| 1 |
35093670 | Recent strategies targeting Embryonic Ectoderm Development (EED) for cancer therapy: Allosteric inhibitors, PPI inhibitors, and PROTACs. | 2022 Mar 5 |
1 |
| 2 |
35169119 | Induction of senescence-associated secretory phenotype underlies the therapeutic efficacy of PRC2 inhibition in cancer. | 2022 Feb 15 |
1 |
| 3 |
33232890 | Structural basis for PRC2 engagement with chromatin. | 2021 Apr |
1 |
| 4 |
32394628 | Identification of catalytic and non-catalytic activity inhibitors against PRC2-EZH2 complex through multiple high-throughput screening campaigns. | 2020 Oct |
1 |
| 5 |
32666581 | H3K27me3 expression and methylation status in histological variants of malignant peripheral nerve sheath tumours. | 2020 Oct |
1 |
| 6 |
31024026 | Discovery of selective activators of PRC2 mutant EED-I363M. | 2019 Apr 25 |
1 |
| 7 |
31024250 | EZH2 Is Essential for Fate Determination in the Mammalian Isthmic Area. | 2019 |
1 |
| 8 |
31107719 | Beyond "Triton": Malignant Peripheral Nerve Sheath Tumors With Complete Heterologous Rhabdomyoblastic Differentiation Mimicking Spindle Cell Rhabdomyosarcoma. | 2019 Oct |
1 |
| 9 |
31204298 | Polycomb Protein EED Regulates Neuronal Differentiation through Targeting SOX11 in Hippocampal Dentate Gyrus. | 2019 Jul 9 |
2 |
| 10 |
31492675 | Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia. | 2019 Oct 17 |
1 |
| 11 |
31527584 | PICOT binding to chromatin-associated EED negatively regulates cyclin D2 expression by increasing H3K27me3 at the CCND2 gene promoter. | 2019 Sep 17 |
1 |
| 12 |
31550663 | A drug repurposing screening reveals a novel epigenetic activity of hydroxychloroquine. | 2019 Dec 1 |
1 |
| 13 |
29482987 | Immunohistochemical evaluation of H3K27 trimethylation in malignant peripheral nerve sheath tumors. | 2018 Mar |
1 |
| 14 |
29606589 | The H3K36me2 Methyltransferase Nsd1 Demarcates PRC2-Mediated H3K27me2 and H3K27me3 Domains in Embryonic Stem Cells. | 2018 Apr 19 |
1 |
| 15 |
30005706 | Loss of maternal EED results in postnatal overgrowth. | 2018 Jul 13 |
1 |
| 16 |
27845897 | The JAZF1-SUZ12 fusion protein disrupts PRC2 complexes and impairs chromatin repression during human endometrial stromal tumorogenesis. | 2017 Jan 17 |
1 |
| 17 |
28092155 | Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy. | 2017 Mar 23 |
1 |
| 18 |
28135235 | An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED. | 2017 Apr |
1 |
| 19 |
28165227 | Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2. | 2017 Mar 13 |
1 |
| 20 |
28229514 | Mutations in genes encoding polycomb repressive complex 2 subunits cause Weaver syndrome. | 2017 Jun |
2 |
| 21 |
28508686 | Malignant Peripheral Nerve Sheath Tumor of the Femur: A Rare Diagnosis Supported by Complete Immunohistochemical Loss of H3K27me3. | 2017 Oct |
1 |
| 22 |
28898989 | Role of Histone H3K27 Trimethylation Loss as a Marker for Malignant Peripheral Nerve Sheath Tumor in Fine-Needle Aspiration and Small Biopsy Specimens. | 2017 Aug 1 |
1 |
| 23 |
26645727 | Loss of H3K27me3 Expression Is a Highly Sensitive Marker for Sporadic and Radiation-induced MPNST. | 2016 Apr |
1 |
| 24 |
27550047 | Long Non-coding RNA HOTAIR Expression in Diffuse Large B-Cell Lymphoma: In Relation to Polycomb Repressive Complex Pathway Proteins and H3K27 Trimethylation. | 2016 Sep |
1 |
| 25 |
25134795 | Polycomb protein EED is required for silencing of pluripotency genes upon ESC differentiation. | 2015 Feb |
2 |
| 26 |
26420484 | Histone Deacetylase 3 Coordinates Deacetylase-independent Epigenetic Silencing of Transforming Growth Factor-β1 (TGF-β1) to Orchestrate Second Heart Field Development. | 2015 Nov 6 |
1 |
| 27 |
26497635 | PRC2 mediated H3K27 methylations in cellular identity and cancer. | 2015 Dec |
1 |
| 28 |
25264103 | EED regulates epithelial-mesenchymal transition of cancer cells induced by TGF-β. | 2014 Oct 10 |
1 |
| 29 |
25369470 | Astemizole arrests the proliferation of cancer cells by disrupting the EZH2-EED interaction of polycomb repressive complex 2. | 2014 Nov 26 |
1 |
| 30 |
23671187 | EED and KDM6B coordinate the first mammalian cell lineage commitment to ensure embryo implantation. | 2013 Jul |
1 |
| 31 |
24077602 | Scaffold attachment factor B1: an intrinsic inhibitor of androgen receptor downregulated in prostate cancer. | 2013 Nov |
1 |
| 32 |
22871331 | The polycomb group protein EED varies in its ability to access the nucleus in porcine oocytes and cleavage stage embryos. | 2012 Aug |
1 |
| 33 |
21367748 | Aberrations of EZH2 in cancer. | 2011 May 1 |
1 |
| 34 |
20974918 | Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). | 2010 Nov 9 |
1 |
| 35 |
17107999 | Juxtaposed Polycomb complexes co-regulate vertebral identity. | 2006 Dec |
1 |
| 36 |
15986205 | Developmental regulation of Suz 12 localization. | 2005 Aug |
1 |
| 37 |
15231737 | Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27. | 2004 Jul 1 |
1 |