Chloroquine

mechanistic target of rapamycin kinase ; Homo sapiens







24 Article(s)
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1 35348729 mTOR inhibition and trastuzumab-emtansine (T-DM1) in HER2-positive breast cancer. 2022 Mar 29 1
2 35551547 Survival of HT29 cancer cells is influenced by hepatocyte growth factor receptor inhibition through modulation of self-DNA-triggered TLR9-dependent autophagy response. 2022 1
3 33799790 Tioconazole and Chloroquine Act Synergistically to Combat Doxorubicin-Induced Toxicity via Inactivation of PI3K/AKT/mTOR Signaling Mediated ROS-Dependent Apoptosis and Autophagic Flux Inhibition in MCF-7 Breast Cancer Cells. 2021 Mar 11 2
4 33925206 Therapeutic Approach of KRAS Mutant Tumours by the Combination of Pharmacologic Ascorbate and Chloroquine. 2021 Apr 28 1
5 34229754 Apatinib induces endoplasmic reticulum stress-mediated apoptosis and autophagy and potentiates cell sensitivity to paclitaxel via the IRE-1α-AKT-mTOR pathway in esophageal squamous cell carcinoma. 2021 Jul 6 4
6 34771150 Chloroquine Potentiates the Anticancer Effect of Pterostilbene on Pancreatic Cancer by Inhibiting Autophagy and Downregulating the RAGE/STAT3 Pathway. 2021 Nov 8 2
7 34791996 How Antimalarials and Antineoplastic Drugs can Interact in Combination Therapies: A Perspective on the Role of PPT1 Enzyme. 2021 2
8 31653348 High-throughput screening identified mitoxantrone to induce death of hepatocellular carcinoma cells with autophagy involvement. 2020 Jan 1 2
9 32654071 Inhibition of autophagy by chloroquine enhances the antitumor activity of gemcitabine for gallbladder cancer. 2020 Aug 1
10 30711941 Chloroquine Enhances Rapamycin-induced Apoptosis in MG63 Cells. 2019 Feb 1
11 30897708 CLE-10 from Carpesium abrotanoides L. Suppresses the Growth of Human Breast Cancer Cells (MDA-MB-231) In Vitro by Inducing Apoptosis and Pro-Death Autophagy Via the PI3K/Akt/mTOR Signaling Pathway. 2019 Mar 20 2
12 31059051 The combination of temsirolimus and chloroquine increases radiosensitivity in colorectal cancer cells. 2019 Jul 2
13 29867114 Sorting nexin 10 controls mTOR activation through regulating amino-acid metabolism in colorectal cancer. 2018 Jun 4 1
14 28337019 Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling. 2017 Mar 23 1
15 26212375 Lysosomal pH Plays a Key Role in Regulation of mTOR Activity in Osteoclasts. 2016 Feb 5
16 26619207 Abrogation of Autophagy by Chloroquine Alone or in Combination with mTOR Inhibitors Induces Apoptosis in Neuroendocrine Tumor Cells. 2016 1
17 27779641 AKT/mTOR signaling pathway is involved in salvianolic acid B-induced autophagy and apoptosis in hepatocellular carcinoma cells. 2016 Dec 1
18 26715839 Autophagy facilitates lung adenocarcinoma resistance to cisplatin treatment by activation of AMPK/mTOR signaling pathway. 2015 2
19 25949192 Biphasic activity of chloroquine in human colorectal cancer cells. 2014 Dec 1
20 23111416 Chloroquine overcomes resistance of lung carcinoma cells to the dual PI3K/mTOR inhibitor PI103 by lysosome-mediated apoptosis. 2013 Jan 3
21 23151917 The dual PI3K/mTOR inhibitor NVP-BEZ235 and chloroquine synergize to trigger apoptosis via mitochondrial-lysosomal cross-talk. 2013 Jun 1 1
22 23800949 Characteristics and requirements of basal autophagy in HEK 293 cells. 2013 Sep 2
23 24287900 Blocking autophagic flux enhances matrine-induced apoptosis in human hepatoma cells. 2013 Nov 25 1
24 22142888 Akt and p53 are potential mediators of reduced mammary tumor growth by cloroquine and the mTOR inhibitor RAD001. 2012 Feb 15 2