects of the MDM2 inhibitor Nutlin-3a on sensitivity of pancreatic cancer cells to berberine and modified berberines in the presence and absence of WT-TP53. | 2022 Jan |
1 |
| 2 |
35179215 | Targeting the TP53/MDM2 axis enhances radiation sensitivity in atypical teratoid rhabdoid tumors. | 2022 Mar |
2 |
| 3 |
35410287 | Single-cell analysis of p53 transitional dynamics unravels stimulus- and cell type-dependent signaling output motifs. | 2022 Apr 11 |
1 |
| 4 |
35429966 | Therapeutic synergy of Triptolide and MDM2 inhibitor against acute myeloid leukemia through modulation of p53-dependent and -independent pathways. | 2022 Apr 16 |
1 |
| 5 |
33262524 | miR-10a as a therapeutic target and predictive biomarker for MDM2 inhibition in acute myeloid leukemia. | 2021 Jul |
1 |
| 6 |
33303573 | Nutlin-3a Enhances Natural Killer Cell-Mediated Killing of Neuroblastoma by Restoring p53-Dependent Expression of Ligands for NKG2D and DNAM-1 Receptors. | 2021 Feb |
1 |
| 7 |
33433933 | p53-mediated regulation of mitochondrial dynamics plays a pivotal role in the senescence of various normal cells as well as cancer cells. | 2021 Feb |
1 |
| 8 |
33917342 | Pharmacological Inhibition of WIP1 Sensitizes Acute Myeloid Leukemia Cells to the MDM2 Inhibitor Nutlin-3a. | 2021 Apr 6 |
1 |
| 9 |
34287267 | Overcoming of Microenvironment Protection on Primary Chronic Lymphocytic Leukemia Cells after Treatment with BTK and MDM2 Pharmacological Inhibitors. | 2021 Jul 1 |
1 |
| 10 |
34485982 | Activation of P53 Via Nutlin-3a Reveals Role for P53 In ROS Signaling During Cardiac Differentiation of hiPSCs. | 2021 |
1 |
| 11 |
31767563 | Detection of Circulating and Disseminated Neuroblastoma Cells Using the ImageStream Flow Cytometer for Use as Predictive and Pharmacodynamic Biomarkers. | 2020 Jan 1 |
1 |
| 12 |
31774938 | Optimized Inhibitors of MDM2 via an Attempted Protein-Templated Reductive Amination. | 2020 Feb 17 |
1 |
| 13 |
31866490 | CDK9 inhibitors reactivate p53 by downregulating iASPP. | 2020 Mar |
1 |
| 14 |
31918545 | Discovery of Nonpeptide, Environmentally Sensitive Fluorescent Probes for Imaging p53-MDM2 Interactions in Living Cell Lines and Tissue Slice. | 2020 Feb 4 |
2 |
| 15 |
32063580 | Cisplatin in Combination with MDM2 Inhibition Downregulates Rad51 Recombinase in a Bimodal Manner to Inhibit Homologous Recombination and Augment Tumor Cell Kill. | 2020 Apr |
1 |
| 16 |
32615946 | Synergisms of genome and metabolism stabilizing antitumor therapy (GMSAT) in human breast and colon cancer cell lines: a novel approach to screen for synergism. | 2020 Jul 2 |
1 |
| 17 |
32800832 | F-box protein FBXO31 modulates apoptosis and epithelial-mesenchymal transition of cervical cancer via inactivation of the PI3K/AKT-mediated MDM2/p53 axis. | 2020 Oct 15 |
1 |
| 18 |
32874188 | The MDM2 ligand Nutlin-3 differentially alters expression of the immune blockade receptors PD-L1 and CD276. | 2020 |
1 |
| 19 |
32934219 | CDK9 activity is critical for maintaining MDM4 overexpression in tumor cells. | 2020 Sep 15 |
1 |
| 20 |
30966857 | Comparison of genotoxic versus nongenotoxic stabilization of p53 provides insight into parallel stress-responsive transcriptional networks. | 2019 Apr |
1 |
| 21 |
31134974 | Dual-channel surface plasmon resonance monitoring of intracellular levels of the p53-MDM2 complex and caspase-3 induced by MDM2 antagonist Nutlin-3. | 2019 Jul 7 |
2 |
| 22 |
31502598 | Real-time surface plasmon resonance monitoring of site-specific phosphorylation of p53 protein and its interaction with MDM2 protein. | 2019 Oct 21 |
1 |
| 23 |
31720601 | The hydrophobically-tagged MDM2-p53 interaction inhibitor Nutlin-3a-HT is more potent against tumor cells than Nutlin-3a. | 2019 Nov 26 |
3 |
| 24 |
29394130 | DZNep represses Bcl-2 expression and modulates apoptosis sensitivity in response to Nutlin-3a. | 2018 Jun 3 |
