Acetylcysteine

mitogen-activated protein kinase 3 ; Homo sapiens







53 Article(s)
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1 31724279 p,p'-Dichlorodiphenyltrichloroethane promotes aerobic glycolysis via reactive oxygen species-mediated extracellular signal-regulated kinase/M2 isoform of pyruvate kinase (PKM2) signaling in colorectal cancer cells. 2020 Mar 1
2 28583366 Pentoxifylline induces apoptosis of HepG2 cells by reducing reactive oxygen species production and activating the MAPK signaling. 2017 Aug 15 1
3 26111538 MWCNTs Induce ROS Generation, ERK Phosphorylation, and SOD-2 Expression in Human Mesothelial Cells. 2016 Jan-Feb 1
4 26906511 Folic Acid Attenuates Vascular Endothelial Cell Injury Caused by Hypoxia via the Inhibition of ERK1/2/NOX4/ROS Pathway. 2016 Jun 1
5 27484511 Aromatic heterocyclic esters of podophyllotoxin exert anti-MDR activity in human leukemia K562/ADR cells via ROS/MAPK signaling pathways. 2016 Nov 10 1
6 27620528 4-Hydroxy-2-nonenal induces apoptosis by activating ERK1/2 signaling and depleting intracellular glutathione in intestinal epithelial cells. 2016 Sep 13 1
7 27687768 Angiotensin-(1-7) abrogates angiotensin II-induced proliferation, migration and inflammation in VSMCs through inactivation of ROS-mediated PI3K/Akt and MAPK/ERK signaling pathways. 2016 Sep 30 2
8 27698876 Eupatilin induces human renal cancer cell apoptosis via ROS-mediated MAPK and PI3K/AKT signaling pathways. 2016 Oct 1
9 27868128 The role of STIM1 in the Cr(vi)-induced [Ca2+]i increase and cell injury in L-02 hepatocytes. 2016 Dec 7 2
10 25697727 Cigarette smoke exposure reveals a novel role for the MEK/ERK1/2 MAPK pathway in regulation of CFTR. 2015 Jun 1
11 25998312 Cadmium Induced Apoptosis in MG63 Cells by Increasing ROS, Activation of p38 MAPK and Inhibition of ERK 1/2 Pathways. 2015 2
12 26149761 Silver nanoparticles-induced cytotoxicity requires ERK activation in human bladder carcinoma cells. 2015 Sep 17 1
13 26299281 Hydrogen sulfide attenuates doxorubicin-induced cardiotoxicity by inhibiting reactive oxygen species-activated extracellular signal-regulated kinase 1/2 in H9c2 cardiac myocytes. 2015 Nov 1
14 26472194 ROS-dependent activation of autophagy is a critical mechanism for the induction of anti-glioma effect of sanguinarine. 2015 Dec 1
15 26484027 Effect of aldosterone on epithelial-to-mesenchymal transition of human peritoneal mesothelial cells. 2015 Jun 1
16 24907397 Hyperglycemia-induced oxidative stress induces apoptosis by inhibiting PI3-kinase/Akt and ERK1/2 MAPK mediated signaling pathway causing downregulation of 8-oxoG-DNA glycosylase levels in glial cells. 2014 Aug 1
17 23363008 Chicoric acid induces apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. 2013 Feb 20 2
18 23405080 Cadmium induces apoptosis in pancreatic β-cells through a mitochondria-dependent pathway: the role of oxidative stress-mediated c-Jun N-terminal kinase activation. 2013 1
19 23416263 Cerium oxide nanoparticles induce cytotoxicity in human hepatoma SMMC-7721 cells via oxidative stress and the activation of MAPK signaling pathways. 2013 Apr 2
20 24021937 Angiotensin II induces C-reactive protein expression via AT1-ROS-MAPK-NF-κB signal pathway in hepatocytes. 2013 1
21 22575515 The inhibitory effects of m-nisoldipine on the 5-hydroxytryptamine-induced proliferation of pulmonary artery smooth muscle cells via Ca2+ antagonism and antioxidant mechanisms. 2012 Jul 5 1
22 22683510 The inhibitory effect of CIL-102 on the growth of human astrocytoma cells is mediated by the generation of reactive oxygen species and induction of ERK1/2 MAPK. 2012 Aug 15 2
23 22946344 Inhibition of cell proliferation and induction of apoptosis by CDDO-Me in pancreatic cancer cells is ROS-dependent. 2012 1
