| 1 |
34073791 | Involvement of mTOR Pathways in Recovery from Spinal Cord Injury by Modulation of Autophagy and Immune Response. | 2021 May 24 |
1 |
| 2 |
32062191 | Rapamycin inhibits B-cell activating factor (BAFF)-stimulated cell proliferation and survival by suppressing Ca2+-CaMKII-dependent PTEN/Akt-Erk1/2 signaling pathway in normal and neoplastic B-lymphoid cells. | 2020 May |
1 |
| 3 |
32642408 | RICTOR/mTORC2 affects tumorigenesis and therapeutic efficacy of mTOR inhibitors in esophageal squamous cell carcinoma. | 2020 Jun |
1 |
| 4 |
32990653 | Stimulatory effect of insulin on H+-ATPase in the proximal tubule via the Akt/mTORC2 pathway. | 2020 Oct 17 |
1 |
| 5 |
31081172 | Phosphorylated mTORC1 represses autophagic-related mRNA translation in neurons exposed to ischemia-reperfusion injury. | 2019 Sep |
2 |
| 6 |
31732667 | Combined mTORC1/mTORC2 inhibition blocks growth and induces catastrophic macropinocytosis in cancer cells. | 2019 Dec 3 |
1 |
| 7 |
28300280 | Rapamycin attenuates BAFF-extended proliferation and survival via disruption of mTORC1/2 signaling in normal and neoplastic B-lymphoid cells. | 2018 Jan |
1 |
| 8 |
29080085 | Dual mTORC1/mTORC2 blocker as a possible therapy for tauopathy in cellular model. | 2018 Apr |
1 |
| 9 |
29195143 | Metabolite identification and pharmacokinetic profiling of PP242, an ATP-competitive inhibitor of mTOR using ultra high-performance liquid chromatography and mass spectrometry. | 2018 Jan 1 |
1 |
| 10 |
29344639 | Therapeutic potential of a dual mTORC1/2 inhibitor for the prevention of posterior capsule opacification: An in vitro study. | 2018 Apr |
1 |
| 11 |
29692710 | PP242 Counteracts Glioblastoma Cell Proliferation, Migration, Invasiveness and Stemness Properties by Inhibiting mTORC2/AKT. | 2018 |
1 |
| 12 |
29849119 | mTORC1/2 inhibitor and curcumin induce apoptosis through lysosomal membrane permeabilization-mediated autophagy. | 2018 Sep |
1 |
| 13 |
30300823 | An mTORC1/2 kinase inhibitor enhances the cytotoxicity of gemtuzumab ozogamicin by activation of lysosomal function. | 2018 Nov |
2 |
| 14 |
28402933 | PDK1 inhibitor GSK2334470 exerts antitumor activity in multiple myeloma and forms a novel multitargeted combination with dual mTORC1/C2 inhibitor PP242. | 2017 Jun 13 |
1 |
| 15 |
28679058 | Pharmacological Inhibition of mTOR Kinase Reverses Right Ventricle Remodeling and Improves Right Ventricle Structure and Function in Rats. | 2017 Nov |
2 |
| 16 |
26719046 | ATP-site binding inhibitor effectively targets mTORC1 and mTORC2 complexes in glioblastoma. | 2016 Mar |
2 |
| 17 |
26894601 | Blockage of glutaminolysis enhances the sensitivity of ovarian cancer cells to PI3K/mTOR inhibition involvement of STAT3 signaling. | 2016 Aug |
1 |
| 18 |
27358039 | Inhibition of JNK-mediated autophagy enhances NSCLC cell sensitivity to mTORC1/2 inhibitors. | 2016 Jun 30 |
1 |
| 19 |
25239638 | An mTOR kinase inhibitor slows disease progression in a rat model of polycystic kidney disease. | 2015 Jan |
1 |
| 20 |
25535978 | The antileukemia roles of PP242 alone or in combination with daunorubicin in acute leukemia. | 2015 Apr |
2 |
| 21 |
25762619 | Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion. | 2015 Mar 30 |
1 |
| 22 |
25814662 | 4E-BPs Control Fat Storage by Regulating the Expression of Egr1 and ATGL. | 2015 Jul 10 |
1 |
| 23 |
26001614 | TNF compromises lysosome acidification and reduces α-synuclein degradation via autophagy in dopaminergic cells. | 2015 Sep |
1 |
| 24 |
26636543 | mTOR kinase inhibitor pp242 causes mitophagy terminated by apoptotic cell death in E1A-Ras transformed cells. | 2015 Dec 29 |
4 |
| 25 |
23147251 | Inhibition of mTORC2 but not mTORC1 up-regulates E-cadherin expression and inhibits cell motility by blocking HIF-2α expression in human renal cell carcinoma. | 2013 May |
2 |
| 26 |
23482748 | Comparative effects of PP242 and rapamycin on mTOR signalling and NOTCH signalling in leukemia cells. | 2013 Mar |
1 |
| 27 |
23838676 | A dual mTORC1 and mTORC2 inhibitor shows antitumor activity in esophageal squamous cell carcinoma cells and sensitizes them to cisplatin. | 2013 Oct |
3 |
| 28 |
23991179 | Combination of mTOR and EGFR kinase inhibitors blocks mTORC1 and mTORC2 kinase activity and suppresses the progression of colorectal carcinoma. | 2013 |
2 |
| 29 |
22241218 | Phosphoinositide 3-kinase/AKT/mTORC1/2 signaling determines sensitivity of Burkitt's lymphoma cells to BH3 mimetics. | 2012 Mar |
1 |
| 30 |
22476852 | Targeting of mTORC2 prevents cell migration and promotes apoptosis in breast cancer. | 2012 Aug |
1 |
| 31 |
22826565 | Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment. | 2012 Sep 27 |
1 |
| 32 |
20227039 | Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E. | 2010 Mar 16 |
1 |