| 1 |
34949833 | The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4+ T cells by preventing ferroptosis. | 2022 Feb |
1 |
| 2 |
32394479 | Role of the Mammalian Target of Rapamycin Pathway in Liver Cancer: From Molecular Genetics to Targeted Therapies. | 2021 Jan |
1 |
| 3 |
34102579 | mTOR pathway and DNA damage response: A therapeutic strategy in cancer therapy. | 2021 Aug |
1 |
| 4 |
34130564 | Cancer cells dysregulate PI3K/AKT/mTOR pathway activation to ensure their survival and proliferation: mimicking them is a smart strategy of gammaherpesviruses. | 2021 Oct |
1 |
| 5 |
34215308 | Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration. | 2021 Jul 2 |
1 |
| 6 |
34695518 | Fisetin-induced PTEN expression reverses cellular senescence by inhibiting the mTORC2-Akt Ser473 phosphorylation pathway in vascular smooth muscle cells. | 2021 Dec |
4 |
| 7 |
32312752 | The mTOR inhibitor manassantin B reveals a crucial role of mTORC2 signaling in Epstein-Barr virus reactivation. | 2020 May 22 |
2 |
| 8 |
32347294 | Small molecule H89 renders the phosphorylation of S6K1 and AKT resistant to mTOR inhibitors. | 2020 May 29 |
1 |
| 9 |
32392211 | Depletion of Ric-8B leads to reduced mTORC2 activity. | 2020 May |
1 |
| 10 |
32899613 | Regulation of mTORC2 Signaling. | 2020 Sep 4 |
1 |
| 11 |
33003310 | Activation of Mechanistic Target of Rapamycin (mTOR) in Human Endothelial Cells Infected with Pathogenic Spotted Fever Group Rickettsiae. | 2020 Sep 29 |
1 |
| 12 |
33009372 | The mammalian target of rapamycin (mTOR) kinase mediates haloperidol-induced cataleptic behavior. | 2020 Oct 2 |
1 |
| 13 |
33633735 | Full Activation of Kinase Protein Kinase B by Phosphoinositide-Dependent Protein Kinase-1 and Mammalian Target of Rapamycin Complex 2 Is Required for Early Natural Killer Cell Development and Survival. | 2020 |
1 |
| 14 |
30337688 | mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53. | 2019 Mar |
1 |
| 15 |
30650200 | Targeting mTORC1/2 with OSI-027 inhibits proliferation and migration of keloid keratinocytes. | 2019 Mar |
1 |
| 16 |
30688659 | MAPK4 overexpression promotes tumor progression via noncanonical activation of AKT/mTOR signaling. | 2019 Mar 1 |
1 |
| 17 |
30795552 | Targeting mTOR in Acute Lymphoblastic Leukemia. | 2019 Feb 21 |
1 |
| 18 |
31085701 | Disruption of the Scaffolding Function of mLST8 Selectively Inhibits mTORC2 Assembly and Function and Suppresses mTORC2-Dependent Tumor Growth In Vivo. | 2019 Jul 1 |
1 |
| 19 |
31130364 | Lysosome Positioning Influences mTORC2 and AKT Signaling. | 2019 Jul 11 |
1 |
| 20 |
31624287 | Simulated microgravity inhibits C2C12 myogenesis via phospholipase D2-induced Akt/FOXO1 regulation. | 2019 Oct 17 |
1 |
| 21 |
29077243 | Dual inhibition of the mTORC1 and mTORC2 signaling pathways is a promising therapeutic target for adult T-cell leukemia. | 2018 Jan |
1 |
| 22 |
29883748 | Inflammation-induced mTORC2-Akt-mTORC1 signaling promotes macrophage foam cell formation. | 2018 Aug |
1 |
| 23 |
30201609 | mTORC2 modulates the amplitude and duration of GFAT1 Ser-243 phosphorylation to maintain flux through the hexosamine pathway during starvation. | 2018 Oct 19 |
5 |
| 24 |
30285764 | Reduced menin expression impairs rapamycin effects as evidenced by an increase in mTORC2 signaling and cell migration. | 2018 Oct 1 |
1 |
| 25 |
30571167 | Sin1 (Stress-Activated Protein Kinase-Interacting Protein) Regulates Ischemia-Induced Microthrombosis Through Integrin αIIbβ3-Mediated Outside-In Signaling and Hypoxia Responses in Platelets. | 2018 Dec |