24 21055460 Suppression of human prostate cancer PC-3 cell growth by N-acetylcysteine involves over-expression of Cyr61. 2011 Feb 2
25 21268136 Grape seed extract upregulates p21 (Cip1) through redox-mediated activation of ERK1/2 and posttranscriptional regulation leading to cell cycle arrest in colon carcinoma HT29 cells. 2011 Jul 1
26 19951696 Alpha-eleostearic acid induces autophagy-dependent cell death through targeting AKT/mTOR and ERK1/2 signal together with the generation of reactive oxygen species. 2010 Jan 1 2
27 20570722 Reactive oxygen species as mediators of membrane-dependent signaling induced by ultrafine particles. 2010 Aug 15 1
28 19286926 alpha,beta-Unsaturated aldehydes contained in cigarette smoke elicit IL-8 release in pulmonary cells through mitogen-activated protein kinases. 2009 May 1
29 17967787 Hemin upregulates Egr-1 expression in vascular smooth muscle cells via reactive oxygen species ERK-1/2-Elk-1 and NF-kappaB. 2008 Jan 4 1
30 18252805 The chemopreventive agent curcumin is a potent radiosensitizer of human cervical tumor cells via increased reactive oxygen species production and overactivation of the mitogen-activated protein kinase pathway. 2008 May 1
31 18270969 Redox-regulation of Erk1/2-directed phosphatase by reactive oxygen species: role in signaling TPA-induced growth arrest in ML-1 cells. 2008 Jul 6
32 17503468 Endosulfan decreases cell growth and apoptosis in human HaCaT keratinocytes: partial ROS-dependent ERK1/2 mechanism. 2007 Oct 2
33 17958324 Reactive oxygen species mediate ET-1-induced activation of ERK1/2 signaling in cultured feline esophageal smooth muscle cells. 2007 Sep 1
34 16234311 Redox dependence of glomerular epithelial cell hypertrophy in response to glucose. 2006 Mar 1
35 16543392 Induction of apoptosis in renal cell carcinoma by reactive oxygen species: involvement of extracellular signal-regulated kinase 1/2, p38delta/gamma, cyclooxygenase-2 down-regulation, and translocation of apoptosis-inducing factor. 2006 Jun 1
36 15829704 Albumin activates ERK via EGF receptor in human renal epithelial cells. 2005 May 2
37 15829913 HIV-1 Tat protein-induced alterations of ZO-1 expression are mediated by redox-regulated ERK 1/2 activation. 2005 Oct 2
38 15888667 Effects of organochlorine insecticides on MAP kinase pathways in human HaCaT keratinocytes: key role of reactive oxygen species. 2005 Aug 1
39 16026512 Inhibition of cyclic strain-induced endothelin-1 secretion by tetramethylpyrazine. 2005 Jul 1
40 15027896 Angiotensin II-induced ERK1/ERK2 activation and protein synthesis are redox-dependent in glomerular mesangial cells. 2004 Jul 1 1
41 15203192 Reactive oxygen species mediate Endothelin-1-induced activation of ERK1/2, PKB, and Pyk2 signaling, as well as protein synthesis, in vascular smooth muscle cells. 2004 Jul 15 1
42 15382121 Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes. 2004 Oct 1
43 12406911 Protein kinase Czeta mediated Raf-1/extracellular-regulated kinase activation by daunorubicin. 2003 Feb 15 2
44 12514114 Ferrocene-induced lymphocyte activation and anti-tumor activity is mediated by redox-sensitive signaling. 2003 Mar 1
45 12690112 Heme oxygenase inhibits human airway smooth muscle proliferation via a bilirubin-dependent modulation of ERK1/2 phosphorylation. 2003 Jul 18 1
46 12840032 Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence. 2003 Sep 26 1
47 14516795 Hydrogen peroxide mediates arsenite activation of p70(s6k) and extracellular signal-regulated kinase. 2003 Oct 15 3
48 14623829 Inhibition of cyclic strain-induced endothelin-1 gene expression by resveratrol. 2003 Dec 1
49 14708604 Thiol antioxidants block the activation of antigen-presenting cells by contact sensitizers. 2003 Nov 1
50 11755158 Green tea polyphenols inhibit human vascular smooth muscle cell proliferation stimulated by native low-density lipoprotein. 2002 Jan 2 1