Serine

synuclein, alpha ; Mus musculus







43 Article(s)
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1 35606853 Analysis of hemisphere-dependent effects of unilateral intrastriatal injection of α-synuclein pre-formed fibrils on mitochondrial protein levels, dynamics, and function. 2022 May 23 1
2 33361597 Behavioral Deficits and Brain α-Synuclein and Phosphorylated Serine-129 α-Synuclein in Male and Female Mice Overexpressing Human α-Synuclein. 2021 4
3 33428941 Genetic deletion of Polo-like kinase 2 reduces alpha-synuclein serine-129 phosphorylation in presynaptic terminals but not Lewy bodies. 2021 Jan-Jun 1
4 34136810 Prodromal neuroinvasion of pathological α-synuclein in brainstem reticular nuclei and white matter lesions in a model of α-synucleinopathy. 2021 3
5 34172566 Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease. 2021 Jun 29 2
6 34218047 Preformed fibrils generated from mouse alpha-synuclein produce more inclusion pathology in rats than fibrils generated from rat alpha-synuclein. 2021 Aug 1
7 34595918 Accumulation of Prion and Abnormal Prion Protein Induces Hyperphosphorylation of α-Synuclein in the Brain Tissues from Prion Diseases and in the Cultured Cells. 2021 Oct 20 2
8 31881179 p38 MAPK-DRP1 signaling is involved in mitochondrial dysfunction and cell death in mutant A53T α-synuclein model of Parkinson's disease. 2020 Feb 1 1
9 31893437 Acupuncture Inhibits the Increase in Alpha-Synuclein in Substantia Nigra in an MPTP- Induced Parkinsonism Mouse Model. 2020 1
10 32210174 Fatty Acid Binding Protein 3 Enhances the Spreading and Toxicity of α-Synuclein in Mouse Brain. 2020 Mar 23 3
11 32343709 S-Nitrosylation of G protein-coupled receptor kinase 6 and Casein kinase 2 alpha modulates their kinase activity toward alpha-synuclein phosphorylation in an animal model of Parkinson's disease. 2020 1
12 32678959 IL-1β/IL-1R1 signaling induced by intranasal lipopolysaccharide infusion regulates alpha-Synuclein pathology in the olfactory bulb, substantia nigra and striatum. 2020 Nov 1
13 32716318 Modeling α-Synucleinopathy in Organotypic Brain Slice Culture with Preformed α-Synuclein Amyloid Fibrils. 2020 1
14 32768884 Papaverine inhibits α-synuclein aggregation by modulating neuroinflammation and matrix metalloproteinase-3 expression in the subacute MPTP/P mouse model of Parkinson's disease. 2020 Oct 2
15 30718039 MicroRNA-26a/Death-Associated Protein Kinase 1 Signaling Induces Synucleinopathy and Dopaminergic Neuron Degeneration in Parkinson's Disease. 2019 May 1 1
16 31205308 Generation of Alpha-Synuclein Preformed Fibrils from Monomers and Use In Vivo. 2019 Jun 2 1
17 31255487 Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease. 2019 Aug 21 2
18 31358782 Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders. 2019 Jul 29 1
19 29196214 The lysosomal enzyme alpha-Galactosidase A is deficient in Parkinson's disease brain in association with the pathologic accumulation of alpha-synuclein. 2018 Feb 2
20 29888794 Sensitivity and specificity of phospho-Ser129 α-synuclein monoclonal antibodies. 2018 Aug 15 1
21 29899409 Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T α-synuclein model of Parkinson's disease. 2018 Jun 13 1
22 29950985 Leucine Carboxyl Methyltransferase Downregulation and Protein Phosphatase Methylesterase Upregulation Contribute Toward the Inhibition of Protein Phosphatase 2A by α-Synuclein. 2018 2
23 29988485 Age-dependent alpha-synuclein accumulation and aggregation in the colon of a transgenic mouse model of Parkinson's disease. 2018 1
24 28924920 Age-Dependent Alpha-Synuclein Accumulation and Phosphorylation in the Enteric Nervous System in a Transgenic Mouse Model of Parkinson's Disease. 2017 Oct 1
25 29040593 Oral Exposure to Paraquat Triggers Earlier Expression of Phosphorylated α-Synuclein in the Enteric Nervous System of A53T Mutant Human α-Synuclein Transgenic Mice. 2017 Dec 1 1
26 29184069 Phosphorylated exogenous alpha-synuclein fibrils exacerbate pathology and induce neuronal dysfunction in mice. 2017 Nov 28 3
27 27358461 Poststroke Induction of α-Synuclein Mediates Ischemic Brain Damage. 2016 Jun 29 1
28 26099628 Nigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration. 2015 Jun 23 1
29 24128992 In vivo modulation of polo-like kinases supports a key role for PLK2 in Ser129 α-synuclein phosphorylation in mouse brain. 2014 Jan 3 1
30 24486885 Transgenic mice expressing S129 phosphorylation mutations in α-synuclein. 2014 Mar 20 1
31 24898698 Progression of intestinal permeability changes and alpha-synuclein expression in a mouse model of Parkinson's disease. 2014 Jul 1
32 25037286 Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice. 2014 Nov 1
33 22326202 Lewy-like aggregation of α-synuclein reduces protein phosphatase 2A activity in vitro and in vivo. 2012 Apr 5 5
34 23209687 Impaired c-Fos and polo-like kinase 2 induction in the limbic system of fear-conditioned α-synuclein transgenic mice. 2012 2
35 21127069 Parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and alpha-synuclein mutations promote Tau protein phosphorylation at Ser262 and destabilize microtubule cytoskeleton in vitro. 2011 Feb 18 1
36 21562258 Enhanced phosphatase activity attenuates α-synucleinopathy in a mouse model. 2011 May 11 2
37 21849493 Effect of Ser-129 phosphorylation on interaction of α-synuclein with synaptic and cellular membranes. 2011 Oct 14 3
38 19852948 G protein-coupled receptor kinase 5, overexpressed in the alpha-synuclein up-regulation model of Parkinson's disease, regulates bcl-2 expression. 2010 Jan 11 1
39 20356833 Serine 129 phosphorylation reduces the ability of alpha-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo. 2010 Jun 4 9
40 19004816 Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system. 2009 Jan 30 5
41 19272424 Nuclear and neuritic distribution of serine-129 phosphorylated alpha-synuclein in transgenic mice. 2009 Jun 2 2
42 19680561 Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy. 2009 Aug 14 2
43 17360705 Assembly of lysine 63-linked ubiquitin conjugates by phosphorylated alpha-synuclein implies Lewy body biogenesis. 2007 May 11 3