gemcitabine

mechanistic target of rapamycin kinase ; Homo sapiens







40 Article(s)
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1 34921503 Inhibition of TRIM32 by ibr-7 treatment sensitizes pancreatic cancer cells to gemcitabine via mTOR/p70S6K pathway. 2022 Jan 1
2 35057550 Olive Mill Wastewater Inhibits Growth and Proliferation of Cisplatin- and Gemcitabine-Resistant Bladder Cancer Cells In Vitro by Down-Regulating the Akt/mTOR-Signaling Pathway. 2022 Jan 15 1
3 35218764 Inhibition of FGFR2 enhances chemosensitivity to gemcitabine in cholangiocarcinoma through the AKT/mTOR and EMT signaling pathways. 2022 May 1 2
4 35406478 Gemcitabine Cooperates with Everolimus to Inhibit the Growth of and Sensitize Malignant Meningioma Cells to Apoptosis Induced by Navitoclax, an Inhibitor of Anti-Apoptotic BCL-2 Family Proteins. 2022 Mar 27 1
5 33430324 Water Soluble Iron-Based Coordination Trimers as Synergistic Adjuvants for Pancreatic Cancer. 2021 Jan 7 1
6 33545231 mTOR modulates resistance to gemcitabine in lung cancer in an MTORC2 dependent mechanism. 2021 May 4
7 33760142 [Retracted] Anticancer activity of caffeic acid n‑butyl ester against A431 skin carcinoma cell line occurs via induction of apoptosis and inhibition of the mTOR/PI3K/AKT signaling pathway. 2021 May 2
8 33849427 Everolimus regulates the activity of gemcitabine-resistant pancreatic cancer cells by targeting the Warburg effect via PI3K/AKT/mTOR signaling. 2021 Apr 13 1
9 34119916 Combination of Gemcitabine and Thymosin alpha 1 exhibit a better anti-tumor effect on nasal natural killer/T-cell lymphoma. 2021 Sep 1
10 34416437 The enhancement of Tetrandrine to gemcitabine-resistant PANC-1 cytochemical sensitivity involves the promotion of PI3K/Akt/mTOR-mediated apoptosis and AMPK-regulated autophagy. 2021 Sep 1
11 32654071 Inhibition of autophagy by chloroquine enhances the antitumor activity of gemcitabine for gallbladder cancer. 2020 Aug 2
12 32819590 GDC-0980 (apitolisib) treatment with gemcitabine and/or cisplatin synergistically reduces cholangiocarcinoma cell growth by suppressing the PI3K/Akt/mTOR pathway. 2020 Sep 3 1
13 31354292 Harmine suppresses the proliferation of pancreatic cancer cells and sensitizes pancreatic cancer to gemcitabine treatment. 2019 4
14 31841183 Mechanism of metformin enhancing the sensitivity of human pancreatic cancer cells to gem-citabine by regulating the PI3K/Akt/mTOR signaling pathway. 2019 Dec 4
15 29575133 Gemcitabine induces apoptosis and autophagy via the AMPK/mTOR signaling pathway in pancreatic cancer cells. 2018 Sep 1
16 30416856 Monepantel considerably enhances the therapeutic potentials of PEGylated liposomal doxorubicin and gemcitabine in ovarian cancer: in vitro and in vivo studies. 2018 1
17 30419950 LAT2 regulates glutamine-dependent mTOR activation to promote glycolysis and chemoresistance in pancreatic cancer. 2018 Nov 12 1
18 30662800 Antitumor activity of the novel HDAC inhibitor CUDC-101 combined with gemcitabine in pancreatic cancer. 2018 1
19 28165150 Everolimus Inhibits Growth of Gemcitabine-Resistant Pancreatic Cancer Cells via Induction of Caspase-Dependent Apoptosis and G2 /M Arrest. 2017 Sep 3
20 29018223 Mechanistic Evaluation and Translational Signature of Gemcitabine-induced Chemoresistance by Quantitative Phosphoproteomics Analysis with iTRAQ Labeling Mass Spectrometry. 2017 Oct 10 1
21 27235118 mTOR inhibitors in urinary bladder cancer. 2016 Sep 2
22 25344906 Thymoquinone Pretreatment Overcomes the Insensitivity and Potentiates the Antitumor Effect of Gemcitabine Through Abrogation of Notch1, PI3K/Akt/mTOR Regulated Signaling Pathways in Pancreatic Cancer. 2015 Apr 1
23 25586480 Sirolimus plus gemcitabine: a new therapeutic combination for resistant sarcomas? 2015 Mar 1
24 26085897 Sequential treatments in hereditary leiomyomatosis and renal cell carcinoma (HLRCC): Case report and review of the literature. 2015 Mar-Apr 2
25 26500758 Cytotoxic and targeted therapy for treatment of pseudomyogenic hemangioendothelioma. 2015 1
26 24654937 Identification of new mechanisms of cellular response to chemotherapy by tracking changes in post-translational modifications by ubiquitin and ubiquitin-like proteins. 2014 May 2 1
27 24804820 The cytoprotective role of gemcitabine-induced autophagy associated with apoptosis inhibition in triple-negative MDA-MB-231 breast cancer cells. 2014 Jul 1
28 24902539 Phenoxodiol enhances the antitumor activity of gemcitabine in gallbladder cancer through suppressing Akt/mTOR pathway. 2014 Nov 1
29 24959297 Successful mammalian target of rapamycin inhibitor maintenance therapy following induction chemotherapy with gemcitabine and doxorubicin for metastatic sarcomatoid renal cell carcinoma. 2014 Jul 1
30 24966685 Gemcitabine resistance in breast cancer cells regulated by PI3K/AKT-mediated cellular proliferation exerts negative feedback via the MEK/MAPK and mTOR pathways. 2014 1
31 25003665 Phase I study and preclinical efficacy evaluation of the mTOR inhibitor sirolimus plus gemcitabine in patients with advanced solid tumours. 2014 Aug 26 1
32 22488590 Inhibition of constitutively activated phosphoinositide 3-kinase/AKT pathway enhances antitumor activity of chemotherapeutic agents in breast cancer susceptibility gene 1-defective breast cancer cells. 2013 Sep 1
33 23579097 BLU enhances the effects of anti-angiogenic activity in combination with gemcitabine-based chemotherapeutic agents. 2013 Jul 1
34 22406590 First-line treatment of metastatic pancreatic cancer. 2012 Mar 10 1
35 22532602 CDK-4 inhibitor P276 sensitizes pancreatic cancer cells to gemcitabine-induced apoptosis. 2012 Jul 1
36 22726648 Akt/mTOR signaling pathway is crucial for gemcitabine resistance induced by Annexin II in pancreatic cancer cells. 2012 Dec 4
37 22903553 sMEK1 enhances gemcitabine anti-cancer activity through inhibition of phosphorylation of Akt/mTOR. 2012 Oct 2
38 20460539 MicroRNA-21 in pancreatic cancer: correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity. 2010 Jun 1 1
39 19047305 Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer. 2009 Jan 10 2
40 18251175 Rapamycin enhances the anti-tumor effect of gemcitabine in pancreatic cancer cells. 2007 Oct-Nov 1