Cytarabine

BCL2 apoptosis regulator ; Homo sapiens







63 Article(s)
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1 34966123 Venetoclax combination therapy in acute myeloid leukemia and myelodysplastic syndromes. 2022 Mar 1 1
2 33919958 Venetoclax-Based Regimens for Relapsed/Refractory Acute Myeloid Leukemia in a Real-Life Setting: A Retrospective Single-Center Experience. 2021 Apr 14 1
3 34059487 A Real-life Turkish Experience of Venetoclax Treatment in High-risk Myelodysplastic Syndrome and Acute Myeloid Leukemia. 2021 Aug 2
4 34251414 Phase 3 randomized trial of chemotherapy with or without oblimersen in older AML patients: CALGB 10201 (Alliance). 2021 Jul 13 1
5 32171069 Venetoclax in combination with cytarabine with or without idarubicin in children with relapsed or refractory acute myeloid leukaemia: a phase 1, dose-escalation study. 2020 Apr 1
6 32687450 Chemotherapy and Venetoclax in Elderly Acute Myeloid Leukemia Trial (CAVEAT): A Phase Ib Dose-Escalation Study of Venetoclax Combined With Modified Intensive Chemotherapy. 2020 Oct 20 2
7 30535449 Cyr61 decreases Cytarabine chemosensitivity in acute lymphoblastic leukemia cells via NF-κB pathway activation. 2019 Feb 1
8 30813354 Emerging Therapies for Acute Myelogenus Leukemia Patients Targeting Apoptosis and Mitochondrial Metabolism. 2019 Feb 22 2
9 31881855 In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells. 2019 Dec 27 1
10 29477371 Venetoclax: A new wave in hematooncology. 2018 May 1
11 29872325 miR-134 increases the antitumor effects of cytarabine by targeting Mnks in acute myeloid leukemia cells. 2018 1
12 30361682 Repression of Mcl-1 expression by the CDC7/CDK9 inhibitor PHA-767491 overcomes bone marrow stroma-mediated drug resistance in AML. 2018 Oct 25 1
13 27922189 Optimal AraC-Cytotoxicity to AML Cells Requires ERK5 Activity. 2017 Jun 2
14 28721010 Antiglioma effects of cytarabine on leptomeningeal metastasis of high-grade glioma by targeting the PI3K/Akt/mTOR pathway. 2017 1
15 28810561 Cytotoxic T lymphocytes promote cytarabine-induced acute myeloid leukemia cell apoptosis via inhibiting Bcl-2 expression. 2017 Aug 3
16 26028971 Development and molecular characterization of polymeric micro-nanofibrous scaffold of a defined 3-D niche for in vitro chemosensitivity analysis against acute myeloid leukemia cells. 2015 3
17 26375587 Mitochondrial Profiling of Acute Myeloid Leukemia in the Assessment of Response to Apoptosis Modulating Drugs. 2015 1
18 24342948 BCL2-specific inhibitor ABT-199 synergizes strongly with cytarabine against the early immature LOUCY cell line but not more-differentiated T-ALL cell lines. 2014 May 1
19 23320492 Combination of guanine arabinoside and Bcl-2 inhibitor YC137 overcomes the cytarabine resistance in HL-60 leukemia cell line. 2013 Apr 3
20 24370051 [Effect of salidroside on apoptosis of bone marrow mesenchymal stem cells induced by ara-C]. 2013 Dec 1
21 22209977 miR-181a sensitizes resistant leukaemia HL-60/Ara-C cells to Ara-C by inducing apoptosis. 2012 Apr 1
22 21212792 The cyclin-dependent kinase inhibitor SNS-032 has single agent activity in AML cells and is highly synergistic with cytarabine. 2011 Mar 3
23 19204830 Small hairpin RNA targeting at Bcl-2 increases cytarabine-induced apoptosis in Raji cells. 2009 Feb 7
24 17490525 [Effect of nimodipine on mechanisms of HL-60 cell apoptosis induced by cytarabine]. 2007 Feb 2
25 16112192 Human stem cell factor-antibody [anti-SCF] enhances chemotherapy cytotoxicity in human CD34+ resistant myeloid leukaemia cells. 2006 Mar 2
26 16219908 Flavopiridol and histone deacetylase inhibitors promote mitochondrial injury and cell death in human leukemia cells that overexpress Bcl-2. 2006 Jan 4