1 |
| 25 |
29532999 | Nutlin-3a as a novel anticancer agent for adrenocortical carcinoma with CTNNB1 mutation. | 2018 Apr |
1 |
| 26 |
29737431 | Mycoplasma hyorhinis reduces sensitivity of human lung carcinoma cells to Nutlin-3 and promotes their malignant phenotype. | 2018 Jul |
1 |
| 27 |
29980405 | Introduction of WT-TP53 into pancreatic cancer cells alters sensitivity to chemotherapeutic drugs, targeted therapeutics and nutraceuticals. | 2018 Aug |
1 |
| 28 |
30355102 | Single-Nucleotide Polymorphism 309T>G in the MDM2 Promoter Determines Functional Outcome After Stroke. | 2018 Oct |
1 |
| 29 |
27813088 | Nutlin-3a selects for cells harbouring TP53 mutations. | 2017 Feb 15 |
1 |
| 30 |
28155209 | Do Mesenchymal Stem Cells Derived From Atypical Lipomatous Tumors Have Greater Differentiation Potency Than Cells From Normal Adipose Tissues? | 2017 Jun |
2 |
| 31 |
26556313 | Spiro-oxindole derivative 5-chloro-4',5'-diphenyl-3'-(4-(2-(piperidin-1-yl) ethoxy) benzoyl) spiro[indoline-3,2'-pyrrolidin]-2-one triggers apoptosis in breast cancer cells via restoration of p53 function. | 2016 Jan |
2 |
| 32 |
26883108 | Inhibition of WIP1 phosphatase sensitizes breast cancer cells to genotoxic stress and to MDM2 antagonist nutlin-3. | 2016 Mar 22 |
1 |
| 33 |
27038437 | Probing the Small-Molecule Inhibition of an Anticancer Therapeutic Protein-Protein Interaction Using a Solid-State Nanopore. | 2016 May 4 |
4 |
| 34 |
27129163 | Downregulation of cyclin D1 sensitizes cancer cells to MDM2 antagonist Nutlin-3. | 2016 May 31 |
1 |
| 35 |
27283770 | Inhibition of histone deacetylases induces formation of multipolar spindles and subsequent p53-dependent apoptosis in nasopharyngeal carcinoma cells. | 2016 Jul 12 |
1 |
| 36 |
27626308 | The pathophysiological significance of PPM1D and therapeutic targeting of PPM1D-mediated signaling by GSK2830371 in mantle cell lymphoma. | 2016 Oct 25 |
1 |
| 37 |
25482373 | Human mediator MED17 subunit plays essential roles in gene regulation by associating with the transcription and DNA repair machineries. | 2015 Mar |
1 |
| 38 |
25483068 | ATM regulates cell fate choice upon p53 activation by modulating mitochondrial turnover and ROS levels. | 2015 |
1 |
| 39 |
26350565 | The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast cancer cells. | 2015 Dec |
1 |
| 40 |
26431163 | Mdm2 inhibition confers protection of p53-proficient cells from the cytotoxic effects of Wee1 inhibitors. | 2015 Oct 20 |
1 |
| 41 |
24268795 | Synthesis and evaluation of spiroisoxazoline oxindoles as anticancer agents. | 2014 Jan 1 |
1 |
| 42 |
24286312 | Nutlin-3 downregulates p53 phosphorylation on serine392 and induces apoptosis in hepatocellular carcinoma cells. | 2014 Apr |
1 |
| 43 |
24356969 | Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. | 2014 Feb 7 |
1 |
| 44 |
24473562 | Upregulation of SOCS-1 by Nutlin-3 in acute myeloid leukemia cells but not in primary normal cells. | 2014 Jan |
1 |
| 45 |
24522962 | Inhibitors of the p53-Mdm2 interaction increase programmed cell death and produce abnormal phenotypes in the placozoon Trichoplax adhaerens (F.E. Schulze). | 2014 Mar |
1 |
| 46 |
24659749 | High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia. | 2014 Feb 28 |
1 |
| 47 |
24921920 | Structurally diverse MDM2-p53 antagonists act as modulators of MDR-1 function in neuroblastoma. | 2014 Aug 12 |
1 |
| 48 |
25214240 | Epibrassinolide-induced apoptosis regardless of p53 expression via activating polyamine catabolic machinery, a common target for androgen sensitive and insensitive prostate cancer cells. | 2014 Dec |
1 |
| 49 |
25382556 | Human mediator subunit MED15 promotes transcriptional activation. | 2014 Oct |
1 |
| 50 |
22469985 | Kaposi's sarcoma herpesvirus lytic replication compromises apoptotic response to p53 reactivation in virus-induced lymphomas. | 2013 Feb 28 |
1 |