1 |
| 26 |
27777073 | mTORC2 activation is regulated by the urokinase receptor (uPAR) in bladder cancer. | 2017 Jan |
1 |
| 27 |
28123351 | Involvement of Rictor/mTORC2 in cardiomyocyte differentiation of mouse embryonic stem cells in vitro. | 2017 |
1 |
| 28 |
28366631 | The anti-hepatocellular carcinoma cell activity by a novel mTOR kinase inhibitor CZ415. | 2017 Jun 3 |
1 |
| 29 |
28648777 | mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT. | 2017 Jul 6 |
1 |
| 30 |
26979522 | Neuregulin-1β promotes glucose uptake via PI3K/Akt in neonatal rat cardiomyocytes. | 2016 May 1 |
1 |
| 31 |
27015560 | mTOR complex-2 stimulates acetyl-CoA and de novo lipogenesis through ATP citrate lyase in HER2/PIK3CA-hyperactive breast cancer. | 2016 May 3 |
1 |
| 32 |
27016480 | Basal mTORC2 activity and expression of its components display diurnal variation in mouse perivascular adipose tissue. | 2016 Apr 22 |
1 |
| 33 |
27059097 | Mammalian target of rapamycin (mTOR) complex 2 regulates filamin A-dependent focal adhesion dynamics and cell migration. | 2016 Jun |
1 |
| 34 |
27106789 | mTORC2 mediates CXCL12-induced angiogenesis. | 2016 Jul |
1 |
| 35 |
27207509 | Insulin-Dependent Regulation of mTORC2-Akt-FoxO Suppresses TLR4 Signaling in Human Leukocytes: Relevance to Type 2 Diabetes. | 2016 Aug |
1 |
| 36 |
27226562 | Systems-wide Experimental and Modeling Analysis of Insulin Signaling through Forkhead Box Protein O1 (FOXO1) in Human Adipocytes, Normally and in Type 2 Diabetes. | 2016 Jul 22 |
1 |
| 37 |
25673820 | Dual PI3K/mTOR Inhibitors Induce Rapid Overactivation of the MEK/ERK Pathway in Human Pancreatic Cancer Cells through Suppression of mTORC2. | 2015 Apr |
1 |
| 38 |
25796566 | mTOR signaling in aging and neurodegeneration: At the crossroad between metabolism dysfunction and impairment of autophagy. | 2015 Dec |
1 |
| 39 |
25843706 | mTORC2 regulates cardiac response to stress by inhibiting MST1. | 2015 Apr 7 |
1 |
| 40 |
25998128 | Phosphorylation of the Hippo Pathway Component AMOTL2 by the mTORC2 Kinase Promotes YAP Signaling, Resulting in Enhanced Glioblastoma Growth and Invasiveness. | 2015 Aug 7 |
1 |
| 41 |
26025205 | The critical role of Akt in cardiovascular function. | 2015 Nov |
1 |
| 42 |
26109071 | RasGAP Shields Akt from Deactivating Phosphatases in Fibroblast Growth Factor Signaling but Loses This Ability Once Cleaved by Caspase-3. | 2015 Aug 7 |
1 |
| 43 |
26130148 | mTORC2 Balances AKT Activation and eIF2α Serine 51 Phosphorylation to Promote Survival under Stress. | 2015 Oct |
1 |
| 44 |
26201515 | Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin response. | 2015 Oct 1 |
1 |
| 45 |
26459601 | mTORC2 promotes cell survival through c-Myc-dependent up-regulation of E2F1. | 2015 Oct 12 |
1 |
| 46 |
24446434 | Sirt2 deacetylase is a novel AKT binding partner critical for AKT activation by insulin. | 2014 Feb 28 |
1 |
| 47 |
24676635 | Tribbles homolog 3 attenuates mammalian target of rapamycin complex-2 signaling and inflammation in the diabetic kidney. | 2014 Sep |
2 |
| 48 |
24944899 | Rictor/mTORC2 facilitates central regulation of energy and glucose homeostasis. | 2014 Jul |
1 |
| 49 |
25264192 | DNA-PKcs-SIN1 complexation mediates low-dose X-ray irradiation (LDI)-induced Akt activation and osteoblast differentiation. | 2014 Oct 24 |
1 |
| 50 |
25309720 | Posttranslational regulation of Akt in human cancer. | 2014 |
1 |