27 16129037 [Study on mechanism of apoptosis of HL-60 cells induced by cytarabine]. 2005 Aug 2
28 15631654 [A novel bcl-2 antisense oligodeoxynucleotide F951 increases sensitivity of HL-60 cells to Ara-C]. 2004 Dec 1
29 12488556 Bryostatin 1 and UCN-01 potentiate 1-beta-D-arabinofuranosylcytosine-induced apoptosis in human myeloid leukemia cells through disparate mechanisms. 2003 Jan 1
30 12667288 [Design of antisense oligodeoxynucleotide targeting at bcl-2 mRNA and observation on its effect on the sensitivity of leukemia cells to arabinosyl cytosine]. 2003 Feb 6
31 12853972 Mechanism of cytosine arabinoside-mediated apoptosis: role of Rel A (p65) dephosphorylation. 2003 Jul 10 1
32 12931228 HA14-1 selectively induces apoptosis in Bcl-2-overexpressing leukemia/lymphoma cells, and enhances cytarabine-induced cell death. 2003 Nov 1
33 12170773 Loss of the Bcl-2 phosphorylation loop domain is required to protect human myeloid leukemia cells from flavopiridol-mediated mitochondrial damage and apoptosis. 2002 Mar-Apr 1
34 12520735 [Bcl-2 antisense oligodeoxynucleotide enhances araninosyl cytosine-induced apoptosis of primary leukemia cells]. 2002 Dec 4
35 12533044 Chemotherapy induces bcl-2 cleavage in lymphoid leukemic cell lines. 2002 Nov 2
36 11299723 Development of a double-drug-resistant human leukemia model to cytosine arabinoside and L-asparaginase: evaluation of cross-resistance to other treatment modalities. 2001 Jan-Feb 1
37 11351258 Resistance of human leukemic cell lines to 1-beta-D-arabinofuranosylcytosine: characterization of an experimental model. 2001 Jun 1
38 11848518 Ajoene, a garlic-derived natural compound, enhances chemotherapy-induced apoptosis in human myeloid leukaemia CD34-positive resistant cells. 2001 Sep-Oct 1
39 10769646 Cytosine arabinoside (ara-C) resistance confers cross-resistance or collateral sensitivity to other classes of anti-leukemic drugs. 2000 Jan-Feb 6
40 10845930 Liposomal Bcl-2 antisense oligonucleotides enhance proliferation, sensitize acute myeloid leukemia to cytosine-arabinoside, and induce apoptosis independent of other antiapoptotic proteins. 2000 Jun 15 4
41 10997587 Evidence of a functional role for the cyclin-dependent kinase inhibitor p21CIP1 in leukemic cell (U937) differentiation induced by low concentrations of 1-beta-D-arabinofuranosylcytosine. 2000 Aug 1
42 11020446 Potentiation of 1-beta-D-arabinofuranosylcytosine-mediated mitochondrial damage and apoptosis in human leukemia cells (U937) overexpressing bcl-2 by the kinase inhibitor 7-hydroxystaurosporine (UCN-01). 2000 Nov 15 3
43 10023011 Bcl-2 protein in human myeloid leukaemia cells and its down-regulation during chemotherapy-induced apoptosis. 1999 Mar-Apr 3
44 10456672 Effect of all-trans retinoic acid on chemotherapy induced apoptosis and down-regulation of Bcl-2 in human myeloid leukaemia CD34 positive cells. 1999 Aug 3
45 10500808 BCL-2 expression in childhood leukemia versus spontaneous apoptosis, drug induced apoptosis, and in vitro drug resistance. 1999 1
46 10500809 Comparison of BCL-2 and BAX protein expression with in vitro sensitivity to ARA-C and 6TG in AML. 1999 2
47 10557066 Expression of Bcl-2-related genes in normal and AML progenitors: changes induced by chemotherapy and retinoic acid. 1999 Nov 3
48 9338077 Ara-C: cellular and molecular pharmacology. 1998 1
49 9699642 "Loop" domain is necessary for taxol-induced mobility shift and phosphorylation of Bcl-2 as well as for inhibiting taxol-induced cytosolic accumulation of cytochrome c and apoptosis. 1998 Aug 1 4
50 9840183 An oxidative stress-mediated death pathway in irradiated human leukemia cells mapped using multilaser flow cytometry. 1998 Dec 1