Bortezomib

mechanistic target of rapamycin kinase ; Homo sapiens







23 Article(s)
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1 33289516 Bortezomib limits renal allograft interstitial fibrosis by inhibiting NF-κB/TNF-α/Akt/mTOR/P70S6K/Smurf2 pathway via IκBα protein stabilization. 2021 Jan 15 3
2 33564319 In Vitro Investigation of the Cytotoxic Activity of Emodin 35 Derivative on Multiple Myeloma Cell Lines. 2021 1
3 33938943 G9a/GLP targeting in MM promotes autophagy-associated apoptosis and boosts proteasome inhibitor-mediated cell death. 2021 May 11 1
4 32126150 Inhibition of PLK4 might enhance the anti-tumour effect of bortezomib on glioblastoma via PTEN/PI3K/AKT/mTOR signalling pathway. 2020 Apr 1
5 33191863 Blockade of PLD1 potentiates the antitumor effects of bortezomib in multiple myeloma cells by inhibiting the mTOR/NF-κB signal pathway. 2020 Dec 2
6 29997148 Everolimus shows synergistic antimyeloma effects with bortezomib via the AKT/mTOR pathway. 2019 Jan 1
7 31140729 Bortezomib attenuates renal interstitial fibrosis in kidney transplantation via regulating the EMT induced by TNF-α-Smurf1-Akt-mTOR-P70S6K pathway. 2019 Aug 1
8 28696812 A phase I trial of bortezomib in combination with everolimus for treatment of relapsed/refractory non-Hodgkin lymphoma. 2018 Mar 1
9 28899456 ClC5 Decreases the Sensitivity of Multiple Myeloma Cells to Bortezomib via Promoting Prosurvival Autophagy. 2018 Apr 10 2
10 29057477 The MIP-1α autocrine loop contributes to decreased sensitivity to anticancer drugs. 2018 May 2
11 29482577 Inhibition of thioredoxin activates mitophagy and overcomes adaptive bortezomib resistance in multiple myeloma. 2018 Feb 27 1
12 29755672 Inhibition of mTOR complex 2 restrains tumor angiogenesis in multiple myeloma. 2018 Apr 17 1
13 29996117 Blocking Mammalian Target of Rapamycin (mTOR) Alleviates Neuropathic Pain Induced by Chemotherapeutic Bortezomib. 2018 5
14 28549771 Calcineurin and mTOR Inhibitor-Free Post-Transplantation Cyclophosphamide and Bortezomib Combination for Graft-versus-Host Disease Prevention after Peripheral Blood Allogeneic Hematopoietic Stem Cell Transplantation: A Phase I/II Study. 2017 Oct 1
15 25530422 The proteasome inhibitor Bortezomib (Velcade) as potential inhibitor of estrogen receptor-positive breast cancer. 2015 Aug 1 2
16 26194835 Effect of bortezomib on migration and invasion in cervical carcinoma HeLa cell. 2015 Jun 2
17 23916134 Nelfinavir and bortezomib inhibit mTOR activity via ATF4-mediated sestrin-2 regulation. 2013 Dec 1
18 26824026 Cap dependent translation contributes to resistance of myeloma cells to bortezomib. 2013 1
19 21909688 Bortezomib represses HIF-1α protein expression and nuclear accumulation by inhibiting both PI3K/Akt/TOR and MAPK pathways in prostate cancer cells. 2012 Jan 1
20 22313636 Bortezomib induces apoptosis and growth suppression in human medulloblastoma cells, associated with inhibition of AKT and NF-ĸB signaling, and synergizes with an ERK inhibitor. 2012 Apr 1
21 22339676 Knockdown of c-Met enhances sensitivity to bortezomib in human multiple myeloma U266 cells via inhibiting Akt/mTOR activity. 2012 Mar 3
22 22560334 The dual PI3K and mTOR inhibitor NVP-BEZ235 exhibits anti-proliferative activity and overcomes bortezomib resistance in mantle cell lymphoma cells. 2012 Jul 2
23 20100206 Inhibition of mTORC1 activity by REDD1 induction in myeloma cells resistant to bortezomib cytotoxicity. 2010 Apr 1