Melatonin

mechanistic target of rapamycin kinase ; Homo sapiens







35 Article(s)
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1 35328408 Melatonin Signaling Pathways Implicated in Metabolic Processes in Human Granulosa Cells (KGN). 2022 Mar 10 1
2 34580235 Melatonin inhibits proliferation, migration, and invasion by inducing ROS-mediated apoptosis via suppression of the PI3K/Akt/mTOR signaling pathway in gallbladder cancer cells. 2021 Sep 27 4
3 31605630 Melatonin attenuates epidermal growth factor-induced cathepsin S expression in ARPE-19 cells: Implications for proliferative vitreoretinopathy. 2020 Jan 2
4 32014443 Melatonin attenuates vascular calcification by activating autophagy via an AMPK/mTOR/ULK1 signaling pathway. 2020 Apr 1 6
5 32096202 Melatonin reduces OGD/R-induced neuron injury by regulating redox/inflammation/apoptosis signaling. 2020 Feb 3
6 32241504 Melatonin regulates the ovarian function and enhances follicle growth in aging laying hens via activating the mammalian target of rapamycin pathway. 2020 Apr 1
7 32792862 Jagged2 progressively increased expression from Stage I to III of Bladder Cancer and Melatonin-mediated downregulation of Notch/Jagged2 suppresses the Bladder Tumorigenesis via inhibiting PI3K/AKT/mTOR/MMPs signaling. 2020 3
8 33142533 Melatonin regulates chicken granulosa cell proliferation and apoptosis by activating the mTOR signaling pathway via its receptors. 2020 Nov 1
9 33571963 Nanomolar melatonin influences insulin synthesis and secretion in rat insulinoma INS-1E cells. 2020 Oct 2
10 30661353 Melatonin Inhibits in Vitro Smooth Muscle Cell Inflammation and Proliferation and Atherosclerosis in Apolipoprotein E-Deficient Mice. 2019 Feb 20 2
11 30843672 Melatonin protects against streptozotocin-induced diabetic cardiomyopathy through the mammalian target of rapamycin (mTOR) signaling pathway. 2019 Sep 2
12 30862067 Aging, Melatonin, and the Pro- and Anti-Inflammatory Networks. 2019 Mar 11 1
13 31247931 Melatonin Prevents Oxidative Stress-Induced Mitochondrial Dysfunction and Apoptosis in High Glucose-Treated Schwann Cells via Upregulation of Bcl2, NF-κB, mTOR, Wnt Signalling Pathways. 2019 Jun 26 2
14 31803045 Melatonin and Rapamycin Attenuate Isoflurane-Induced Cognitive Impairment Through Inhibition of Neuroinflammation by Suppressing the mTOR Signaling in the Hippocampus of Aged Mice. 2019 2
15 31836786 Interaction of melatonin and Bmal1 in the regulation of PI3K/AKT pathway components and cellular survival. 2019 Dec 13 1
16 28655071 Melatonin Rescues Mesenchymal Stem Cells from Senescence Induced by the Uremic Toxin p-Cresol via Inhibiting mTOR-Dependent Autophagy. 2018 Jul 1 1
17 29247557 Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation. 2018 Apr 2
18 29641494 Maternal Melatonin Therapy Attenuated Maternal High-Fructose Combined with Post-Weaning High-Salt Diets-Induced Hypertension in Adult Male Rat Offspring. 2018 Apr 11 1
19 29895782 Effects of Melatonin and Its Underlying Mechanism on Ethanol-Stimulated Senescence and Osteoclastic Differentiation in Human Periodontal Ligament Cells and Cementoblasts. 2018 Jun 12 2
20 29975938 Melatonin Attenuates Myocardial Ischemia/Reperfusion Injury by Inhibiting Autophagy Via an AMPK/mTOR Signaling Pathway. 2018 4
21 30242884 Melatonin and inflammation-Story of a double-edged blade. 2018 Nov 2
22 30261648 Combined Fluid Shear Stress and Melatonin Enhances the ERK/Akt/mTOR Signal in Cilia-Less MC3T3-E1 Preosteoblast Cells. 2018 Sep 26 2
23 27117839 Melatonin attenuates traumatic brain injury-induced inflammation: a possible role for mitophagy. 2016 Sep 1
24 24799992 Melatonin attenuates cisplatin-induced HepG2 cell death via the regulation of mTOR and ERCC1 expressions. 2014 Apr 27 4
25 24995391 Melatonin reduced microglial activation and alleviated neuroinflammation induced neuron degeneration in experimental traumatic brain injury: Possible involvement of mTOR pathway. 2014 Oct 3
26 25247581 Melatonin regulates aging and neurodegeneration through energy metabolism, epigenetics, autophagy and circadian rhythm pathways. 2014 Sep 22 2
27 23363291 Melatonin induces autophagy via an mTOR-dependent pathway and enhances clearance of mutant-TGFBIp. 2013 May 3
28 23397978 Fluid shear stress and melatonin in combination activate anabolic proteins in MC3T3-E1 osteoblast cells. 2013 May 2
29 22222116 Involvement of melatonin in autophagy-mediated mouse hepatoma H22 cell survival. 2012 Feb 1
30 22582971 Melatonin-induced autophagy is associated with degradation of MyoD protein in C2C12 myoblast cells. 2012 Oct 2
31 22686283 Melatonin prevents hemorrhagic shock-induced liver injury in rats through an Akt-dependent HO-1 pathway. 2012 Nov 2
32 20577026 Long-term melatonin administration enhances the antioxidant potential of human plasma maintained after discontinuation of the treatment. 2010 Jun 1
33 19054297 Melatonin attenuates methamphetamine-induced deactivation of the mammalian target of rapamycin signaling to induce autophagy in SK-N-SH cells. 2009 Mar 2
34 18410586 Melatonin represses oxidative stress-induced activation of the MAP kinase and mTOR signaling pathways in H4IIE hepatoma cells through inhibition of Ras. 2008 May 2
35 18721861 Melatonin prevents ischemic brain injury through activation of the mTOR/p70S6 kinase signaling pathway. 2008 Oct 17 5