Sunitinib

mechanistic target of rapamycin kinase ; Homo sapiens







42 Article(s)
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1 31331862 Metastatic Renal Cell Carcinoma Rapidly Progressive to Sunitinib: What to Do Next? 2021 Apr 1
2 33995090 Sodium-Glucose CoTransporter-2 Inhibitor Empagliflozin Ameliorates Sunitinib-Induced Cardiac Dysfunction via Regulation of AMPK-mTOR Signaling Pathway-Mediated Autophagy. 2021 2
3 32232883 Potential new therapy of Rapalink-1, a new generation mammalian target of rapamycin inhibitor, against sunitinib-resistant renal cell carcinoma. 2020 May 1
4 31031856 Dual-Inhibition of mTOR and Bcl-2 Enhances the Anti-tumor Effect of Everolimus against Renal Cell Carcinoma In Vitro and In Vivo. 2019 2
5 30369518 Interleukin-6 induces drug resistance in renal cell carcinoma. 2018 Dec 8 1
6 30651932 Second-line treatment after sunitinib therapy in patients with renal cell carcinoma: a comparison of axitinib and mammalian target of rapamycin inhibitors. 2018 Dec 11 1
7 27395374 Expression and prognostic significance of VEGF and mTOR pathway proteins in metastatic renal cell carcinoma patients: a prognostic immunohistochemical profile for kidney cancer patients. 2017 Mar 1
8 27893461 Dual modulation of MCL-1 and mTOR determines the response to sunitinib. 2017 Jan 3 1
9 27958294 Targeted therapy: Sunitinib modulates MCL-1 and mTOR signalling. 2017 Feb 1
10 28413468 Antitumor effect of sunitinib in human prostate cancer cells functions via autophagy. 2017 Apr 1
11 28672196 Contrast-Enhanced CT Density Predicts Response to Sunitinib Therapy in Metastatic Renal Cell Carcinoma Patients. 2017 Aug 1
12 28903416 Overriding TKI resistance of renal cell carcinoma by combination therapy with IL-6 receptor blockade. 2017 Aug 15 1
13 28993730 Molecular Guided Therapy Provides Sustained Clinical Response in Refractory Choroid Plexus Carcinoma. 2017 1
14 29262588 Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) regulates the cell metabolism of pancreatic neuroendocrine tumors (pNET) and de-sensitizes pNET to mTOR inhibitors. 2017 Nov 28 1
15 27031198 [Systemic therapy of metastatic renal cell carcinoma]. 2016 Apr 1
16 27103123 Phase I study of safety and tolerability of sunitinib in combination with sirolimus in patients with refractory solid malignancies and determination of VEGF (VEGF-A) and soluble VEGF-R2 (sVEGFR2) in plasma. 2016 Jun 1
17 27538132 [Sunitinib induces autophagy via suppressing Akt/mTOR pathway in renal cell carcinoma]. 2016 Feb 18 5
18 27990160 The Roles of PI3K/AKT/mTOR and MAPK/ERK Signaling Pathways in Human Pheochromocytomas. 2016 1
19 29263493 [Sunitinib induces autophagy via suppressing Akt/mTOR pathway in renal cell carcinoma]. 2016 Aug 18 5
20 25444514 Molecular analysis of sunitinib resistant renal cell carcinoma cells after sequential treatment with RAD001 (everolimus) or sorafenib. 2015 Feb 1
21 25862847 Targeting mTOR and AREG with everolimus, sunitinib and sorafenib in HPV-positive and -negative SCC. 2015 Apr 1
22 25963382 Targeted therapies for treatment of renal cell carcinoma: recent advances and future perspectives. 2015 Aug 1
23 24018642 Systematic combination screening reveals synergism between rapamycin and sunitinib against human lung cancer. 2014 Jan 1 1
24 24800947 Sunitinib re-challenge in advanced renal-cell carcinoma. 2014 Sep 9 1
25 25193011 Renal cell carcinoma with intramyocardial metastases. 2014 Sep 6 1
26 25764782 [The newest perspectives on diagnostic methods and treatment of insulinoma]. 2014 1
27 25841679 Emerging therapies for pancreas neuroendocrine cancers. 2013 Sep 1
28 21445973 Long-term exposure of gastrointestinal stromal tumor cells to sunitinib induces epigenetic silencing of the PTEN gene. 2012 Feb 15 2
29 21735145 Maximising the duration of disease control in metastatic renal cell carcinoma with targeted agents: an expert agreement. 2012 Sep 2
30 22338018 New strategies for advanced neuroendocrine tumors in the era of targeted therapy. 2012 Apr 1 1
31 22532600 Modulation of Akt/mTOR signaling overcomes sunitinib resistance in renal and prostate cancer cells. 2012 Jul 2
32 21625184 Efficacy of sunitinib re-exposure after failure of an mTOR inhibitor in patients with metastatic RCC. 2011 1
33 21672194 Evolving diagnostic and treatment strategies for pancreatic neuroendocrine tumors. 2011 Jun 14 1
34 20053726 Sunitinib induces apoptosis and growth arrest of medulloblastoma tumor cells by inhibiting STAT3 and AKT signaling pathways. 2010 Jan 1
35 20471160 mTOR inhibition by everolimus counteracts VEGF induction by sunitinib and improves anti-tumor activity against gastric cancer in vivo. 2010 Oct 28 4
36 20625300 Novel targeted therapy for advanced renal carcinoma: trials in progress. 2010 Sep 1
37 21067536 Antiangiogenic therapy for breast cancer. 2010 1
38 19412427 In vivo antitumor and antimetastatic activity of sunitinib in preclinical neuroblastoma mouse model. 2009 May 1
39 19467916 FLT3 inhibition and mechanisms of drug resistance in mutant FLT3-positive AML. 2009 Jun 2
40 17935273 Sunitinib, sorafenib and mTOR inhibitors in renal cancer. 2007 Sep 1
41 16916320 Effect of SU11248 on gastrointestinal stromal tumor-T1 cells: enhancement of growth inhibition via inhibition of 3-kinase/Akt/mammalian target of rapamycin signaling. 2006 Sep 2
42 16995874 ZD6474 induces growth arrest and apoptosis of GIST-T1 cells, which is enhanced by concomitant use of sunitinib. 2006 Dec 1