Arsenic Trioxide

mitogen-activated protein kinase 3 ; Homo sapiens







14 Article(s)
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1 26459009 Downregulation of P-gp, Ras and p-ERK1/2 contributes to the arsenic trioxide-induced reduction in drug resistance towards doxorubicin in gastric cancer cell lines. 2015 Nov 3
2 23253724 Arsenic trioxide regulates the production and activities of matrix metalloproteinases-1, -2, and -9 in fibroblasts and THP-1. 2012 Dec 2
3 20799280 Arsenic trioxide induces apoptosis through JNK and ERK in human mesothelioma cells. 2011 Mar 3
4 20074581 Blockage of JNK pathway enhances arsenic trioxide-induced apoptosis in human keratinocytes. 2010 Apr 15 2
5 20164150 The expression of p38, ERK1 and Bax proteins has increased during the treatment of newly diagnosed acute promyelocytic leukemia with arsenic trioxide. 2010 Sep 1
6 20862710 Activation of the p38 MAPK/Akt/ERK1/2 signal pathways is required for the protein stabilization of CDC6 and cyclin D1 in low-dose arsenite-induced cell proliferation. 2010 Dec 15 3
7 19060284 Antitumor activity of arsenic trioxide on retinoblastoma: cell differentiation and apoptosis depending on arsenic trioxide concentration. 2009 Apr 2
8 19242099 Combination treatment with arsenic trioxide and irradiation enhances autophagic effects in U118-MG cells through increased mitotic arrest and regulation of PI3K/Akt and ERK1/2 signaling pathways. 2009 May 1
9 18210215 Inhibitory role of TGIF in the As2O3-regulated p21 WAF1/CIP1 expression. 2008 May 1
10 18822310 Arsenic trioxide phosphorylates c-Fos to transactivate p21(WAF1/CIP1) expression. 2008 Dec 1 3
11 19088370 Arsenic trioxide (As2O3) inhibits expression of estrogen receptor-alpha through regulation of the mitogen-activated protein kinase (MAPK) pathway in endometrial cancer cells. 2008 Dec 1
12 16283431 Opposite effect of ERK1/2 and JNK on p53-independent p21WAF1/CIP1 activation involved in the arsenic trioxide-induced human epidermoid carcinoma A431 cellular cytotoxicity. 2006 Jan 2
13 15538402 Arsenic trioxide (ATO) and MEK1 inhibition synergize to induce apoptosis in acute promyelocytic leukemia cells. 2005 Feb 3
14 11304686 Apoptosis induced by arsenic trioxide in leukemia U937 cells is dependent on activation of p38, inactivation of ERK and the Ca2+-dependent production of superoxide. 2001 May 15 2